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sphingosine-1-phosphate phosphatase 2

Summary

Gene Symbol

SGPP2

Aliases

FLJ39004
SPP2

Organism

Homo sapiens (human)

External Links

NCBI Gene

130367

HGNC

19953

KEGG Gene ID

hsa:130367

PubChem

130367

Alliance of Genome Resources

HGNC:19953

Annotation

Keyword

Alternative splicing
Endoplasmic reticulum
Hydrolase
Lipid metabolism
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8IWX5	Sphingosine-1-phosphatase 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
sphingolipid catabolic process
sphingosine metabolic process	IBA IDA	12411432
phospholipid dephosphorylation	IBA
regulation of type B pancreatic cell proliferation	ISS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

sphingolipid catabolic process

sphingoid metabolic process [inference]

sphingosine metabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process

catabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

dephosphorylation [inference]

phospholipid dephosphorylation

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingolipid catabolic process

sphingoid metabolic process [inference]

sphingosine metabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process

lipid modification [inference]

phospholipid dephosphorylation

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingolipid catabolic process

sphingoid metabolic process [inference]

sphingosine metabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process

lipid modification [inference]

phospholipid dephosphorylation

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

diol metabolic process [inference]

sphingosine metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingolipid catabolic process

sphingoid metabolic process [inference]

sphingosine metabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process

lipid modification [inference]

phospholipid dephosphorylation

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

sphingolipid catabolic process

sphingoid metabolic process [inference]

sphingosine metabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

diol metabolic process [inference]

sphingosine metabolic process

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

dephosphorylation [inference]

phospholipid dephosphorylation

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingolipid catabolic process

sphingoid metabolic process [inference]

sphingosine metabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process

lipid modification [inference]

phospholipid dephosphorylation

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

regulation of cell population proliferation [inference]

regulation of epithelial cell proliferation [inference]

regulation of type B pancreatic cell proliferation

Displaying **all 2** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum membrane	IBA TAS
endoplasmic reticulum	IDA	12411432

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 2** entries
GO Term	Evidence Code	PMID
dihydrosphingosine-1-phosphate phosphatase activity	IEA
sphingosine-1-phosphate phosphatase activity	IBA IDA IMP TAS	12411432 27059959

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity [inference]

lipid phosphatase activity [inference]

sphingosine-1-phosphate phosphatase activity

dihydrosphingosine-1-phosphate phosphatase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Sphingosine-1-phosphate phosphatase

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
hydrolase activity
sphingosine metabolic process
sphingosine-1-phosphate phosphatase activity

Displaying **all 2** entries
InterPro
Phosphatidic acid phosphatase type 2/haloperoxidase superfamily
Phosphatidic acid phosphatase type 2/haloperoxidase

KEGG BRITE Database

Orthology

K04717

Name

sphingosine-1-phosphate phosphotase 2 [EC:3.1.3.-]

References

12411432

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP005727
Gene Name: sphingosine-1-phosphate phosphatase 2

Ortholog

Displaying entries **71 - 73** of 73 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Balaenoptera musculus	118897939		BALMU00846
Panthera leo	122226696		PANLE10583
Pongo pygmaeus	129031254	9600_0:000d3a

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Summary

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Annotation

OrthoDB (Group)

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements