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perforin 1 (pore forming protein)

Summary

Gene Symbol

Prf1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

18646

PubChem

18646

Alliance of Genome Resources

MGI:97551

Annotation

Keyword

3D-structure
Calcium
Cell membrane
Cytolysis
Direct protein sequencing
Disulfide bond
EGF-like domain
Endosome
Glycoprotein
Lysosome
Metal-binding
Reference proteome
Secreted
Signal
Transmembrane beta strand

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A2RSY7
P10820	Cytolysin Lymphocyte pore-forming protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
protein transmembrane transport	IDA ISO	21037563
T cell mediated cytotoxicity	IBA IDA IMP	15454490 21037563 26306037 7972104
immunological synapse formation	IBA IEA ISO
immune response to tumor cell	IMP	8164737
circadian rhythm	ISO

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

leukocyte mediated immunity [inference]

leukocyte mediated cytotoxicity [inference]

T cell mediated cytotoxicity

lymphocyte mediated immunity [inference]

T cell mediated immunity [inference]

T cell mediated cytotoxicity

immune response [inference]

adaptive immune response [inference]

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

T cell mediated immunity [inference]

T cell mediated cytotoxicity

immune response to tumor cell

cellular process [inference]

cell killing [inference]

leukocyte mediated cytotoxicity [inference]

T cell mediated cytotoxicity

killing of cells of another organism

signal transduction [inference]

granzyme-mediated programmed cell death signaling pathway

cell recognition [inference]

cell-cell recognition [inference]

immunological synapse formation

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

establishment of protein localization to extracellular region [inference]

protein secretion

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion

transmembrane transport [inference]

protein transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization

export from cell [inference]

secretion by cell [inference]

protein secretion

biological process involved in interspecies interaction between organisms [inference]

modulation of process of another organism [inference]

regulation of killing of cells of another organism [inference]

positive regulation of killing of cells of another organism

response to other organism [inference]

response to virus [inference]

defense response to virus

defense response to other organism [inference]

defense response to symbiont [inference]

defense response to virus

disruption of anatomical structure in another organism [inference]

disruption of cell in another organism [inference]

killing of cells of another organism

rhythmic process [inference]

circadian rhythm

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to tumor cell

defense response to other organism [inference]

defense response to symbiont [inference]

defense response to virus

immune response [inference]

adaptive immune response [inference]

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

T cell mediated immunity [inference]

T cell mediated cytotoxicity

immune response to tumor cell

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus [inference]

defense response to virus

defense response to other organism [inference]

defense response to symbiont [inference]

defense response to virus

response to biotic stimulus [inference]

response to tumor cell [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus [inference]

defense response to virus

defense response to other organism [inference]

defense response to symbiont [inference]

defense response to virus

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

establishment of protein localization to extracellular region [inference]

protein secretion

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion

establishment of localization [inference]

transport [inference]

secretion [inference]

secretion by cell [inference]

protein secretion

transmembrane transport [inference]

protein transmembrane transport

organic substance transport [inference]

protein transport [inference]

nitrogen compound transport [inference]

protein transport [inference]

export from cell [inference]

secretion by cell [inference]

protein secretion

establishment of protein localization [inference]

protein transport [inference]

establishment of protein localization to extracellular region [inference]

protein secretion

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

establishment of protein localization to extracellular region [inference]

protein secretion

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell killing [inference]

positive regulation of killing of cells of another organism

positive regulation of programmed cell death [inference]

positive regulation of killing of cells of another organism

regulation of cellular process [inference]

signal transduction [inference]

granzyme-mediated programmed cell death signaling pathway

regulation of cell killing [inference]

positive regulation of cell killing [inference]

positive regulation of killing of cells of another organism

regulation of killing of cells of another organism [inference]

positive regulation of killing of cells of another organism

regulation of programmed cell death [inference]

positive regulation of programmed cell death [inference]

positive regulation of killing of cells of another organism

positive regulation of cellular process [inference]

positive regulation of cell killing [inference]

positive regulation of killing of cells of another organism

positive regulation of programmed cell death [inference]

positive regulation of killing of cells of another organism

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
cytoplasmic vesicle	IDA	11856751
membrane	IBA IDA ISO	21037563 35148176
plasma membrane	IDA ISO	35705808
extracellular region	IEA
endosome lumen	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endosome lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome [inference]

cytolytic granule

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome [inference]

cytolytic granule

intracellular vesicle [inference]

cytoplasmic vesicle

Displaying **all 4** entries
GO Term	Evidence Code	PMID
pore-forming activity	IEA
identical protein binding	IEA ISO
wide pore channel activity	IBA IDA ISO	21037563 26306037 35148176 35705808
calcium ion binding	IDA	21037563 26306037 35148176

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

passive transmembrane transporter activity [inference]

channel activity [inference]

wide pore channel activity

binding [inference]

protein binding [inference]

identical protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

pore-forming activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

perforin-1

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
T cell mediated cytotoxicity
calcium ion binding
defense response to virus
immunological synapse formation
leukocyte mediated cytotoxicity
wide pore channel activity

Displaying **all 5** entries
InterPro
C2 domain superfamily
C2 domain
Membrane attack complex component/perforin (MACPF) domain
Membrane attack complex component/perforin domain, conserved site
Perforin-1, C2 domain

Disease

Disease Ontology

Displaying entries **1 - 10** of 15 in total

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DO ID	Disease Name	Source
DOID:0060060	non-Hodgkin lymphoma	Alliance of Genome Resources
DOID:0110922	familial hemophagocytic lymphohistiocytosis 2	Alliance of Genome Resources
DOID:12449	aplastic anemia	Alliance of Genome Resources
DOID:13636	Fanconi anemia	Alliance of Genome Resources
DOID:1520	colon carcinoma	Alliance of Genome Resources
DOID:2377	multiple sclerosis	Alliance of Genome Resources
DOID:2841	asthma	Alliance of Genome Resources
DOID:2920	membranoproliferative glomerulonephritis	Alliance of Genome Resources
DOID:2921	glomerulonephritis	Alliance of Genome Resources
DOID:4330	non-Langerhans-cell histiocytosis	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **132** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	5551		HGNC:9360	HUMAN01523
Rattus norvegicus	50669	10116_1:0051ee	RGD:708463	RATNO22057
Bos taurus	369025			BOVIN22480
Sus scrofa	396595			PIGXX07752
Pan troglodytes	450512			PANTR00830
Canis lupus familiaris	489030			CANLF14646
Danio rerio	559384		ZFIN:ZDB-GENE-081105-3
Danio rerio	559849		ZFIN:ZDB-GENE-060503-461
Danio rerio	569443		ZFIN:ZDB-GENE-131127-344	DANRE31139
Macaca mulatta	710241			MACMU45953