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MIRAGE
inositol 1,4,5-trisphosphate receptor 1
Summary
- Gene Symbol
-
- Itpr1
- Organism
- Mus musculus (house mouse)
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Alternative splicing
- Apoptosis
- Calcium channel
- Cytoplasm
- Cytoplasmic vesicle
- Direct protein sequencing
- Disulfide bond
- Endoplasmic reticulum
- Isopeptide bond
- Ligand-gated ion channel
- Membrane
- Metal-binding
- Palmitate
- Phosphoprotein
- Receptor
- Reference proteome
- Repeat
- Transmembrane helix
- Ubl conjugation
- Zinc
- Proteins
| UniProt | Protein Name |
|---|---|
| Q8BQN0 |
|
| P11881 |
|
| Q3UVA1 |
|
| Q8C7X9 |
|
| Q8C8N0 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| ion channel modulating, G protein-coupled receptor signaling pathway | ||
| release of sequestered calcium ion into cytosol by endoplasmic reticulum | ||
| positive regulation of calcium ion transport | ||
| response to hypoxia | ||
| phospholipase C-activating G protein-coupled receptor signaling pathway |
GO Hierarchy
biological process
cellular process [inference]
response to stimulus [inference]
localization [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of localization [inference]
positive regulation of biological process [inference]
regulation of cellular process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| dendrite | ||
| transport vesicle membrane | ||
| GABA-ergic synapse | ||
| nuclear envelope | ||
| cytoplasm |
| GO Term | Evidence Code | PMID |
|---|---|---|
| phosphatidylinositol binding | ||
| ion channel activity |
|
|
| identical protein binding | ||
| inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity | ||
| protein-containing complex binding |
GO Hierarchy
molecular function
OrthoDB (Group)
- Group level
- Rodentia
- Group Name
- Inositol 1,4,5-trisphosphate receptor
- Functional Category
-
- C: Energy production and conversion
- E: Amino acid transport and metabolism
- I: Lipid transport and metabolism
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050965 | spinocerebellar ataxia type 15 | |
| DOID:0050978 | spinocerebellar ataxia type 29 | |
| DOID:0060319 | cardiac arrest | |
| DOID:0111578 | Gillespie syndrome | |
| DOID:10591 | pre-eclampsia | |
| DOID:10652 | Alzheimer's disease | |
| DOID:11714 | gestational diabetes | |
| DOID:12858 | Huntington's disease | |
| DOID:1441 | autosomal dominant cerebellar ataxia | |
| DOID:1682 | congenital heart disease |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 3708 | HGNC:6180 | HUMAN68200 | ||
| 25262 | 10116_1:001bbb | RGD:2933 | RATNO32094 | |
| 40664 | FB:FBgn0010051 | |||
| 177546 | WB:WBGene00002173 | |||
| 317697 | BOVIN17442 | |||
| 397454 | PIGXX04492 | |||
| 460134 | PANTR30309 | |||
| 476548 | CANLF07320 | |||
| 567611 | ZFIN:ZDB-GENE-070604-3 | |||
| 703669 | MACMU28156 |
