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Tyrosine-protein kinase receptor cam-1

Summary

Gene Symbol

cam-1

Organism

Caenorhabditis elegans

External Links

NCBI Gene

174473

PubChem

174473

Alliance of Genome Resources

WB:WBGene00000289

Annotation

Keyword

ATP-binding
Alternative splicing
Cell membrane
Cell projection
Disulfide bond
Glycoprotein
Immunoglobulin domain
Kringle
Magnesium
Metal-binding
Neurogenesis
Phosphoprotein
Receptor
Reference proteome
Synapse
Transmembrane helix
Tyrosine-protein kinase
Wnt signaling pathway

Proteins

Displaying 1 entry
UniProt	Protein Name
G5EGK5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
establishment of neuroblast polarity	IMP	10476968
positive regulation of neuron projection development	IBA
anatomical structure morphogenesis	IEA
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA
neuron migration	IMP	18622031

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular process [inference]

establishment or maintenance of cell polarity [inference]

establishment of cell polarity [inference]

establishment of neuroblast polarity

establishment or maintenance of neuroblast polarity [inference]

establishment of neuroblast polarity

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

cell motility [inference]

cell migration

neuron migration

neuroblast migration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance

multicellular organismal process [inference]

multicellular organism development

developmental process [inference]

anatomical structure morphogenesis

anatomical structure development [inference]

multicellular organism development

system development [inference]

nervous system development

response to stimulus [inference]

response to endogenous stimulus [inference]

response to growth factor [inference]

cellular response to growth factor stimulus [inference]

cellular response to nerve growth factor stimulus

response to nerve growth factor [inference]

cellular response to nerve growth factor stimulus

cellular response to endogenous stimulus [inference]

cellular response to growth factor stimulus [inference]

cellular response to nerve growth factor stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of intracellular signal transduction [inference]

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of intracellular signal transduction [inference]

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of intracellular signal transduction [inference]

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

positive regulation of neuron projection development

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

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GO Term	Evidence Code	PMID
perikaryon	IEA
receptor complex	IBA
neuronal cell body membrane	IDA	15944127
plasma membrane	IBA IDA IEA	10476968 17942487
neuromuscular junction	IDA	15944127

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

cell junction [inference]

synapse

neuromuscular junction

cell projection

plasma membrane bounded cell projection [inference]

neuron projection

perikaryon

cell body membrane [inference]

neuronal cell body membrane

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GO Term	Evidence Code	PMID
protein binding	IPI	20711352
frizzled binding	IPI	22464329
metal ion binding	IEA
transmembrane receptor protein tyrosine kinase activity	IBA IDA IEA	25029443
neurotrophin receptor activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity

protein tyrosine kinase activity

transmembrane receptor protein tyrosine kinase activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity

protein tyrosine kinase activity

transmembrane receptor protein tyrosine kinase activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

catalytic activity, acting on a protein [inference]

protein kinase activity

protein tyrosine kinase activity

transmembrane receptor protein tyrosine kinase activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

binding [inference]

protein binding

signaling receptor binding [inference]

G protein-coupled receptor binding [inference]

frizzled binding

Wnt-protein binding

growth factor binding [inference]

neurotrophin binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

neurotrophin receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

protein kinase

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 8** entries
Gene Ontology
ATP binding
Wnt-protein binding
kinase activity
nucleotide binding
phosphorylation
positive regulation of neuron projection development
transmembrane receptor protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase signaling pathway

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InterPro
Frizzled cysteine-rich domain superfamily
Frizzled domain
Immunoglobulin-like domain
Kringle superfamily
Kringle, conserved site
Kringle-like fold
Kringle
Protein kinase domain
Protein kinase-like domain superfamily
Serine-threonine/tyrosine-protein kinase, catalytic domain

Alliance of Genome Resources

Expression

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Location	References
neuronal cell body membrane	PMID:15944127
axon	PMID:10476968 PMID:10556063
dendrite	PMID:10476968
neuromuscular junction	PMID:15944127 PMID:28515212
proximal dendrite	PMID:27151641
neuron projection	PMID:15944127
plasma membrane	PMID:10476968 PMID:10556063 PMID:14651925 PMID:17942487
cell-cell contact zone	PMID:29348144
obsolete cytoplasmic part	PMID:16049479
muscle cell projection	PMID:22464329

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0060764	autosomal recessive Robinow syndrome	Alliance of Genome Resources
DOID:0080263	autosomal recessive nonsyndromic deafness 108	Alliance of Genome Resources
DOID:0110969	brachydactyly type B1	Alliance of Genome Resources
DOID:674	cleft palate	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 15 in total

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Species	Gene ID	Alliance of Genome Resources
Homo sapiens	4919	HGNC:10256
Homo sapiens	4920	HGNC:10257
Mus musculus	26563	MGI:1347520
Mus musculus	26564	MGI:1347521
Drosophila melanogaster	34367	FB:FBgn0010407
Rattus norvegicus	306782	RGD:1305275
Rattus norvegicus	362550	RGD:1559469
Xenopus tropicalis	548551	Xenbase:XB-GENE-491498
Danio rerio	561183	ZFIN:ZDB-GENE-060427-5
Danio rerio	568282	ZFIN:ZDB-GENE-030131-6104

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements