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antigen identified by monoclonal antibody Ki 67

Summary

Gene Symbol

Mki67

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

17345

PubChem

17345

Alliance of Genome Resources

MGI:106035

Annotation

Keyword

ATP-binding
Acetylation
Alternative splicing
Cell cycle
Chromosome
DNA-binding
Isopeptide bond
Nucleus
Phosphoprotein
Reference proteome
Repeat
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
E9PVX6	Antigen identified by monoclonal antibody Ki-67 homolog

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
regulation of chromosome segregation	IBA ISO ISS
cell population proliferation	IDA IMP	12972605 26949251
regulation of chromatin organization	IMP	26949251
epithelial cell proliferation	IDA	19303854 33129760
cholangiocyte proliferation	IDA	25446530

GO Hierarchy

biological process

cellular process [inference]

cell cycle [inference]

meiotic cell cycle

cell population proliferation

epithelial cell proliferation

epithelial cell proliferation involved in liver morphogenesis [inference]

hepatocyte proliferation

cholangiocyte proliferation

stem cell proliferation

reproductive process [inference]

meiotic cell cycle

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

regulation of nuclear division [inference]

regulation of mitotic nuclear division

regulation of chromatin organization

regulation of cell cycle [inference]

regulation of mitotic cell cycle [inference]

regulation of mitotic nuclear division

regulation of cell cycle process [inference]

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GO Term	Evidence Code	PMID
condensed chromosome	IDA ISO	12355204
nucleoplasm	ISO
nuclear body	ISO
nucleus	IBA IDA ISO	12368262 15237214 16314515 17257418 18604197 19409883 21464233 22984613 23284756 23786676 24191021 24582971 25433207 28811219
cytoplasm	IDA	11731231

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

chromosome

condensed chromosome

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

chromosome

condensed chromosome

nucleolus

chromosomal region [inference]

chromosome, centromeric region

Displaying **all 2** entries
GO Term	Evidence Code	PMID
DNA binding	IEA
ATP binding	IEA

GO Hierarchy

molecular function

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

proliferation marker protein Ki-67

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
regulation of chromosome segregation
regulation of mitotic nuclear division

Disease

Disease Ontology

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DO ID	Disease Name	Source
DOID:0050745	diffuse large B-cell lymphoma	Alliance of Genome Resources
DOID:0080178	mucositis	Alliance of Genome Resources
DOID:0081267	graft-versus-host disease	Alliance of Genome Resources
DOID:10286	prostate carcinoma	Alliance of Genome Resources
DOID:10534	stomach cancer	Alliance of Genome Resources
DOID:11054	urinary bladder cancer	Alliance of Genome Resources
DOID:1227	neutropenia	Alliance of Genome Resources
DOID:127	leiomyoma	Alliance of Genome Resources
DOID:1324	lung cancer	Alliance of Genome Resources
DOID:13949	interstitial cystitis	Alliance of Genome Resources

Ortholog

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	4288		HGNC:7107	HUMAN03390
Rattus norvegicus	291234	10116_1:000641	RGD:1305476	RATNO16345
Pan troglodytes	450866			PANTR01802
Bos taurus	513220			BOVIN21758
Danio rerio	564521		ZFIN:ZDB-GENE-030131-9771
Macaca mulatta	697883			MACMU45795
Xenopus tropicalis	779458		Xenbase:XB-GENE-6457930
Callithrix jacchus	100411224			CALJA08083
Pongo abelii	100433559			PONAB02084
Nomascus leucogenys	100586199			NOMLE26855

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Annotation

OrthoDB (Group)

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Acknowledgements