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malate dehydrogenase 2, NAD (mitochondrial)

Summary

Gene Symbol

Mdh2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

17448

PubChem

17448

Alliance of Genome Resources

MGI:97050

Annotation

Keyword

Acetylation
Direct protein sequencing
Glycoprotein
Mitochondrion
NAD
Oxidoreductase
Phosphoprotein
Reference proteome
Transit peptide
Tricarboxylic acid cycle

Proteins

Displaying 1 entry
UniProt	Protein Name
P08249

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
malate metabolic process	ISA ISO	15809022
carboxylic acid metabolic process	IEA
NADH metabolic process	ISO
aerobic respiration	ISO
oxaloacetate metabolic process	ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process

organonitrogen compound metabolic process [inference]

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

aldehyde biosynthetic process [inference]

glyceraldehyde-3-phosphate biosynthetic process

small molecule biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

aldehyde biosynthetic process [inference]

glyceraldehyde-3-phosphate biosynthetic process

organophosphate biosynthetic process [inference]

glyceraldehyde-3-phosphate biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glyceraldehyde-3-phosphate biosynthetic process

cellular metabolic process [inference]

cellular aldehyde metabolic process [inference]

glyceraldehyde-3-phosphate metabolic process [inference]

glyceraldehyde-3-phosphate biosynthetic process

aldehyde biosynthetic process [inference]

glyceraldehyde-3-phosphate biosynthetic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process

dicarboxylic acid metabolic process [inference]

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

cellular respiration [inference]

aerobic respiration

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process

glyceraldehyde-3-phosphate metabolic process [inference]

glyceraldehyde-3-phosphate biosynthetic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process

glyceraldehyde-3-phosphate metabolic process [inference]

glyceraldehyde-3-phosphate biosynthetic process

organophosphate biosynthetic process [inference]

glyceraldehyde-3-phosphate biosynthetic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process

cellular biosynthetic process [inference]

aldehyde biosynthetic process [inference]

glyceraldehyde-3-phosphate biosynthetic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process [inference]

gluconeogenesis

hexose biosynthetic process [inference]

gluconeogenesis

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

tricarboxylic acid cycle

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process [inference]

gluconeogenesis

hexose biosynthetic process [inference]

gluconeogenesis

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process

dicarboxylic acid metabolic process [inference]

small molecule biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process [inference]

gluconeogenesis

hexose biosynthetic process [inference]

gluconeogenesis

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

cellular aldehyde metabolic process [inference]

glyceraldehyde-3-phosphate metabolic process [inference]

glyceraldehyde-3-phosphate biosynthetic process

aldehyde biosynthetic process [inference]

glyceraldehyde-3-phosphate biosynthetic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process

dicarboxylic acid metabolic process [inference]

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process

glyceraldehyde-3-phosphate metabolic process [inference]

glyceraldehyde-3-phosphate biosynthetic process

organophosphate biosynthetic process [inference]

glyceraldehyde-3-phosphate biosynthetic process

carbohydrate derivative metabolic process [inference]

glyceraldehyde-3-phosphate metabolic process [inference]

glyceraldehyde-3-phosphate biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glyceraldehyde-3-phosphate biosynthetic process

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process

organonitrogen compound metabolic process [inference]

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

aldehyde biosynthetic process [inference]

glyceraldehyde-3-phosphate biosynthetic process

organophosphate biosynthetic process [inference]

glyceraldehyde-3-phosphate biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glyceraldehyde-3-phosphate biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular aldehyde metabolic process [inference]

glyceraldehyde-3-phosphate metabolic process [inference]

glyceraldehyde-3-phosphate biosynthetic process

aldehyde biosynthetic process [inference]

glyceraldehyde-3-phosphate biosynthetic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process

dicarboxylic acid metabolic process [inference]

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

cellular respiration [inference]

aerobic respiration

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process

glyceraldehyde-3-phosphate metabolic process [inference]

glyceraldehyde-3-phosphate biosynthetic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process

glyceraldehyde-3-phosphate metabolic process [inference]

glyceraldehyde-3-phosphate biosynthetic process

organophosphate biosynthetic process [inference]

glyceraldehyde-3-phosphate biosynthetic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process

cellular biosynthetic process [inference]

aldehyde biosynthetic process [inference]

glyceraldehyde-3-phosphate biosynthetic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
mitochondrial inner membrane	HDA	12865426
cytosol
cytoplasm	IBA
myelin sheath	HDA	17634366
membrane	IMP	20080761

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane [inference]

mitochondrial inner membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

myelin sheath

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
catalytic activity	IEA
malate dehydrogenase (NADP+) activity	ISO
oxidoreductase activity	IEA
L-malate dehydrogenase activity	IBA IDA ISO	1203052 24134846 5496232
protein homodimerization activity

GO Hierarchy

molecular function

catalytic activity

oxidoreductase activity

oxidoreductase activity, acting on CH-OH group of donors [inference]

malate dehydrogenase activity

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

binding [inference]

protein binding [inference]

identical protein binding [inference]

protein homodimerization activity

protein self-association

protein dimerization activity [inference]

protein homodimerization activity

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0080433	developmental and epileptic encephalopathy 51	Alliance of Genome Resources
DOID:2316	brain ischemia	Alliance of Genome Resources
DOID:5844	myocardial infarction	Alliance of Genome Resources
DOID:6000	congestive heart failure	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 80 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	175936	WB:WBGene00003162
Drosophila melanogaster	39469	FB:FBgn0036327
Drosophila melanogaster	39470	FB:FBgn0036328
Drosophila melanogaster	42185	FB:FBgn0262559
Ciona intestinalis	100178529		CIOIN07600
Callorhinchus milii	103186901		CALMI35643
Latimeria chalumnae	102351122		LATCH18673
Danio rerio	406405	ZFIN:ZDB-GENE-040426-2143	DANRE01541
Astyanax mexicanus	103036822		ASTMX12148
Ictalurus punctatus	100528931		ICTPU09310

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Acknowledgements