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Glutamate-gated chloride channel alpha

Summary

Gene Symbol

glc-1

Organism

Caenorhabditis elegans

External Links

NCBI Gene

180086

PubChem

180086

Alliance of Genome Resources

WB:WBGene00001591

Annotation

Keyword

3D-structure
Cell membrane
Chloride
Disulfide bond
Glycoprotein
Ion channel
Postsynaptic cell membrane
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
G5EBR3	Avermectin-sensitive glutamate-gated chloride channel GluCl alpha GluCl alpha

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
locomotion involved in locomotory behavior	IGI IMP	16527366
regulation of postsynaptic membrane potential	IEA
chloride transmembrane transport	IBA IDA	7935817
excitatory postsynaptic potential	IEA
ion transmembrane transport	IEA

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

transmembrane transport [inference]

monoatomic ion transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization

locomotion [inference]

locomotion involved in locomotory behavior

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport

monoatomic anion transport [inference]

chloride transport [inference]

chloride transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

monoatomic ion transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic anion transport [inference]

chloride transport [inference]

chloride transmembrane transport

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

regulation of biological quality [inference]

regulation of membrane potential

regulation of postsynaptic membrane potential

excitatory postsynaptic potential

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
membrane	IEA
postsynaptic membrane	IEA
plasma membrane	IBA IDA IEA	7935817
neuron projection	IBA
transmembrane transporter complex	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

transmembrane transporter complex

transporter complex [inference]

transmembrane transporter complex

cellular anatomical entity [inference]

membrane

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

postsynaptic membrane

cell junction [inference]

synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
extracellularly glutamate-gated chloride channel activity	IDA	7935817
neurotransmitter receptor activity	IBA
glutamate binding	IDA	21572436
identical protein binding	IPI	22884106 25143115
excitatory extracellular ligand-gated monoatomic ion channel activity	IBA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity

monoatomic anion channel activity [inference]

chloride channel activity

extracellularly glutamate-gated chloride channel activity

ligand-gated monoatomic anion channel activity [inference]

extracellularly glutamate-gated chloride channel activity

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity

excitatory extracellular ligand-gated monoatomic ion channel activity

extracellularly glutamate-gated ion channel activity [inference]

extracellularly glutamate-gated chloride channel activity

ligand-gated monoatomic anion channel activity [inference]

extracellularly glutamate-gated chloride channel activity

monoatomic anion transmembrane transporter activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity

extracellularly glutamate-gated chloride channel activity

ligand-gated monoatomic anion channel activity [inference]

extracellularly glutamate-gated chloride channel activity

chloride transmembrane transporter activity [inference]

chloride channel activity

extracellularly glutamate-gated chloride channel activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic anion transmembrane transporter activity [inference]

chloride transmembrane transporter activity [inference]

chloride channel activity

extracellularly glutamate-gated chloride channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity

monoatomic anion channel activity [inference]

chloride channel activity

extracellularly glutamate-gated chloride channel activity

ligand-gated monoatomic anion channel activity [inference]

extracellularly glutamate-gated chloride channel activity

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity

excitatory extracellular ligand-gated monoatomic ion channel activity

extracellularly glutamate-gated ion channel activity [inference]

extracellularly glutamate-gated chloride channel activity

ligand-gated monoatomic anion channel activity [inference]

extracellularly glutamate-gated chloride channel activity

gated channel activity [inference]

ligand-gated channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity

excitatory extracellular ligand-gated monoatomic ion channel activity

extracellularly glutamate-gated ion channel activity [inference]

extracellularly glutamate-gated chloride channel activity

ligand-gated monoatomic anion channel activity [inference]

extracellularly glutamate-gated chloride channel activity

salt transmembrane transporter activity [inference]

chloride transmembrane transporter activity [inference]

chloride channel activity

extracellularly glutamate-gated chloride channel activity

binding [inference]

protein binding [inference]

identical protein binding

amide binding [inference]

glutamate binding

small molecule binding [inference]

organic acid binding [inference]

carboxylic acid binding [inference]

amino acid binding [inference]

glutamate binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

amino acid binding [inference]

glutamate binding

molecular transducer activity [inference]

signaling receptor activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

glutamate-gated chloride channel

Functional Category

E: Amino acid transport and metabolism
T: Signal transduction mechanisms
X: Mobilome: prophages, transposons

Displaying **all 4** entries
Gene Ontology
chloride channel activity
extracellular ligand-gated monoatomic ion channel activity
monoatomic ion channel activity
monoatomic ion transport

Displaying **all 8** entries
InterPro
Gamma-aminobutyric acid A receptor/Glycine receptor alpha
Neuronal acetylcholine receptor
Neurotransmitter-gated ion-channel ligand-binding domain superfamily
Neurotransmitter-gated ion-channel ligand-binding domain
Neurotransmitter-gated ion-channel transmembrane domain superfamily
Neurotransmitter-gated ion-channel transmembrane domain
Neurotransmitter-gated ion-channel, conserved site
Neurotransmitter-gated ion-channel

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0060695	hyperekplexia	Alliance of Genome Resources
DOID:0060696	hyperekplexia 1	Alliance of Genome Resources
DOID:0060697	hyperekplexia 2	Alliance of Genome Resources
DOID:0070422	syndromic X-linked intellectual disability Pilorge type	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of 32 in total

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Species	Gene ID	Alliance of Genome Resources
Danio rerio	30676	ZFIN:ZDB-GENE-991117-1
Drosophila melanogaster	42350	FB:FBgn0024963
Danio rerio	83412	ZFIN:ZDB-GENE-010410-2
Danio rerio	83413	ZFIN:ZDB-GENE-010410-3
Mus musculus	110304	MGI:95749
Rattus norvegicus	114516	RGD:621229
Danio rerio	192124	ZFIN:ZDB-GENE-020402-1
Danio rerio	192125	ZFIN:ZDB-GENE-020402-2
Mus musculus	237213	MGI:95748
Rattus norvegicus	367912	RGD:1564103