GlyCosmos Portal

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GO Term	Evidence Code	PMID
dopamine beta-monooxygenase activity	ISS
dopamine beta-monooxygenase activity	ISO
dopamine beta-monooxygenase activity	IBA
copper ion binding	ISS
copper ion binding	ISO

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

monooxygenase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen [inference]

dopamine beta-monooxygenase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen [inference]

dopamine beta-monooxygenase activity

binding [inference]

carbohydrate binding [inference]

monosaccharide binding [inference]

L-ascorbic acid binding

small molecule binding [inference]

vitamin binding [inference]

L-ascorbic acid binding

organic acid binding [inference]

carboxylic acid binding [inference]

L-ascorbic acid binding

monosaccharide binding [inference]

L-ascorbic acid binding

heterocyclic compound binding [inference]

L-ascorbic acid binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

L-ascorbic acid binding

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

copper ion binding

organic cyclic compound binding [inference]

L-ascorbic acid binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

DBH-like monooxygenase protein 1-like protein

Functional Category

C: Energy production and conversion
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 9** entries
Gene Ontology
catalytic activity
copper ion binding
dopamine beta-monooxygenase activity
dopamine catabolic process
metal ion binding
monooxygenase activity
norepinephrine biosynthetic process
octopamine biosynthetic process
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen

Displaying **all 10** entries
InterPro
Copper type II ascorbate-dependent monooxygenase, C-terminal
Copper type II, ascorbate-dependent monooxygenase, N-terminal domain superfamily
Copper type II, ascorbate-dependent monooxygenase, N-terminal
Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-1 conserved site
Copper type II, ascorbate-dependent monooxygenase-like, C-terminal
Copper-dependent monooxygenases, DOMON domain
DOMON domain
Dopamine beta-hydroxylase-like
PHM/PNGase F domain superfamily
Tyramine beta-hydroxylase/Dopamine beta-hydroxylase

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0090145	dopamine beta-hydroxylase deficiency	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 68 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	1621	Xenbase:XB-GENE-959495	HUMAN99160
Xenopus tropicalis	13166	Xenbase:XB-GENE-959495
Rattus norvegicus	25699	Xenbase:XB-GENE-959495	RATNO27198
Danio rerio	30505		DANRE01383
Xenopus tropicalis	31718	Xenbase:XB-GENE-959495
Xenopus tropicalis	181639	Xenbase:XB-GENE-959495
Bos taurus	280758		BOVIN03453
Canis lupus familiaris	448806		CANLF19309
Pan troglodytes	464827		PANTR45178
Macaca mulatta	574105		MACMU12138

GlyTouCan

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Annotation

OrthoDB (Group)

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Acknowledgements