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crumbs family member 1, photoreceptor morphogenesis associated

Summary

Gene Symbol

Crb1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

170788

PubChem

170788

Alliance of Genome Resources

MGI:2136343

Annotation

Keyword

Alternative splicing
Calcium
Cell junction
Cell membrane
Cell projection
Cytoplasm
Developmental protein
Differentiation
Disulfide bond
EGF-like domain
Glycoprotein
Neurogenesis
Reference proteome
Repeat
Secreted
Signal
Transmembrane helix

Proteins

Displaying **all 4** entries
UniProt	Protein Name
Q7TSG9
Q8VHS2
A0A7D6VMF7
A0A7D6VRP0

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	PMID
blood vessel remodeling	IMP	25147295
plasma membrane organization	IMP	15316081
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IBA
visual perception	IMP	12915475 15316081
protein localization	IMP	16885194

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular process [inference]

cell adhesion [inference]

cell-cell adhesion [inference]

cell-cell adhesion via plasma-membrane adhesion molecules [inference]

heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules

establishment or maintenance of cell polarity [inference]

establishment of cell polarity [inference]

establishment of bipolar cell polarity [inference]

establishment of bipolar cell polarity involved in cell morphogenesis

establishment or maintenance of bipolar cell polarity [inference]

establishment or maintenance of apical/basal cell polarity [inference]

establishment or maintenance of epithelial cell apical/basal polarity

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular developmental process [inference]

cell differentiation [inference]

glial cell differentiation

cell development [inference]

neuron development [inference]

photoreceptor cell development [inference]

eye photoreceptor cell development

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization

cellular response to stimulus [inference]

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus

cellular component organization or biogenesis [inference]

cellular component organization [inference]

photoreceptor cell outer segment organization

membrane organization

plasma membrane organization

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of light stimulus [inference]

visual perception

photoreceptor cell maintenance

tissue remodeling [inference]

blood vessel remodeling

developmental process [inference]

anatomical structure morphogenesis [inference]

post-embryonic animal morphogenesis [inference]

post-embryonic retina morphogenesis in camera-type eye

retina morphogenesis in camera-type eye

anatomical structure formation involved in morphogenesis [inference]

retina layer formation

anatomical structure development [inference]

cell development [inference]

neuron development [inference]

photoreceptor cell development [inference]

eye photoreceptor cell development

retina development in camera-type eye

cellular developmental process [inference]

cell differentiation [inference]

glial cell differentiation

cell development [inference]

neuron development [inference]

photoreceptor cell development [inference]

eye photoreceptor cell development

response to stimulus [inference]

response to external stimulus [inference]

detection of external stimulus [inference]

detection of light stimulus [inference]

detection of visible light [inference]

detection of light stimulus involved in visual perception

detection of light stimulus involved in sensory perception [inference]

detection of light stimulus involved in visual perception

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus [inference]

detection of light stimulus [inference]

detection of visible light [inference]

detection of light stimulus involved in visual perception

detection of light stimulus involved in sensory perception [inference]

detection of light stimulus involved in visual perception

cellular response to light stimulus

cellular response to radiation [inference]

cellular response to light stimulus

detection of abiotic stimulus [inference]

detection of light stimulus [inference]

detection of visible light [inference]

detection of light stimulus involved in visual perception

detection of light stimulus involved in sensory perception [inference]

detection of light stimulus involved in visual perception

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus

detection of stimulus [inference]

detection of external stimulus [inference]

detection of light stimulus [inference]

detection of visible light [inference]

detection of light stimulus involved in visual perception

detection of light stimulus involved in sensory perception [inference]

detection of light stimulus involved in visual perception

detection of abiotic stimulus [inference]

detection of light stimulus [inference]

detection of visible light [inference]

detection of light stimulus involved in visual perception

detection of light stimulus involved in sensory perception [inference]

detection of light stimulus involved in visual perception

detection of stimulus involved in sensory perception [inference]

detection of light stimulus involved in sensory perception [inference]

detection of light stimulus involved in visual perception

cellular response to stimulus [inference]

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
photoreceptor outer segment	IDA	15316081
photoreceptor inner segment	ISO
photoreceptor inner segment	IEA
extracellular region	IEA
cytoplasm	IEA

GO Hierarchy

cellular component

protein-containing complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

subapical complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

apical plasma membrane

cell junction [inference]

anchoring junction [inference]

cell-cell junction

cell-substrate junction [inference]

focal adhesion

cell projection [inference]

plasma membrane bounded cell projection [inference]

glial cell projection

actin-based cell projection [inference]

microvillus

apical part of cell

Displaying **all 2** entries
GO Term	Evidence Code	PMID
calcium ion binding	IEA
protein binding	IPI	15316081

GO Hierarchy

molecular function

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

crumbs

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
calcium ion binding

Displaying **all 8** entries
InterPro
Concanavalin A-like lectin/glucanase domain superfamily
EGF-like calcium-binding domain
EGF-like calcium-binding, conserved site
EGF-like domain
EGF-like, conserved site
EGF-type aspartate/asparagine hydroxylation site
Growth factor receptor cysteine-rich domain superfamily
Laminin G domain