GlyCosmos Portal

Annotation

Keyword

Alternative splicing
Endoplasmic reticulum
Hydrolase
Lipid metabolism
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8IWX5	Sphingosine-1-phosphatase 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
regulation of type B pancreatic cell proliferation	ISS
sphingosine metabolic process	IBA IDA	12411432
phospholipid dephosphorylation	IBA
sphingolipid catabolic process

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

sphingolipid catabolic process

sphingoid metabolic process [inference]

sphingosine metabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process

catabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

dephosphorylation [inference]

phospholipid dephosphorylation

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingolipid catabolic process

sphingoid metabolic process [inference]

sphingosine metabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process

lipid modification [inference]

phospholipid dephosphorylation

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingolipid catabolic process

sphingoid metabolic process [inference]

sphingosine metabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process

lipid modification [inference]

phospholipid dephosphorylation

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

diol metabolic process [inference]

sphingosine metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingolipid catabolic process

sphingoid metabolic process [inference]

sphingosine metabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process

lipid modification [inference]

phospholipid dephosphorylation

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

sphingolipid catabolic process

sphingoid metabolic process [inference]

sphingosine metabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

diol metabolic process [inference]

sphingosine metabolic process

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

dephosphorylation [inference]

phospholipid dephosphorylation

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingolipid catabolic process

sphingoid metabolic process [inference]

sphingosine metabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process

lipid modification [inference]

phospholipid dephosphorylation

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

regulation of cell population proliferation [inference]

regulation of epithelial cell proliferation [inference]

regulation of type B pancreatic cell proliferation

Displaying **all 2** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	IDA	12411432
endoplasmic reticulum membrane	IBA TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 2** entries
GO Term	Evidence Code	PMID
dihydrosphingosine-1-phosphate phosphatase activity
sphingosine-1-phosphate phosphatase activity	IBA IDA IMP	12411432 27059959

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity [inference]

lipid phosphatase activity [inference]

sphingosine-1-phosphate phosphatase activity

dihydrosphingosine-1-phosphate phosphatase activity

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K04717

Name

sphingosine-1-phosphate phosphotase 2 [EC:3.1.3.-]

References

12411432

Disease

Disease Ontology

Displaying entries **1 - 10** of 11 in total

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DO ID	Disease Name	Source
DOID:0050589	inflammatory bowel disease	DisGeNET
DOID:0060180	colitis	DisGeNET
DOID:0060189	ileitis	DisGeNET
DOID:0060190	ileocolitis	DisGeNET
DOID:0110892	inflammatory bowel disease 1	DisGeNET
DOID:10534	stomach cancer	DisGeNET
DOID:162	cancer	DisGeNET DisGeNET DisGeNET
DOID:2326	gastroenteritis	DisGeNET
DOID:4766	embryoma	DisGeNET
DOID:5517	stomach carcinoma	DisGeNET

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP005727
Gene Name: sphingosine-1-phosphate phosphatase 2

Ortholog

Displaying entries **1 - 10** of 70 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Lepisosteus oculatus	102693517		LEPOC04201
Danio rerio	100330698	ZFIN:ZDB-GENE-120221-2	DANRE09758
Astyanax mexicanus	103045304		ASTMX19089
Ictalurus punctatus	108277997		ICTPU10011
Esox lucius	105017512		ESOLU00835
Gadus morhua	115560836		GADMO18813
Poecilia reticulata	103474930		POERE06768
Oryzias latipes	101156907		ORYLA03513
Oreochromis niloticus	100698709		ORENI17319
Haplochromis burtoni	102298213		HAPBU11948

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Tools

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Summary

External Links

Annotation

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements