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crystallin alpha A

Summary

Gene Symbol

CRYAA

Organism

Homo sapiens (human)

External Links

NCBI Gene

1409

PubChem

1409

Alliance of Genome Resources

HGNC:2388

Annotation

Keyword

3D-structure
Acetylation
Cataract
Chaperone
Cytoplasm
Direct protein sequencing
Disease variant
Disulfide bond
Eye lens protein
Glycoprotein
Metal-binding
Nucleus
Oxidation
Phosphoprotein
Reference proteome
Vision
Zinc

Proteins

Displaying 1 entry
UniProt	Protein Name
P02489	Heat shock protein beta-4 Heat shock protein family B member 4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
lens development in camera-type eye	IBA
visual perception	IMP	14512969 9467006
response to heat	IBA
negative regulation of intracellular transport	IDA	14752512
protein refolding	ISS

GO Hierarchy

biological process

cellular process [inference]

protein folding [inference]

protein refolding

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of light stimulus [inference]

visual perception

developmental process [inference]

anatomical structure development [inference]

lens development in camera-type eye

response to stimulus [inference]

response to stress [inference]

response to heat

response to abiotic stimulus [inference]

response to temperature stimulus [inference]

response to heat

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of intracellular transport [inference]

negative regulation of intracellular transport

negative regulation of transport [inference]

negative regulation of intracellular transport

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

negative regulation of intracellular transport

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of intracellular transport

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of transport [inference]

negative regulation of intracellular transport

regulation of cellular process [inference]

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of cellular process [inference]

negative regulation of intracellular transport

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

negative regulation of intracellular transport

regulation of biological quality [inference]

regulation of protein stability [inference]

protein stabilization

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
nucleus	IDA	19464326
nucleus	IBA
nucleoplasm	IDA
cytoplasm	IDA	14752512 19464326 19503744 26004348 29259299 30340470
cytoplasm	IBA

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
structural molecule activity	IDA	16303126
structural constituent of eye lens	IEA
protein binding	IPI	11700327 12235146 12601044 14752512 19651604 22085609 22153508 23188086 25416956 25910212 29892012 31515488 32296183 32814053 33961781
identical protein binding	IPI	12601044 16303126 19651604 22085609 25416956 32296183
metal ion binding	IEA

GO Hierarchy

molecular function

structural molecule activity

structural constituent of eye lens

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Heat Shock Protein

Functional Category

O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
unfolded protein binding

Displaying **all 2** entries
InterPro
Alpha crystallin/Hsp20 domain
HSP20-like chaperone

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0110266	cataract 9 multiple types	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of 85 in total

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Species	Gene ID	Orthologous MAtrix
Bos taurus	281718	BOVIN15454
Pan troglodytes	458589	PANTR25772
Canis lupus familiaris	487786	CANLF12914
Macaca mulatta	722370	MACMU31514
Ornithorhynchus anatinus	791110	ORNAN09637
Danio rerio	100000769	DANRE17634
Monodelphis domestica	100014565	MONDO23277
Oryzias latipes	100049490	ORYLA19839
Equus caballus	100051134	HORSE24803
Cavia porcellus	100135506	CAVPO21349

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Annotation

OrthoDB (Group)

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Acknowledgements