GlyCosmos Portal

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Insulin receptor

Summary

UniProt ID

P15208

Gene Symbol

Insr

Organism

Mus musculus (house mouse)

External Links

GlycoProtDB

GPDB0003397

GlyConnect

2393

GlyGen

P15208

PubChem

P15208

The O-GlcNAc Database

P15208

Annotation

Keyword

3D-structure
ATP-binding
Cell membrane
Cleavage on pair of basic residues
Disulfide bond
Endosome
Glycoprotein
Lysosome
Phosphoprotein
Receptor
Reference proteome
Repeat
S-nitrosylation
Signal
Transmembrane helix
Tyrosine-protein kinase

Gene Ontology (GO)

Displaying entries **1 - 10** of 44 in total

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GO Term
negative regulation of protein phosphorylation
positive regulation of protein phosphorylation
heart morphogenesis
receptor-mediated endocytosis
positive regulation of glycolytic process
positive regulation of DNA-templated transcription
positive regulation of glucose import
negative regulation of feeding behavior
positive regulation of receptor internalization
receptor internalization

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GO Term
nuclear envelope
lysosome
plasma membrane
insulin receptor complex
membrane
axon
nuclear lumen
dendrite membrane
neuronal cell body
receptor complex

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GO Term
cargo receptor activity
insulin binding
protein-containing complex binding
protein kinase binding
PTB domain binding
protein domain specific binding
lipoic acid binding
insulin-like growth factor I binding
insulin-like growth factor II binding
3-phosphoinositide-dependent protein kinase binding

Annotation information from UniProt.

Sequence

MGFGRGCETTAVPLLVAVAALLVGTAGHLYPGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNEECGDVCPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHKECLGNCSEPDDPTKCVACRNFYLDGQCVETCPPPYYHFQDWRCVNFSFCQDLHFKCRNSRKPGCHQYVIHNNKCIPECPSGYTMNSSNLMCTPCLGPCPKVCQILEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGFLKIRRSYALVSLSFFRKLHLIRGETLEIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCENELLKFSFIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVDIDPPQRSNDPKSQTPSHPGWLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVYWERQAEDSELFELDYCLKGLKLPSRTWSPPFESDDSQKHNQSEYDDSASECCSCPKTDSQILKELEESSFRKTFEDYLHNVVFVPRPSRKRRSLEEVGNVTATTLTLPDFPNVSSTIVPTSQEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDSPDERCSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCRLRGLSPGNYSVRVRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGPMGPLYASSNPEYLSASDVFPSSVYVPDEWEVPREKITLLRELGQGSFGMVYEGNAKDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSHLRSLRPDAENNPGRPPPTLQEMIQMTAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTASSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDPPDNCPERLTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFYSEENKAPESEELEMEFEDMENVPLDRSSHCQREEAGGREGGSSLSIKRTYDEHIPYTHMNGGKKNGRVLTLPRSNPS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

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Position	Description	PubMed ID	GlyTouCan ID	Source
43	N-linked (GlcNAc...) asparagine			UniProt GlyGen
52	N-linked (GlcNAc...) asparagine		G07755XJ	UniProt GlyGen
105	N-linked (GlcNAc...) asparagine		G41247ZX	UniProt GlyGen
138	N-linked (GlcNAc...) asparagine		G80920RR	GlycoProtDB UniProt GlyGen
242	N-linked (GlcNAc...) asparagine		G29545VG G05724UK G39188ZX	GlycoProtDB UniProt GlyGen GlyConnect
282	N-linked (GlcNAc...) asparagine		G80920RR	GlycoProtDB UniProt GlyGen
322	N-linked (GlcNAc...) asparagine			UniProt GlyGen
364	N-linked (GlcNAc...) asparagine		G02815KT	GlycoProtDB UniProt GlyGen
424	N-linked (GlcNAc...) asparagine		G06110VR	GlycoProtDB UniProt GlyGen GlyConnect
445	N-linked (GlcNAc...) asparagine	19349973 19656770	G19973ZD G70101JE G64527OM G06110VR	GlycoProtDB UniProt GlyGen GlyConnect

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 6** entries
Pathway Name	Organism
IRS activation	Mus musculus
Insulin receptor recycling	Mus musculus
Insulin receptor signalling cascade	Mus musculus
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Mus musculus
Signal attenuation	Mus musculus
Signaling by Insulin receptor	Mus musculus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

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External Links

Annotation

International Collaboration

Acknowledgements