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fucosyltransferase 1

Summary

Gene Symbol

Fut1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

14343

KEGG Gene ID

mmu:14343

PubChem

14343

Alliance of Genome Resources

MGI:109375

Annotation

Keyword

Glycoprotein
Glycosyltransferase
Golgi apparatus
Lipid metabolism
Proteomics identification
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q32MG3
O09160	Alpha(1,2)FT 1 Fucosyltransferase 1 GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1 Type 1 galactoside alpha-(1,2)-fucosyltransferase FUT1 Type 2 galactoside alpha-(1,2)-fucosyltransferase FUT1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
oligosaccharide biosynthetic process	IMP	11713270
positive regulation of sprouting angiogenesis	ISO
olfactory bulb development	IMP	16884711
regulation of endothelial cell proliferation	IMP	20506485
carbohydrate metabolic process	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

biosynthetic process [inference]

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

primary metabolic process [inference]

carbohydrate metabolic process

oligosaccharide metabolic process [inference]

oligosaccharide biosynthetic process

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

lipid metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

glycosylation [inference]

fucosylation

macromolecule glycosylation [inference]

protein glycosylation

organic substance metabolic process [inference]

carbohydrate metabolic process

oligosaccharide metabolic process [inference]

oligosaccharide biosynthetic process

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

lipid metabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation

macromolecule glycosylation [inference]

protein glycosylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

developmental process [inference]

anatomical structure development [inference]

olfactory bulb development

biological regulation [inference]

regulation of biological process [inference]

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of epithelial cell migration [inference]

regulation of endothelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of biological process [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of cellular process [inference]

positive regulation of cell adhesion [inference]

positive regulation of cell-substrate adhesion [inference]

positive regulation of cell-matrix adhesion

positive regulation of endothelial cell-matrix adhesion via fibronectin

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of developmental process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis [inference]

positive regulation of sprouting angiogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis [inference]

positive regulation of sprouting angiogenesis

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis [inference]

positive regulation of sprouting angiogenesis

regulation of sprouting angiogenesis [inference]

positive regulation of sprouting angiogenesis

positive regulation of developmental process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis [inference]

positive regulation of sprouting angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis [inference]

positive regulation of sprouting angiogenesis

regulation of sprouting angiogenesis [inference]

positive regulation of sprouting angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis [inference]

positive regulation of sprouting angiogenesis

regulation of cellular process [inference]

regulation of cell adhesion

regulation of cell-substrate adhesion [inference]

regulation of cell-matrix adhesion [inference]

positive regulation of cell-matrix adhesion

positive regulation of endothelial cell-matrix adhesion via fibronectin

regulation of endothelial cell-matrix adhesion via fibronectin [inference]

positive regulation of endothelial cell-matrix adhesion via fibronectin

positive regulation of cell-substrate adhesion [inference]

positive regulation of cell-matrix adhesion

positive regulation of endothelial cell-matrix adhesion via fibronectin

positive regulation of cell adhesion [inference]

positive regulation of cell-substrate adhesion [inference]

positive regulation of cell-matrix adhesion

positive regulation of endothelial cell-matrix adhesion via fibronectin

regulation of cell population proliferation [inference]

regulation of epithelial cell proliferation [inference]

regulation of endothelial cell proliferation

positive regulation of cellular process [inference]

positive regulation of cell adhesion [inference]

positive regulation of cell-substrate adhesion [inference]

positive regulation of cell-matrix adhesion

positive regulation of endothelial cell-matrix adhesion via fibronectin

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of epithelial cell migration [inference]

regulation of endothelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

regulation of multicellular organismal process [inference]

regulation of epithelial cell migration [inference]

regulation of endothelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of multicellular organismal process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis [inference]

positive regulation of sprouting angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis [inference]

positive regulation of sprouting angiogenesis

regulation of sprouting angiogenesis [inference]

positive regulation of sprouting angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis [inference]

positive regulation of sprouting angiogenesis

Displaying **all 3** entries
GO Term	Evidence Code	PMID
membrane	IEA
Golgi apparatus	IMP	11713270
Golgi cisterna membrane

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

Golgi cisterna membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

Displaying **all 5** entries
GO Term	Evidence Code	PMID
glycosyltransferase activity	IEA
alpha-(1,2)-fucosyltransferase activity	IDA	11368156 14967068
transferase activity	IEA
fucosyltransferase activity	IMP	11713270
galactoside 2-alpha-L-fucosyltransferase activity	IBA IDA	9355741

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity

glycosyltransferase activity

hexosyltransferase activity [inference]

fucosyltransferase activity

alpha-(1,2)-fucosyltransferase activity

galactoside 2-alpha-L-fucosyltransferase activity

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K00718

Name

galactoside 2-L-fucosyltransferase 1/2 [EC:2.4.1.69]

References

Reactions

Displaying entries **1 - 10** of 12 in total

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KEGG Reaction	Enzyme	Acceptor	Product
R06085	2.4.1.69	G98726UE	G98900YM
R06156	2.4.1.69	G00049MO	G00050MO
R06089	2.4.1.69	G98726UE	G28261RX
R06086	2.4.1.69	G98900YM	G87164WU
R06090	2.4.1.69	G28261RX	G87164WU
R06035	2.4.1.69	G84034JH	G66427ZQ
R06170	2.4.1.69	G56390QA	G63238VS
R05968	2.4.1.69	G99053DY	G98465JN
R06024	2.4.1.69	G58896AZ	G13636IT
R06031	2.4.1.69	G64885AH	G58990QD

Rhea

RHEA:50668

a β-D-galactosyl-(1→4)-N-acetyl-β-D-glucosaminyl derivative + GDP-β-L-fucose

an α-L-Fuc-(1→2)-β-D-Gal-(1→4)-β-D-GlcNAc derivative + H⁺ + GDP

Enzyme

2.4.1.344

PMID

RHEA:50664

a β-D-galactosyl-(1→3)-N-acetyl-β-D-glucosaminyl derivative + GDP-β-L-fucose

an α-L-Fuc-(1→2)-β-D-Gal-(1→3)-β-D-GlcNAc derivative + H⁺ + GDP

Enzyme

2.4.1.69

PMID

RHEA:32175

a β-D-Gal-(1→3)-β-D-GlcNAc-(1→3)-β-D-Gal-(1→4)-β-D-Glc-(1↔1ʼ)-Cer(d18:1(4E)) + GDP-β-L-fucose

H⁺ + α-L-fucosyl-(1→2)- β-D-galactosyl-(1→3)-N-acetyl-β-D-glucosaminyl-(1→3)-β-D-galactosyl-(1→4)-β-D-glucosyl-(1↔1ʼ)-N-acylsphing-4-enine + GDP

Enzyme

2.4.1.69

PMID

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP002033
Gene Name: fucosyltransferase 1

Ortholog

Displaying entries **1 - 10** of 39 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	172980	WB:WBGene00015019
Caenorhabditis elegans	182700	WB:WBGene00015872
Caenorhabditis elegans	182798	WB:WBGene00015986
Caenorhabditis elegans	184168	WB:WBGene00008568
Caenorhabditis elegans	185174	WB:WBGene00017963
Caenorhabditis elegans	189361	WB:WBGene00021164
Xenopus tropicalis	447958	Xenbase:XB-GENE-986117
Callithrix jacchus	100389529		CALJA24553
Cercocebus atys	105595255		CERAT28506
Macaca mulatta	718252		MACMU18098