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cytochrome P450 family 19 subfamily A member 1

Summary

Gene Symbol

CYP19A1

Aliases

ARO
ARO1
CPV1
CYAR
P-450AROM
aromatase

Organism

Homo sapiens (human)

External Links

NCBI Gene

1588

HGNC

2594

KEGG Gene ID

hsa:1588

PubChem

1588

Alliance of Genome Resources

HGNC:2594

Annotation

Keyword

3D-structure
Alternative splicing
Direct protein sequencing
Disease variant
Heme
Lipid metabolism
Microsome
Monooxygenase
Pseudohermaphroditism
Reference proteome
Transmembrane helix

Proteins

Displaying **all 5** entries
UniProt	Protein Name
A8K6W3	CYPXIX Cytochrome P-450AROM Cytochrome P450 19A1 Estrogen synthase
Q8IYG4	CYPXIX Cytochrome P-450AROM Cytochrome P450 19A1 Estrogen synthase
P11511	CYPXIX Cytochrome P-450AROM Cytochrome P450 19A1 Estrogen synthase
Q8TCA4
Q05CU4	CYPXIX Cytochrome P450 19A1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
mammary gland development	IEA
estrogen biosynthetic process
female gonad development	IBA
uterus development	IEA
female genitalia development	IEA

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

hormone catabolic process [inference]

androgen catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

steroid catabolic process [inference]

androgen catabolic process

organic cyclic compound catabolic process [inference]

steroid catabolic process [inference]

androgen catabolic process

biosynthetic process [inference]

hormone biosynthetic process [inference]

estrogen biosynthetic process

cellular biosynthetic process [inference]

ketone biosynthetic process [inference]

testosterone biosynthetic process

small molecule biosynthetic process [inference]

ketone biosynthetic process [inference]

testosterone biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process

testosterone biosynthetic process

steroid hormone biosynthetic process [inference]

estrogen biosynthetic process

ketone biosynthetic process [inference]

testosterone biosynthetic process

olefinic compound biosynthetic process [inference]

testosterone biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process

testosterone biosynthetic process

steroid hormone biosynthetic process [inference]

estrogen biosynthetic process

organic hydroxy compound biosynthetic process [inference]

testosterone biosynthetic process

hormone metabolic process [inference]

androgen metabolic process [inference]

androgen catabolic process

estrogen metabolic process [inference]

estrogen biosynthetic process

hormone biosynthetic process [inference]

estrogen biosynthetic process

hormone catabolic process [inference]

androgen catabolic process

cellular metabolic process [inference]

cellular ketone metabolic process [inference]

ketone biosynthetic process [inference]

testosterone biosynthetic process

cellular biosynthetic process [inference]

ketone biosynthetic process [inference]

testosterone biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process

testosterone biosynthetic process

steroid hormone biosynthetic process [inference]

estrogen biosynthetic process

steroid catabolic process [inference]

androgen catabolic process

androgen metabolic process [inference]

androgen catabolic process

estrogen metabolic process [inference]

estrogen biosynthetic process

sterol metabolic process

lipid biosynthetic process [inference]

steroid biosynthetic process

testosterone biosynthetic process

steroid hormone biosynthetic process [inference]

estrogen biosynthetic process

lipid catabolic process [inference]

steroid catabolic process [inference]

androgen catabolic process

small molecule metabolic process [inference]

cellular ketone metabolic process [inference]

ketone biosynthetic process [inference]

testosterone biosynthetic process

small molecule biosynthetic process [inference]

ketone biosynthetic process [inference]

testosterone biosynthetic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process

testosterone biosynthetic process

steroid hormone biosynthetic process [inference]

estrogen biosynthetic process

steroid catabolic process [inference]

androgen catabolic process

androgen metabolic process [inference]

androgen catabolic process

estrogen metabolic process [inference]

estrogen biosynthetic process

sterol metabolic process

lipid biosynthetic process [inference]

steroid biosynthetic process

testosterone biosynthetic process

steroid hormone biosynthetic process [inference]

estrogen biosynthetic process

lipid catabolic process [inference]

steroid catabolic process [inference]

androgen catabolic process

cellular ketone metabolic process [inference]

ketone biosynthetic process [inference]

testosterone biosynthetic process

olefinic compound metabolic process [inference]

olefinic compound biosynthetic process [inference]

testosterone biosynthetic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process

testosterone biosynthetic process

steroid hormone biosynthetic process [inference]

estrogen biosynthetic process

steroid catabolic process [inference]

androgen catabolic process

androgen metabolic process [inference]

androgen catabolic process

estrogen metabolic process [inference]

estrogen biosynthetic process

sterol metabolic process

organic cyclic compound catabolic process [inference]

steroid catabolic process [inference]

androgen catabolic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process

testosterone biosynthetic process

steroid hormone biosynthetic process [inference]

estrogen biosynthetic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

steroid catabolic process [inference]

androgen catabolic process

organic cyclic compound catabolic process [inference]

steroid catabolic process [inference]

androgen catabolic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process

testosterone biosynthetic process

steroid hormone biosynthetic process [inference]

estrogen biosynthetic process

ketone biosynthetic process [inference]

testosterone biosynthetic process

olefinic compound biosynthetic process [inference]

testosterone biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process

testosterone biosynthetic process

steroid hormone biosynthetic process [inference]

estrogen biosynthetic process

organic hydroxy compound biosynthetic process [inference]

testosterone biosynthetic process

organic hydroxy compound metabolic process [inference]

sterol metabolic process

organic hydroxy compound biosynthetic process [inference]

testosterone biosynthetic process

cellular process [inference]

syncytium formation

cellular metabolic process [inference]

cellular ketone metabolic process [inference]

ketone biosynthetic process [inference]

testosterone biosynthetic process

cellular biosynthetic process [inference]

ketone biosynthetic process [inference]

testosterone biosynthetic process

reproductive process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

gonad development [inference]

female gonad development

genitalia development [inference]

female genitalia development

uterus development

prostate gland growth

multicellular organismal process [inference]

organ growth [inference]

prostate gland growth

developmental process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

gonad development [inference]

female gonad development

genitalia development [inference]

female genitalia development

uterus development

prostate gland growth

anatomical structure formation involved in morphogenesis [inference]

syncytium formation

anatomical structure development [inference]

animal organ development [inference]

gonad development [inference]

female gonad development

gland development [inference]

mammary gland development

genitalia development [inference]

female genitalia development

uterus development

reproductive structure development [inference]

gonad development [inference]

female gonad development

genitalia development [inference]

female genitalia development

uterus development

growth [inference]

developmental growth [inference]

organ growth [inference]

prostate gland growth

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to organic cyclic compound [inference]

response to estradiol

response to lipid [inference]

response to estradiol

response to oxygen-containing compound [inference]

response to estradiol

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

negative regulation of macrophage migration [inference]

negative regulation of macrophage chemotaxis

regulation of leukocyte migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

negative regulation of macrophage migration [inference]

negative regulation of macrophage chemotaxis

regulation of leukocyte chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

regulation of macrophage chemotaxis [inference]

negative regulation of macrophage chemotaxis

regulation of macrophage migration [inference]

regulation of macrophage chemotaxis [inference]

negative regulation of macrophage chemotaxis

negative regulation of macrophage migration [inference]

negative regulation of macrophage chemotaxis

regulation of signaling [inference]

positive regulation of signaling [inference]

positive regulation of hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

regulation of steroid hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

regulation of estradiol secretion [inference]

positive regulation of estradiol secretion

regulation of localization [inference]

regulation of transport [inference]

regulation of lipid transport [inference]

positive regulation of lipid transport [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

regulation of steroid hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

regulation of estradiol secretion [inference]

positive regulation of estradiol secretion

regulation of secretion [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

regulation of steroid hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

regulation of estradiol secretion [inference]

positive regulation of estradiol secretion

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

positive regulation of transport [inference]

positive regulation of lipid transport [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

regulation of lipid localization [inference]

regulation of lipid transport [inference]

positive regulation of lipid transport [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

regulation of steroid hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

regulation of estradiol secretion [inference]

positive regulation of estradiol secretion

positive regulation of lipid localization [inference]

positive regulation of lipid transport [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

regulation of locomotion [inference]

negative regulation of locomotion [inference]

negative regulation of chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

negative regulation of macrophage migration [inference]

negative regulation of macrophage chemotaxis

regulation of chemotaxis [inference]

regulation of leukocyte chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

regulation of macrophage chemotaxis [inference]

negative regulation of macrophage chemotaxis

negative regulation of chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

negative regulation of macrophage migration [inference]

negative regulation of macrophage chemotaxis

regulation of leukocyte chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

regulation of macrophage chemotaxis [inference]

negative regulation of macrophage chemotaxis

regulation of macrophage migration [inference]

regulation of macrophage chemotaxis [inference]

negative regulation of macrophage chemotaxis

negative regulation of macrophage migration [inference]

negative regulation of macrophage chemotaxis

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

negative regulation of macrophage migration [inference]

negative regulation of macrophage chemotaxis

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

negative regulation of macrophage migration [inference]

negative regulation of macrophage chemotaxis

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

positive regulation of transport [inference]

positive regulation of lipid transport [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

positive regulation of multicellular organismal process [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

positive regulation of lipid localization [inference]

positive regulation of lipid transport [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

negative regulation of macrophage migration [inference]

negative regulation of macrophage chemotaxis

negative regulation of locomotion [inference]

negative regulation of chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

negative regulation of macrophage migration [inference]

negative regulation of macrophage chemotaxis

negative regulation of cellular process [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

negative regulation of macrophage migration [inference]

negative regulation of macrophage chemotaxis

negative regulation of response to stimulus [inference]

negative regulation of defense response [inference]

negative regulation of inflammatory response [inference]

negative regulation of chronic inflammatory response

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response [inference]

negative regulation of chronic inflammatory response

negative regulation of chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response [inference]

negative regulation of chronic inflammatory response

negative regulation of chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

regulation of inflammatory response [inference]

regulation of chronic inflammatory response [inference]

negative regulation of chronic inflammatory response

negative regulation of inflammatory response [inference]

negative regulation of chronic inflammatory response

regulation of chemotaxis [inference]

regulation of leukocyte chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

regulation of macrophage chemotaxis [inference]

negative regulation of macrophage chemotaxis

negative regulation of chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

negative regulation of response to stimulus [inference]

negative regulation of defense response [inference]

negative regulation of inflammatory response [inference]

negative regulation of chronic inflammatory response

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response [inference]

negative regulation of chronic inflammatory response

negative regulation of chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

regulation of response to stress [inference]

regulation of defense response [inference]

negative regulation of defense response [inference]

negative regulation of inflammatory response [inference]

negative regulation of chronic inflammatory response

regulation of inflammatory response [inference]

regulation of chronic inflammatory response [inference]

negative regulation of chronic inflammatory response

negative regulation of inflammatory response [inference]

negative regulation of chronic inflammatory response

regulation of cellular process [inference]

regulation of cell communication [inference]

positive regulation of cell communication [inference]

positive regulation of hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

regulation of steroid hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

regulation of estradiol secretion [inference]

positive regulation of estradiol secretion

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

negative regulation of cellular process [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

negative regulation of macrophage migration [inference]

negative regulation of macrophage chemotaxis

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

regulation of steroid hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

regulation of estradiol secretion [inference]

positive regulation of estradiol secretion

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

negative regulation of macrophage migration [inference]

negative regulation of macrophage chemotaxis

regulation of leukocyte chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

regulation of macrophage chemotaxis [inference]

negative regulation of macrophage chemotaxis

regulation of macrophage migration [inference]

regulation of macrophage chemotaxis [inference]

negative regulation of macrophage chemotaxis

negative regulation of macrophage migration [inference]

negative regulation of macrophage chemotaxis

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

negative regulation of macrophage migration [inference]

negative regulation of macrophage chemotaxis

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

negative regulation of macrophage migration [inference]

negative regulation of macrophage chemotaxis

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of endocrine process [inference]

regulation of steroid hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

regulation of estradiol secretion [inference]

positive regulation of estradiol secretion

positive regulation of multicellular organismal process [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

androgen metabolic process [inference]

androgen catabolic process

estrogen metabolic process [inference]

estrogen biosynthetic process

hormone biosynthetic process [inference]

estrogen biosynthetic process

hormone catabolic process [inference]

androgen catabolic process

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

regulation of steroid hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

regulation of estradiol secretion [inference]

positive regulation of estradiol secretion

Displaying **all 3** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	IBA IDA
endoplasmic reticulum membrane
membrane		2848247

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
electron transfer activity		2848247
steroid hydroxylase activity
oxygen binding		2848247
iron ion binding	IEA
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen		1371509