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Gap junction alpha-1 protein

Summary

UniProt ID

P23242

Gene Symbol

Cxn-43
Gja1

Gene ID

14609

Organism

Mus musculus (house mouse)

External Links

GlyGen: P23242
PubChem: P23242
Re-Glyco: P23242

Annotation

Keyword

Acetylation
Cell membrane
Disulfide bond
Endoplasmic reticulum
Gap junction
Isopeptide bond
Phosphoprotein
Reference proteome
S-nitrosylation
Transmembrane helix
Ubl conjugation

Gene Ontology (GO)

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GO Term
cytoplasm
cytosol
apical plasma membrane
mitochondrial outer membrane
multivesicular body
fascia adherens
gap junction
intercalated disc
lateral plasma membrane
membrane raft

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

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GO Term
bone development
positive regulation of morphogenesis of an epithelium
in utero embryonic development
neuron migration
chronic inflammatory response
positive regulation of glomerular filtration
signal transduction
cell-cell signaling
atrial ventricular junction remodeling
epicardial cell to mesenchymal cell transition

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GO Term
signaling receptor binding
beta-catenin binding
efflux transmembrane transporter activity
tubulin binding
PDZ domain binding
glutathione transmembrane transporter activity
disordered domain specific binding
monoatomic ion transmembrane transporter activity
connexin binding
gap junction channel activity involved in cardiac conduction electrical coupling

Annotation information from UniProt.

Sequence

MGDWSALGKLLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFRCNTQQPGCENVCYDKSFPISHVRFWVLQIIFVSVPTLLYLAHVFYVMRKEEKLNKKEEELKVAQTDGVNVEMHLKQIEIKKFKYGIEEHGKVKMRGGLLRTYIISILFKSVFEVAFLLIQWYIYGFSLSAVYTCKRDPCPHQVDCFLSRPTEKTIFIIFMLVVSLVSLALNIIELFYVFFKGVKDRVKGRSDPYHATTGPLSPSKDCGSPKYAYFNGCSSPTAPLSPMSPPGYKLVTGDRNNSSCRNYNKQASEQNWANYSAEQNRMGQAGSTISNSHAQPFDFPDDSQNAKKVAAGHELQPLAIVDQRPSSRASSRASSRPRPDDLEI

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
312			G02815KT	GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 6** entries
Pathway Name	Organism
Formation of annular gap junctions	Mus musculus
Gap junction assembly	Mus musculus
Gap junction degradation	Mus musculus
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	Mus musculus
RHOQ GTPase cycle	Mus musculus
Regulation of gap junction activity	Mus musculus