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5-hydroxytryptamine (serotonin) receptor 1B

Summary

Gene Symbol

Htr1b

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

15551

PubChem

15551

Alliance of Genome Resources

MGI:96274

Annotation

Keyword

Behavior
Cell membrane
Disulfide bond
G-protein coupled receptor
Glycoprotein
Palmitate
Phosphoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q0VES5	Serotonin receptor 1B
P28334	Serotonin receptor 1B

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 42 in total

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GO Term	Evidence Code	PMID
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISO
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA
adenylate cyclase-inhibiting serotonin receptor signaling pathway	ISS
adenylate cyclase-inhibiting serotonin receptor signaling pathway	ISO

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

adenylate cyclase-inhibiting serotonin receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway [inference]

phospholipase C-activating serotonin receptor signaling pathway

G protein-coupled serotonin receptor signaling pathway [inference]

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organonitrogen compound [inference]

cellular response to alkaloid

cellular response to xenobiotic stimulus

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to alkaloid

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

vasoconstriction

behavior [inference]

feeding behavior

drinking behavior

tissue remodeling [inference]

bone remodeling

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

regulation of cytosolic calcium ion concentration [inference]

regulation of presynaptic cytosolic calcium ion concentration

neuron cellular homeostasis [inference]

regulation of presynaptic cytosolic calcium ion concentration

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

regulation of cytosolic calcium ion concentration [inference]

regulation of presynaptic cytosolic calcium ion concentration

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

regulation of cytosolic calcium ion concentration [inference]

regulation of presynaptic cytosolic calcium ion concentration

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis [inference]

regulation of cytosolic calcium ion concentration [inference]

regulation of presynaptic cytosolic calcium ion concentration

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

regulation of cytosolic calcium ion concentration [inference]

regulation of presynaptic cytosolic calcium ion concentration

inorganic ion homeostasis [inference]

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis [inference]

regulation of cytosolic calcium ion concentration [inference]

regulation of presynaptic cytosolic calcium ion concentration

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to mineralocorticoid

cellular response to endogenous stimulus [inference]

cellular response to organonitrogen compound [inference]

cellular response to alkaloid

response to chemical [inference]

response to xenobiotic stimulus [inference]

cellular response to xenobiotic stimulus

response to toxic substance

response to organic substance [inference]

response to hormone [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to mineralocorticoid

response to organonitrogen compound [inference]

response to alkaloid [inference]

cellular response to organonitrogen compound [inference]

cellular response to alkaloid

response to organic cyclic compound [inference]

response to cocaine

response to steroid hormone [inference]

response to corticosteroid [inference]

response to mineralocorticoid

response to lipid [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to mineralocorticoid

cellular response to organic substance [inference]

cellular response to organonitrogen compound [inference]

cellular response to alkaloid

response to alcohol [inference]

response to ethanol

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organonitrogen compound [inference]

cellular response to alkaloid

cellular response to xenobiotic stimulus

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to alkaloid

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to alkaloid [inference]

cellular response to organonitrogen compound [inference]

cellular response to alkaloid

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to alkaloid

response to oxygen-containing compound [inference]

response to cocaine

response to alcohol [inference]

response to ethanol

response to salt [inference]

response to cocaine

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organonitrogen compound [inference]

cellular response to alkaloid

cellular response to xenobiotic stimulus

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to alkaloid

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

negative regulation of signaling [inference]

negative regulation of synaptic transmission [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic transmission, GABAergic [inference]

negative regulation of synaptic transmission, GABAergic

regulation of neurotransmitter secretion [inference]

regulation of synaptic vesicle exocytosis

negative regulation of synaptic transmission [inference]

regulation of synaptic transmission, glutamatergic [inference]

negative regulation of synaptic transmission, glutamatergic

presynaptic modulation of chemical synaptic transmission

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

regulation of localization [inference]

regulation of transport [inference]

regulation of organic acid transport [inference]

negative regulation of organic acid transport [inference]

negative regulation of amino acid transport [inference]

negative regulation of gamma-aminobutyric acid secretion

regulation of amino acid transport [inference]

regulation of gamma-aminobutyric acid secretion [inference]

negative regulation of gamma-aminobutyric acid secretion

negative regulation of amino acid transport [inference]

negative regulation of gamma-aminobutyric acid secretion

regulation of monoatomic ion transport [inference]

regulation of serotonin secretion [inference]

negative regulation of serotonin secretion

negative regulation of monoatomic ion transport [inference]

negative regulation of serotonin secretion

regulation of secretion [inference]

regulation of gamma-aminobutyric acid secretion [inference]

negative regulation of gamma-aminobutyric acid secretion

negative regulation of secretion [inference]

negative regulation of gamma-aminobutyric acid secretion

negative regulation of secretion by cell [inference]

negative regulation of serotonin secretion

regulation of secretion by cell [inference]

regulation of serotonin secretion [inference]

negative regulation of serotonin secretion

regulation of exocytosis [inference]

regulation of regulated secretory pathway [inference]

regulation of synaptic vesicle exocytosis

regulation of neurotransmitter secretion [inference]

regulation of synaptic vesicle exocytosis

regulation of catecholamine secretion [inference]

regulation of dopamine secretion

negative regulation of secretion by cell [inference]

negative regulation of serotonin secretion

negative regulation of transport [inference]

negative regulation of organic acid transport [inference]

negative regulation of amino acid transport [inference]

negative regulation of gamma-aminobutyric acid secretion

negative regulation of monoatomic ion transport [inference]

negative regulation of serotonin secretion

negative regulation of secretion [inference]

negative regulation of gamma-aminobutyric acid secretion

negative regulation of secretion by cell [inference]

negative regulation of serotonin secretion

negative regulation of amine transport [inference]

negative regulation of amino acid transport [inference]

negative regulation of gamma-aminobutyric acid secretion

regulation of neurotransmitter transport [inference]

regulation of neurotransmitter secretion [inference]

regulation of synaptic vesicle exocytosis

regulation of amine transport [inference]

regulation of catecholamine secretion [inference]

regulation of dopamine secretion

negative regulation of amine transport [inference]

negative regulation of amino acid transport [inference]

negative regulation of gamma-aminobutyric acid secretion

regulation of amino acid transport [inference]

regulation of gamma-aminobutyric acid secretion [inference]

negative regulation of gamma-aminobutyric acid secretion

negative regulation of amino acid transport [inference]

negative regulation of gamma-aminobutyric acid secretion

regulation of vesicle-mediated transport [inference]

regulation of exocytosis [inference]

regulation of regulated secretory pathway [inference]

regulation of synaptic vesicle exocytosis

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of smooth muscle cell proliferation [inference]

positive regulation of vascular associated smooth muscle cell proliferation

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of synaptic transmission [inference]

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of synaptic transmission [inference]

negative regulation of secretion by cell [inference]

negative regulation of serotonin secretion

negative regulation of transport [inference]

negative regulation of organic acid transport [inference]

negative regulation of amino acid transport [inference]

negative regulation of gamma-aminobutyric acid secretion

negative regulation of monoatomic ion transport [inference]

negative regulation of serotonin secretion

negative regulation of secretion [inference]

negative regulation of gamma-aminobutyric acid secretion

negative regulation of secretion by cell [inference]

negative regulation of serotonin secretion

negative regulation of amine transport [inference]

negative regulation of amino acid transport [inference]

negative regulation of gamma-aminobutyric acid secretion

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

adenylate cyclase-inhibiting serotonin receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway [inference]

phospholipase C-activating serotonin receptor signaling pathway

G protein-coupled serotonin receptor signaling pathway [inference]

regulation of cell communication [inference]

negative regulation of cell communication [inference]

negative regulation of synaptic transmission [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic transmission, GABAergic [inference]

negative regulation of synaptic transmission, GABAergic

regulation of neurotransmitter secretion [inference]

regulation of synaptic vesicle exocytosis

negative regulation of synaptic transmission [inference]

regulation of synaptic transmission, glutamatergic [inference]

negative regulation of synaptic transmission, glutamatergic

presynaptic modulation of chemical synaptic transmission

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of smooth muscle cell proliferation [inference]

positive regulation of vascular associated smooth muscle cell proliferation

regulation of smooth muscle cell proliferation [inference]

positive regulation of smooth muscle cell proliferation [inference]

positive regulation of vascular associated smooth muscle cell proliferation

regulation of vascular associated smooth muscle cell proliferation [inference]

positive regulation of vascular associated smooth muscle cell proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of smooth muscle cell proliferation [inference]

positive regulation of vascular associated smooth muscle cell proliferation

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of synaptic transmission [inference]

negative regulation of secretion by cell [inference]

negative regulation of serotonin secretion

regulation of vesicle-mediated transport [inference]

regulation of exocytosis [inference]

regulation of regulated secretory pathway [inference]

regulation of synaptic vesicle exocytosis

regulation of secretion by cell [inference]

regulation of serotonin secretion [inference]

negative regulation of serotonin secretion

regulation of exocytosis [inference]

regulation of regulated secretory pathway [inference]

regulation of synaptic vesicle exocytosis

regulation of neurotransmitter secretion [inference]

regulation of synaptic vesicle exocytosis

regulation of catecholamine secretion [inference]

regulation of dopamine secretion

negative regulation of secretion by cell [inference]

negative regulation of serotonin secretion

regulation of multicellular organismal process [inference]

regulation of behavior

regulation of biological quality [inference]

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

vasoconstriction

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
cytoplasm	IDA	17325130
endoplasmic reticulum	ISO
endoplasmic reticulum	IEA
plasma membrane	ISS
plasma membrane	ISO

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex [inference]

G protein-coupled serotonin receptor complex

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

presynaptic membrane

cell junction [inference]

synapse [inference]

serotonergic synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

neuron projection terminus [inference]

axon terminus [inference]

calyx of Held

presynapse [inference]

axon terminus [inference]

calyx of Held

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
Gi/o-coupled serotonin receptor activity	IEA
G protein-coupled serotonin receptor activity	ISO
G protein-coupled serotonin receptor activity	IDA	17325130
G protein-coupled serotonin receptor activity	IBA
neurotransmitter receptor activity	IBA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated calcium channel activity [inference]

voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels [inference]

voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels

monoatomic cation channel activity [inference]

calcium channel activity [inference]

voltage-gated calcium channel activity [inference]

voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels [inference]

voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels

voltage-gated monoatomic cation channel activity [inference]

voltage-gated calcium channel activity [inference]

voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels [inference]

voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

calcium channel activity [inference]

voltage-gated calcium channel activity [inference]

voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels [inference]

voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels

voltage-gated monoatomic cation channel activity [inference]

voltage-gated calcium channel activity [inference]

voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels [inference]

voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels

metal ion transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity [inference]

calcium channel activity [inference]

voltage-gated calcium channel activity [inference]

voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels [inference]

voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity [inference]

calcium channel activity [inference]

voltage-gated calcium channel activity [inference]

voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels [inference]

voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated calcium channel activity [inference]

voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels [inference]

voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels

monoatomic cation channel activity [inference]

calcium channel activity [inference]

voltage-gated calcium channel activity [inference]

voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels [inference]

voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels

voltage-gated monoatomic cation channel activity [inference]

voltage-gated calcium channel activity [inference]

voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels [inference]

voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels

gated channel activity [inference]

voltage-gated channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated calcium channel activity [inference]

voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels [inference]

voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels

salt transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity [inference]

calcium channel activity [inference]

voltage-gated calcium channel activity [inference]

voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels [inference]

voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels

binding [inference]

small molecule binding [inference]

heterocyclic compound binding

ion binding [inference]

cation binding [inference]

serotonin binding

amine binding [inference]

serotonin binding

organic cyclic compound binding [inference]

serotonin binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

G protein-coupled amine receptor activity [inference]

G protein-coupled serotonin receptor activity

Gi/o-coupled serotonin receptor activity

serotonin receptor activity

neurotransmitter receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

5-hydroxytryptamine receptor 1B

Functional Category

D: Cell cycle control, cell division, chromosome partitioning
J: Translation, ribosomal structure and biogenesis
X: Mobilome: prophages, transposons

Displaying **all 7** entries
Gene Ontology
adenylate cyclase-activating adrenergic receptor signaling pathway
adenylate cyclase-inhibiting serotonin receptor signaling pathway
bone remodeling
cellular response to alkaloid
chemical synaptic transmission
negative regulation of serotonin secretion
regulation of behavior

Displaying **all 4** entries
InterPro
5-Hydroxytryptamine 1B receptor
5-hydroxytryptamine receptor family
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Ortholog

Displaying entries **41 - 50** of **125** in total

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Species	Gene ID	Orthologous MAtrix
Ovis aries	101111375	SHEEP18561
Gorilla gorilla gorilla	101124222	GORGO36008
Oryzias latipes	101172866	ORYLA11807
Jaculus jaculus	101601333	JACJA12049
Mustela putorius furo	101671629	MUSPF13438
Heterocephalus glaber	101697435	HETGA13198
Ficedula albicollis	101817797	FICAL05478
Melopsittacus undulatus	101877416	MELUD01978
Chrysemys picta bellii	101947872	CHRPI34645
Ictidomys tridecemlineatus	101958165	ICTTR14903

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Acknowledgements