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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
insulin receptor
Summary
- Gene Symbol
-
- Insr
- Organism
- Mus musculus (house mouse)
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Cell membrane
- Cleavage on pair of basic residues
- Disulfide bond
- Endosome
- Glycoprotein
- Lysosome
- Phosphoprotein
- Receptor
- Reference proteome
- Repeat
- S-nitrosylation
- Signal
- Transmembrane helix
- Tyrosine-protein kinase
- Proteins
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| positive regulation of cell population proliferation | ||
| negative regulation of protein phosphorylation | ||
| amyloid-beta clearance | ||
| positive regulation of protein-containing complex disassembly | ||
| positive regulation of developmental growth |
GO Hierarchy
- positive regulation of respiratory burst
- positive regulation of respiratory burst
biological process
metabolic process [inference]
cellular process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
positive regulation of biosynthetic process [inference]
positive regulation of macromolecule metabolic process [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of nitrogen compound metabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of phosphorus metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
positive regulation of nitrogen compound metabolic process [inference]
regulation of protein metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of small molecule metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of signaling [inference]
regulation of localization [inference]
positive regulation of biological process [inference]
positive regulation of metabolic process [inference]
positive regulation of biosynthetic process [inference]
positive regulation of macromolecule metabolic process [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of nitrogen compound metabolic process [inference]
positive regulation of cellular process [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of phosphorus metabolic process [inference]
positive regulation of cellular process [inference]
regulation of cellular component organization [inference]
regulation of molecular function [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| external side of plasma membrane | ||
| membrane | ||
| late endosome | ||
| receptor complex | ||
| neuronal cell body membrane |
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| insulin-like growth factor I binding | ||
| lipoic acid binding | ||
| insulin-like growth factor receptor binding | ||
| insulin receptor substrate binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Rodentia
- Group Name
- insulin receptor
- Functional Category
-
- I: Lipid transport and metabolism
- Q: Secondary metabolites biosynthesis, transport and catabolism
- T: Signal transduction mechanisms
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050470 | Donohue syndrome | |
| DOID:0050741 | alcohol dependence | |
| DOID:0060071 | pre-malignant neoplasm | |
| DOID:0070220 | familial hyperinsulinemic hypoglycemia 5 | |
| DOID:0080208 | metabolic dysfunction-associated steatotic liver disease | |
| DOID:10605 | short bowel syndrome | |
| DOID:10652 | Alzheimer's disease | |
| DOID:11714 | gestational diabetes | |
| DOID:13413 | hepatic encephalopathy | |
| DOID:14330 | Parkinson's disease |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 3643 | HGNC:6091 | HUMAN40215 | ||
| 24954 | 10116_1:003de9 | RGD:2917 | RATNO05588 | |
| 42549 | FB:FBgn0283499 | |||
| 175410 | WB:WBGene00000898 | |||
| 245699 | ZFIN:ZDB-GENE-020503-3 | DANRE29770 | ||
| 245700 | ZFIN:ZDB-GENE-020503-4 | DANRE22677 | ||
| 396755 | PIGXX18653 | |||
| 443431 | SHEEP16313 | |||
| 455649 | PANTR16965 | |||
| 484990 | CANLF07902 |
