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alpha-2-macroglobulin

Summary

Gene Symbol

Organism

Homo sapiens (human)

External Links

NCBI Gene

PubChem

Alliance of Genome Resources

HGNC:7

Annotation

Keyword

3D-structure
Bait region
Direct protein sequencing
Disulfide bond
Glycoprotein
Isopeptide bond
Reference proteome
Secreted
Serine protease inhibitor
Signal
Thioester bond

Proteins

Displaying 1 entry
UniProt	Protein Name
P01023	C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
response to prostaglandin E	IEA
negative regulation of peptidase activity	IEA
acute inflammatory response to antigenic stimulus	IEA
response to nutrient	IEA
response to glucocorticoid	IEA

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

inflammatory response to antigenic stimulus [inference]

acute inflammatory response to antigenic stimulus

cellular process [inference]

cellular developmental process [inference]

cell differentiation [inference]

stem cell differentiation

reproductive process [inference]

ovulation cycle process [inference]

luteinization

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

embryonic organ development [inference]

embryonic liver development

cellular developmental process [inference]

cell differentiation [inference]

stem cell differentiation

rhythmic process [inference]

ovulation cycle process [inference]

luteinization

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response [inference]

inflammatory response to antigenic stimulus [inference]

acute inflammatory response to antigenic stimulus

acute inflammatory response [inference]

immune response [inference]

inflammatory response to antigenic stimulus [inference]

acute inflammatory response to antigenic stimulus

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to nutrient

response to endogenous stimulus [inference]

response to hormone [inference]

response to prostaglandin [inference]

response to prostaglandin E

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to chemical [inference]

response to nutrient

response to organic substance [inference]

response to hormone [inference]

response to prostaglandin [inference]

response to prostaglandin E

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to carbon dioxide

response to organic cyclic compound [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to lipid [inference]

response to prostaglandin [inference]

response to prostaglandin E

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to alcohol [inference]

response to prostaglandin E

response to ketone [inference]

response to prostaglandin E

response to oxygen-containing compound [inference]

response to carbon dioxide

response to alcohol [inference]

response to prostaglandin E

response to ketone [inference]

response to prostaglandin E

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of immune effector process [inference]

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

regulation of immune effector process [inference]

negative regulation of immune effector process [inference]

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

regulation of complement activation [inference]

regulation of complement activation, lectin pathway [inference]

negative regulation of complement activation, lectin pathway

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

regulation of immune response [inference]

regulation of humoral immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

regulation of complement activation [inference]

regulation of complement activation, lectin pathway [inference]

negative regulation of complement activation, lectin pathway

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

regulation of innate immune response [inference]

regulation of complement activation, lectin pathway [inference]

negative regulation of complement activation, lectin pathway

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of immune effector process [inference]

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of response to stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

negative regulation of defense response [inference]

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

negative regulation of response to external stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

regulation of innate immune response [inference]

regulation of complement activation, lectin pathway [inference]

negative regulation of complement activation, lectin pathway

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

regulation of innate immune response [inference]

regulation of complement activation, lectin pathway [inference]

negative regulation of complement activation, lectin pathway

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

negative regulation of response to stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

negative regulation of defense response [inference]

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

negative regulation of response to external stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

regulation of immune response [inference]

regulation of humoral immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

regulation of complement activation [inference]

regulation of complement activation, lectin pathway [inference]

negative regulation of complement activation, lectin pathway

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

regulation of innate immune response [inference]

regulation of complement activation, lectin pathway [inference]

negative regulation of complement activation, lectin pathway

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

regulation of response to stress [inference]

regulation of defense response [inference]

negative regulation of defense response [inference]

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

regulation of innate immune response [inference]

regulation of complement activation, lectin pathway [inference]

negative regulation of complement activation, lectin pathway

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity

regulation of hydrolase activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
platelet alpha granule lumen	TAS
collagen-containing extracellular matrix	HDA	25037231 28327460 28675934
extracellular region	NAS TAS	14718574
blood microparticle	HDA	22516433
extracellular space	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

platelet alpha granule lumen

intracellular organelle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

platelet alpha granule lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

blood microparticle

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	14687906 32814053 6698368
endopeptidase inhibitor activity	IBA IDA	7679575
interleukin-1 binding	IDA	9714181
signaling receptor binding	IMP	15226301
enzyme binding	IPI	11435418

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding

growth factor binding

interleukin-1 binding

neurotrophin binding [inference]

enzyme binding

protease binding

cytokine binding [inference]

chemokine binding [inference]

C-X-C chemokine binding [inference]

interleukin-8 binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity

serine-type endopeptidase inhibitor activity

peptidase regulator activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity

serine-type endopeptidase inhibitor activity

endopeptidase regulator activity [inference]

endopeptidase inhibitor activity

serine-type endopeptidase inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity

serine-type endopeptidase inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Alpha-2-macroglobulin

Functional Category

O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying 1 entry
Gene Ontology
endopeptidase inhibitor activity

Displaying **all 7** entries
InterPro
Alpha-2-macroglobulin, bait region domain
Alpha-2-macroglobulin
Alpha-macroglobulin, receptor-binding
Alpha-macroglobulin-like, TED domain
Immunoglobulin-like fold
Macroglobulin domain MG3
Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid

Disease

Disease Ontology

Displaying entries **1 - 10** of 17 in total

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DO ID	Disease Name	Source
DOID:0050868	hepatocellular adenoma	Alliance of Genome Resources
DOID:0080600	COVID-19	Alliance of Genome Resources
DOID:10113	trypanosomiasis	Alliance of Genome Resources
DOID:10159	osteonecrosis	Alliance of Genome Resources
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:10976	membranous glomerulonephritis	Alliance of Genome Resources
DOID:114	heart disease	Alliance of Genome Resources
DOID:1184	nephrotic syndrome	Alliance of Genome Resources
DOID:13208	background diabetic retinopathy	Alliance of Genome Resources
DOID:14115	toxic shock syndrome	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 70 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Rattus norvegicus	24153		RGD:2004	RATNO29774
Mus musculus	232345		MGI:2449119	MOUSE50864
Sus scrofa	403166			PIGXX26223
Pan troglodytes	465372	9598_0:0036fb		PANTR05107
Canis lupus familiaris	477699			CANLF11090
Xenopus tropicalis	619586		Xenbase:XB-GENE-481725
Macaca mulatta	716834			MACMU04247
Xenopus tropicalis	779547		Xenbase:XB-GENE-921402
Equus caballus	100061692			HORSE37666
Xenopus laevis	100158443		Xenbase:XB-GENE-6252734

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Tools

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements