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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
gap junction protein, alpha 1
Summary
- Gene Symbol
-
- Gja1
- Organism
- Mus musculus (house mouse)
Annotation
- Keyword
-
- Acetylation
- Cell membrane
- Disulfide bond
- Endoplasmic reticulum
- Gap junction
- Isopeptide bond
- Phosphoprotein
- Reference proteome
- S-nitrosylation
- Transmembrane helix
- Ubl conjugation
- Proteins
| UniProt | Protein Name |
|---|---|
| P23242 |
|
| Q8C4N2 |
|
| A0A654ICD2 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| ATP transport | ||
| positive regulation of vasoconstriction | ||
| cellular response to mechanical stimulus | ||
| regulation of bicellular tight junction assembly | ||
| embryonic heart tube development |
GO Hierarchy
- signal transduction
biological process
cellular process [inference]
developmental process [inference]
response to stimulus [inference]
localization [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of localization [inference]
regulation of growth [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of cellular metabolic process [inference]
regulation of cell population proliferation [inference]
regulation of cell differentiation [inference]
positive regulation of cellular process [inference]
negative regulation of cellular process [inference]
regulation of multicellular organismal process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| cell junction | ||
| multivesicular body | ||
| membrane | ||
| early endosome | ||
| Golgi apparatus |
| GO Term | Evidence Code | PMID |
|---|---|---|
| glutathione transmembrane transporter activity | ||
| protein binding | ||
| protein tyrosine kinase binding | ||
| SH3 domain binding | ||
| signaling receptor binding |
OrthoDB (Group)
- Group level
- Rodentia
- Group Name
- gap junction alpha-1 protein
- Functional Category
-
- C: Energy production and conversion
- I: Lipid transport and metabolism
- P: Inorganic ion transport and metabolism
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| cell communication by electrical coupling |
| cell communication |
| cell-cell signaling |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050431 | arrhythmogenic right ventricular cardiomyopathy | |
| DOID:0050467 | erythrokeratodermia variabilis | |
| DOID:0050865 | tongue squamous cell carcinoma | |
| DOID:0060224 | atrial fibrillation | |
| DOID:0060291 | oculodentodigital dysplasia | |
| DOID:0070355 | overactive bladder syndrome | |
| DOID:0080249 | erythrokeratodermia variabilis et progressiva 3 | |
| DOID:0080802 | autosomal recessive craniometaphyseal dysplasia | |
| DOID:0080855 | Parkinsonism | |
| DOID:0111244 | palmoplantar keratoderma and congenital alopecia 1 |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 2697 | HGNC:4274 | HUMAN86312 | ||
| 24392 | 10116_1:005384 | RGD:2690 | RATNO22619 | |
| 30236 | ZFIN:ZDB-GENE-991105-4 | DANRE20228 | ||
| 281193 | BOVIN35451 | |||
| 394450 | Xenbase:XB-GENE-876602 | |||
| 403418 | CANLF00319 | |||
| 565638 | ZFIN:ZDB-GENE-050616-10 | |||
| 714344 | MACMU34332 | |||
| 736481 | PANTR35881 | |||
| 100008935 | RABIT02792 |
