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cortactin

Summary

Gene Symbol

Cttn

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

13043

PubChem

13043

Alliance of Genome Resources

MGI:99695

Annotation

Keyword

3D-structure
Acetylation
Cell junction
Cell membrane
Cell projection
Coated pit
Coiled coil
Cytoskeleton
Direct protein sequencing
Endocytosis
Endoplasmic reticulum
Isopeptide bond
Methylation
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
SH3 domain
Synapse
Ubl conjugation

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q60598
Q921L6
Q8BNA5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 32 in total

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GO Term	Evidence Code	PMID
intracellular protein transport	ISS
intracellular protein transport	ISO
intracellular protein transport	IMP	17959782
receptor-mediated endocytosis	ISS
receptor-mediated endocytosis	ISO

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

extrinsic apoptotic signaling pathway

apoptotic signaling pathway [inference]

extrinsic apoptotic signaling pathway

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis

actin filament-based process [inference]

actin cytoskeleton organization

cell motility

cell migration

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization

cellular component assembly [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

substrate-dependent cell migration, cell extension

cell junction assembly [inference]

cell-substrate junction assembly [inference]

focal adhesion assembly

cell projection organization [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

substrate-dependent cell migration, cell extension

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis

plasma membrane bounded cell projection organization [inference]

lamellipodium organization

neuron projection organization [inference]

dendritic spine organization [inference]

dendritic spine maintenance

plasma membrane bounded cell projection assembly [inference]

substrate-dependent cell migration, cell extension

regulation of cellular component size [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization

positive regulation of actin filament polymerization

cell junction organization [inference]

cell junction assembly [inference]

cell-substrate junction assembly [inference]

focal adhesion assembly

synapse organization [inference]

modification of synaptic structure [inference]

modification of postsynaptic structure

modification of postsynaptic actin cytoskeleton

cell-substrate junction organization [inference]

cell-substrate junction assembly [inference]

focal adhesion assembly

cellular component maintenance [inference]

dendritic spine maintenance

postsynapse organization [inference]

dendritic spine organization [inference]

dendritic spine maintenance

developmental process [inference]

anatomical structure morphogenesis [inference]

cellular anatomical entity morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis

intracellular transport [inference]

intracellular protein transport

organic substance transport [inference]

protein transport [inference]

intracellular protein transport

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of catabolic process [inference]

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

regulation of macroautophagy [inference]

regulation of mitophagy

regulation of autophagy of mitochondrion [inference]

regulation of mitophagy

regulation of cellular metabolic process [inference]

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

regulation of macroautophagy [inference]

regulation of mitophagy

regulation of autophagy of mitochondrion [inference]

regulation of mitophagy

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

regulation of extrinsic apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

regulation of growth [inference]

regulation of cell growth [inference]

regulation of extent of cell growth [inference]

regulation of axon extension

regulation of developmental growth [inference]

regulation of axon extension

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of chemotaxis

regulation of chemotaxis [inference]

positive regulation of chemotaxis

positive regulation of biological process [inference]

positive regulation of locomotion [inference]

positive regulation of chemotaxis

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of actin filament polymerization

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin filament polymerization

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of actin filament polymerization

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin filament polymerization

positive regulation of response to stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of chemotaxis

positive regulation of multicellular organismal process [inference]

positive regulation of muscle contraction [inference]

positive regulation of smooth muscle contraction

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

regulation of extrinsic apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of chemotaxis

regulation of chemotaxis [inference]

positive regulation of chemotaxis

positive regulation of response to stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of chemotaxis

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

regulation of developmental process [inference]

regulation of developmental growth [inference]

regulation of axon extension

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

extrinsic apoptotic signaling pathway

apoptotic signaling pathway [inference]

extrinsic apoptotic signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

regulation of extrinsic apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

regulation of cellular metabolic process [inference]

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

regulation of macroautophagy [inference]

regulation of mitophagy

regulation of autophagy of mitochondrion [inference]

regulation of mitophagy

regulation of actin filament-based process [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization

positive regulation of actin filament polymerization

regulation of actin filament organization [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization

positive regulation of actin filament polymerization

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

regulation of extrinsic apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of actin filament polymerization

regulation of protein polymerization [inference]

regulation of actin filament polymerization

positive regulation of actin filament polymerization

positive regulation of protein polymerization [inference]

positive regulation of actin filament polymerization

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of actin filament polymerization

regulation of cell projection assembly

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of actin filament polymerization

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin filament polymerization

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of actin filament polymerization

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin filament polymerization

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of extrinsic apoptotic signaling pathway

regulation of cellular component organization [inference]

regulation of cell growth [inference]

regulation of extent of cell growth [inference]

regulation of axon extension

regulation of cell projection organization [inference]

regulation of cell projection assembly

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin filament polymerization

regulation of mitochondrion organization [inference]

regulation of autophagy of mitochondrion [inference]

regulation of mitophagy

regulation of cytoskeleton organization [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization

positive regulation of actin filament polymerization

regulation of actin filament organization [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization

positive regulation of actin filament polymerization

positive regulation of cytoskeleton organization [inference]

positive regulation of actin filament polymerization

regulation of protein-containing complex assembly [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of actin filament polymerization

regulation of protein polymerization [inference]

regulation of actin filament polymerization

positive regulation of actin filament polymerization

positive regulation of protein polymerization [inference]

positive regulation of actin filament polymerization

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin filament polymerization

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of actin filament polymerization

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin filament polymerization

regulation of supramolecular fiber organization [inference]

regulation of actin filament organization [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization

positive regulation of actin filament polymerization

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin filament polymerization

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of muscle system process [inference]

regulation of muscle contraction [inference]

regulation of smooth muscle contraction [inference]

positive regulation of smooth muscle contraction

positive regulation of muscle contraction [inference]

positive regulation of smooth muscle contraction

positive regulation of multicellular organismal process [inference]

positive regulation of muscle contraction [inference]

positive regulation of smooth muscle contraction

regulation of biological quality [inference]

regulation of anatomical structure size [inference]

regulation of cellular component size [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization

positive regulation of actin filament polymerization

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GO Term	Evidence Code	PMID
ruffle	IDA	10637315 12913069
podosome	IDA	17893324
cytoplasm	ISO
cytoplasm	IDA	12913069
endoplasmic reticulum	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

voltage-gated potassium channel complex

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

potassium channel complex [inference]

voltage-gated potassium channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

potassium channel complex [inference]

voltage-gated potassium channel complex

cellular anatomical entity [inference]

cytoplasm

cell cortex

cytosol

membrane [inference]

plasma membrane

plasma membrane region [inference]

clathrin-coated pit

cell junction

synapse [inference]

glutamatergic synapse

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

site of polarized growth

growth cone

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

neuron spine [inference]

dendritic spine

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

podosome

cytoskeleton [inference]

actin cytoskeleton [inference]

postsynaptic actin cytoskeleton

cortical cytoskeleton

cortical actin cytoskeleton

postsynaptic cytoskeleton [inference]

postsynaptic actin cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle

intracellular non-membrane-bounded organelle [inference]

podosome

cytoskeleton [inference]

actin cytoskeleton [inference]

postsynaptic actin cytoskeleton

cortical cytoskeleton

cortical actin cytoskeleton

postsynaptic cytoskeleton [inference]

postsynaptic actin cytoskeleton

spindle midzone [inference]

mitotic spindle midzone

postsynapse

dendritic spine

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

actin filament

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GO Term	Evidence Code	PMID
protein binding	IPI	11018051 11018064 11231575 12620186 12732638 12913069 15169891 15585574 15688017 17065230 17318189 17451412 17576929 17606906 17959782 19414610 21847094 22252131 22282019 24574519 31600191
profilin binding	ISO
profilin binding	IEA
actin filament binding	IBA
proline-rich region binding	ISO

GO Hierarchy

molecular function

binding [inference]

protein binding

profilin binding

cytoskeletal protein binding [inference]

actin binding [inference]

actin filament binding

proline-rich region binding

protein-containing complex binding [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

src substrate cortactin

Functional Category

C: Energy production and conversion
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
actin filament binding
regulation of actin filament polymerization

Displaying **all 4** entries
InterPro
Cortactin, SH3 domain
Hs1/Cortactin
SH3 domain
SH3-like domain superfamily

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Saccharomyces cerevisiae S288C	1627	SGD:S000000684
Homo sapiens	2017	Xenbase:XB-GENE-492434	HUMAN07809
Saccharomyces cerevisiae S288C	3059	SGD:S000000684
Xenopus tropicalis	13043	Xenbase:XB-GENE-492434
Saccharomyces cerevisiae S288C	13169	SGD:S000000684
Saccharomyces cerevisiae S288C	28988	SGD:S000000684
Saccharomyces cerevisiae S288C	56320	SGD:S000000684
Rattus norvegicus	60465		RATNO20544
Bos taurus	506939		BOVIN23647
Canis lupus familiaris	610283		CANLF05940

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements