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Sodium-dependent dopamine transporter

Summary

Gene Symbol

dat-1

Organism

Caenorhabditis elegans

External Links

NCBI Gene

176304

PubChem

176304

Alliance of Genome Resources

WB:WBGene00000934

Annotation

Keyword

Cell membrane
Disulfide bond
Glycoprotein
Metal-binding
Neurotransmitter transport
Reference proteome
Sodium
Symport
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q03614

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
positive regulation of locomotion involved in locomotory behavior	IMP	31083672
negative regulation of cellular response to oxidopamine	IMP	23721876
negative regulation of locomotion involved in locomotory behavior	IMP	20410438
dopamine uptake	IDA	15992384
amine transport	IMP	11867711

GO Hierarchy

biological process

cellular process [inference]

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organonitrogen compound [inference]

cellular response to amine stimulus [inference]

cellular response to amphetamine

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to amine stimulus [inference]

cellular response to amphetamine

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport

response to stimulus [inference]

response to endogenous stimulus [inference]

cellular response to endogenous stimulus [inference]

cellular response to organonitrogen compound [inference]

cellular response to amine stimulus [inference]

cellular response to amphetamine

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

response to amine [inference]

response to amphetamine [inference]

cellular response to amphetamine

cellular response to amine stimulus [inference]

cellular response to amphetamine

cellular response to organonitrogen compound [inference]

cellular response to amine stimulus [inference]

cellular response to amphetamine

cellular response to organic substance [inference]

cellular response to organonitrogen compound [inference]

cellular response to amine stimulus [inference]

cellular response to amphetamine

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organonitrogen compound [inference]

cellular response to amine stimulus [inference]

cellular response to amphetamine

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to amine stimulus [inference]

cellular response to amphetamine

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to amine [inference]

response to amphetamine [inference]

cellular response to amphetamine

cellular response to amine stimulus [inference]

cellular response to amphetamine

cellular response to organonitrogen compound [inference]

cellular response to amine stimulus [inference]

cellular response to amphetamine

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to amine stimulus [inference]

cellular response to amphetamine

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organonitrogen compound [inference]

cellular response to amine stimulus [inference]

cellular response to amphetamine

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to amine stimulus [inference]

cellular response to amphetamine

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

sodium ion transport [inference]

sodium ion transmembrane transport

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

monoatomic anion transport [inference]

chloride transport

chloride transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

neurotransmitter transport

neurotransmitter uptake [inference]

neurotransmitter reuptake [inference]

catecholamine uptake involved in synaptic transmission [inference]

dopamine uptake involved in synaptic transmission

inorganic anion transport [inference]

chloride transport

chloride transmembrane transport

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport

organic substance transport [inference]

organic cation transport [inference]

norepinephrine transport

norepinephrine uptake

organic anion transport [inference]

carboxylic acid transport [inference]

amino acid transport

amine transport

monoamine transport [inference]

catecholamine transport [inference]

dopamine transport [inference]

dopamine uptake

dopamine uptake involved in synaptic transmission

norepinephrine transport

norepinephrine uptake

catecholamine uptake [inference]

norepinephrine uptake

catecholamine uptake involved in synaptic transmission [inference]

dopamine uptake involved in synaptic transmission

dopamine uptake

dopamine uptake involved in synaptic transmission

organic acid transport [inference]

carboxylic acid transport [inference]

amino acid transport

organic hydroxy compound transport [inference]

catecholamine transport [inference]

dopamine transport [inference]

dopamine uptake

dopamine uptake involved in synaptic transmission

norepinephrine transport

norepinephrine uptake

catecholamine uptake [inference]

norepinephrine uptake

catecholamine uptake involved in synaptic transmission [inference]

dopamine uptake involved in synaptic transmission

dopamine uptake

dopamine uptake involved in synaptic transmission

nitrogen compound transport [inference]

monoamine transport [inference]

catecholamine transport [inference]

dopamine transport [inference]

dopamine uptake

dopamine uptake involved in synaptic transmission

norepinephrine transport

norepinephrine uptake

catecholamine uptake [inference]

norepinephrine uptake

catecholamine uptake involved in synaptic transmission [inference]

dopamine uptake involved in synaptic transmission

dopamine uptake

dopamine uptake involved in synaptic transmission

import into cell [inference]

neurotransmitter uptake [inference]

neurotransmitter reuptake [inference]

catecholamine uptake involved in synaptic transmission [inference]

dopamine uptake involved in synaptic transmission

establishment of localization in cell [inference]

neurotransmitter reuptake [inference]

catecholamine uptake involved in synaptic transmission [inference]

dopamine uptake involved in synaptic transmission

biological regulation [inference]

regulation of biological process [inference]

regulation of locomotion [inference]

negative regulation of locomotion [inference]

negative regulation of locomotion involved in locomotory behavior

positive regulation of locomotion [inference]

positive regulation of locomotion involved in locomotory behavior

regulation of locomotion involved in locomotory behavior [inference]

positive regulation of biological process [inference]

positive regulation of locomotion [inference]

positive regulation of locomotion involved in locomotory behavior

positive regulation of multicellular organismal process [inference]

positive regulation of behavior [inference]

positive regulation of locomotion involved in locomotory behavior

negative regulation of biological process [inference]

negative regulation of locomotion [inference]

negative regulation of locomotion involved in locomotory behavior

negative regulation of cellular process [inference]

negative regulation of response to stimulus [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of behavior [inference]

negative regulation of locomotion involved in locomotory behavior

regulation of response to stimulus [inference]

negative regulation of response to stimulus [inference]

regulation of cellular response to manganese ion [inference]

negative regulation of cellular response to manganese ion

regulation of cellular response to oxidopamine [inference]

negative regulation of cellular response to oxidopamine

regulation of cellular process [inference]

negative regulation of cellular process [inference]

regulation of cellular response to manganese ion [inference]

negative regulation of cellular response to manganese ion

regulation of cellular response to oxidopamine [inference]

negative regulation of cellular response to oxidopamine

regulation of multicellular organismal process [inference]

regulation of behavior [inference]

positive regulation of behavior [inference]

positive regulation of locomotion involved in locomotory behavior

negative regulation of behavior [inference]

negative regulation of locomotion involved in locomotory behavior

regulation of locomotion involved in locomotory behavior [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of behavior [inference]

positive regulation of locomotion involved in locomotory behavior

negative regulation of multicellular organismal process [inference]

negative regulation of behavior [inference]

negative regulation of locomotion involved in locomotory behavior

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
axon	IBA
neuronal cell body membrane	IBA IDA	15992384 31083672
plasma membrane	IBA IEA
synaptic membrane	IDA	31083672
membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

plasma membrane region [inference]

cell projection membrane [inference]

neuron projection membrane [inference]

synaptic membrane

presynaptic membrane

leading edge membrane [inference]

neuron projection membrane [inference]

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

cell body membrane [inference]

neuronal cell body membrane

Displaying **all 5** entries
GO Term	Evidence Code	PMID
chloride channel activity	IDA	15520385
metal ion binding	IEA
symporter activity	IEA
amine transmembrane transporter activity	IMP	11867711
dopamine:sodium symporter activity	IBA IDA	15520385 15992384 9765501

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

amine transmembrane transporter activity

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity

monoatomic cation transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

monoatomic anion:monoatomic cation symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

dopamine:sodium symporter activity

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity [inference]

dopamine:sodium symporter activity

solute:sodium symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

dopamine:sodium symporter activity

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

dopamine:sodium symporter activity

monoatomic anion transmembrane transporter activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity

chloride transmembrane transporter activity [inference]

chloride channel activity

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity [inference]

dopamine:sodium symporter activity

monoatomic anion:monoatomic cation symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

dopamine:sodium symporter activity

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity [inference]

dopamine:sodium symporter activity

active monoatomic ion transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

monoatomic anion:monoatomic cation symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

dopamine:sodium symporter activity

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity [inference]

dopamine:sodium symporter activity

solute:sodium symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

dopamine:sodium symporter activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic anion transmembrane transporter activity [inference]

chloride transmembrane transporter activity [inference]

chloride channel activity

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity [inference]

dopamine:sodium symporter activity

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

dopamine:sodium symporter activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity

active transmembrane transporter activity [inference]

monoamine transmembrane transporter activity [inference]

dopamine:sodium symporter activity

secondary active transmembrane transporter activity [inference]

symporter activity

solute:monoatomic cation symporter activity [inference]

monoatomic anion:monoatomic cation symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

dopamine:sodium symporter activity

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity [inference]

dopamine:sodium symporter activity

solute:sodium symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

dopamine:sodium symporter activity

active monoatomic ion transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

monoatomic anion:monoatomic cation symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

dopamine:sodium symporter activity

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity [inference]

dopamine:sodium symporter activity

solute:sodium symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

dopamine:sodium symporter activity

organic hydroxy compound transmembrane transporter activity [inference]

dopamine:sodium symporter activity

salt transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

dopamine:sodium symporter activity

chloride transmembrane transporter activity [inference]

chloride channel activity

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity [inference]

dopamine:sodium symporter activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

Alliance of Genome Resources

Expression

Displaying **all 7** entries
Location	References
dendrite	PMID:15992384 PMID:18094261 PMID:22908044 PMID:31083672
plasma membrane	PMID:15992384
axon	PMID:15992384 PMID:22908044
synapse	PMID:31083672
neuronal cell body	PMID:15992384 PMID:18094261 PMID:22908044 PMID:31083672
presynaptic membrane	PMID:18094261
presynaptic active zone	PMID:22908044

Disease

Disease Ontology

Displaying entries **11 - 18** of 18 in total

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DO ID	Disease Name	Source
DOID:11119	Gilles de la Tourette syndrome	Alliance of Genome Resources
DOID:11569	neurocirculatory asthenia	Alliance of Genome Resources
DOID:12700	hyperprolactinemia	Alliance of Genome Resources
DOID:1596	depressive disorder	Alliance of Genome Resources
DOID:3070	high grade glioma	Alliance of Genome Resources
DOID:5419	schizophrenia	Alliance of Genome Resources
DOID:9970	obesity	Alliance of Genome Resources
DOID:9976	heroin dependence	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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External Links

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International Collaboration

Acknowledgements