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UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6

Summary

Gene Symbol

B3GNT6

Aliases

B3Gn-T6
core 3 synthase

Organism

Homo sapiens (human)

External Links

NCBI Gene

192134

GGDB ID

gg120

HGNC

24141

mRNA

NM_138706

map

11q13.4

Protein

NP_619651

OMIM

615315

KEGG Gene ID

hsa:192134

PubChem

192134

Alliance of Genome Resources

HGNC:24141

Annotation

Keyword

Alternative splicing
Glycoprotein
Glycosyltransferase
Golgi apparatus
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q6ZMB0	Core 3 synthase UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6
A8K9Q8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein O-linked glycosylation	IBA
poly-N-acetyllactosamine biosynthetic process	IBA
glycoprotein biosynthetic process	NAS	11821425
O-glycan processing	TAS
O-glycan processing, core 3	NAS	11821425

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

poly-N-acetyllactosamine biosynthetic process

poly-N-acetyllactosamine metabolic process [inference]

poly-N-acetyllactosamine biosynthetic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

O-glycan processing

O-glycan processing, core 3

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

poly-N-acetyllactosamine biosynthetic process

glycoprotein biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

poly-N-acetyllactosamine biosynthetic process

glycoprotein biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

poly-N-acetyllactosamine biosynthetic process

glycoprotein biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

poly-N-acetyllactosamine biosynthetic process

glycoprotein biosynthetic process

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

poly-N-acetyllactosamine biosynthetic process

glycoprotein biosynthetic process

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

poly-N-acetyllactosamine biosynthetic process

glycoprotein biosynthetic process

primary metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

O-glycan processing

O-glycan processing, core 3

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein O-linked glycosylation

O-glycan processing

O-glycan processing, core 3

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

poly-N-acetyllactosamine biosynthetic process

poly-N-acetyllactosamine metabolic process [inference]

poly-N-acetyllactosamine biosynthetic process

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

poly-N-acetyllactosamine biosynthetic process

glycoprotein biosynthetic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

O-glycan processing

O-glycan processing, core 3

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

O-glycan processing

O-glycan processing, core 3

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein O-linked glycosylation

O-glycan processing

O-glycan processing, core 3

carbohydrate derivative metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

poly-N-acetyllactosamine biosynthetic process

poly-N-acetyllactosamine metabolic process [inference]

poly-N-acetyllactosamine biosynthetic process

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

poly-N-acetyllactosamine biosynthetic process

glycoprotein biosynthetic process

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

poly-N-acetyllactosamine biosynthetic process

poly-N-acetyllactosamine metabolic process [inference]

poly-N-acetyllactosamine biosynthetic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

O-glycan processing

O-glycan processing, core 3

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

poly-N-acetyllactosamine biosynthetic process

glycoprotein biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

poly-N-acetyllactosamine biosynthetic process

glycoprotein biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

poly-N-acetyllactosamine biosynthetic process

glycoprotein biosynthetic process

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

poly-N-acetyllactosamine biosynthetic process

glycoprotein biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

poly-N-acetyllactosamine biosynthetic process

glycoprotein biosynthetic process

Displaying **all 2** entries
GO Term	Evidence Code	PMID
membrane	NAS	11821425
Golgi membrane	IBA TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
acetylgalactosaminyl-O-glycosyl-threonyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity	IEA
UDP-glycosyltransferase activity	IBA
galactosyltransferase activity	IBA IDA	11821425
UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity	TAS
beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity	NAS	11821425

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

UDP-glycosyltransferase activity

acetylglucosaminyltransferase activity [inference]

beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity

acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity [inference]

UDP-galactosyltransferase activity [inference]

UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity

hexosyltransferase activity [inference]

acetylglucosaminyltransferase activity [inference]

beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity

acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity [inference]

galactosyltransferase activity

UDP-galactosyltransferase activity [inference]

UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity

beta-1,3-galactosyltransferase activity [inference]

UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity

catalytic activity, acting on a protein [inference]

catalytic activity, acting on a glycoprotein [inference]

beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity

acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

GlycoGene Database (GGDB)

GGDB ID

gg120

Gene Symbol

B3GNT6

Reactions

Displaying 1 entry
Donor	Acceptor	Product	Reference
UDP-GlcNAc	G57321FI	G00035MO	11821425

Displaying 1 entry
Donor	Acceptor	Product	Reference
UDP-GlcNAc	G57321FI	G00035MO	11821425

Displaying entries **1 - 10** of 20 in total

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Donor	Acceptor	Reference
UDP-GlcNAc	G90562PB	11821425
UDP-GlcNAc	G58161NS	11821425
UDP-GlcNAc	G00033MO	11821425
UDP-GlcNAc	G84224TW	11821425
UDP-GlcNAc	G79333MY	11821425
UDP-GlcNAc	G00041MO	11821425
UDP-GlcNAc	G61418DU	11821425
UDP-GlcNAc	G65889KE	11821425
UDP-GlcNAc	G00035MO	11821425
UDP-GlcNAc	G96881BQ	11821425

Orthologous Gene

Displaying **all 2** entries
Species	Protein	mRNA
Rattus norvegicus	XP_217903	XM_217903
Mus musculus	XP_195661	XM_195661

KEGG BRITE Database

Orthology

K00739

Name

acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase [EC:2.4.1.147]

References

11821425

Reactions

Displaying 1 entry
KEGG Reaction	Enzyme	Acceptor	Product
R05909	2.4.1.147	G57321FI	G00035MO

Rhea

RHEA:46880

UDP-N-acetyl-α-D-glucosamine

H⁺ + UDP

Enzyme

2.4.1.147

PMID

RHEA:46884

UDP-N-acetyl-α-D-glucosamine

H⁺ + UDP

Enzyme

2.4.1.147

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of 13 in total

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DO ID	Disease Name	Source
DOID:0050424	familial adenomatous polyposis	DisGeNET
DOID:0080199	colorectal carcinoma	DisGeNET
DOID:0080409	familial adenomatous polyposis 1	DisGeNET
DOID:10283	prostate cancer	DisGeNET
DOID:10286	prostate carcinoma	DisGeNET
DOID:1520	colon carcinoma	DisGeNET
DOID:162	cancer	DisGeNET DisGeNET DisGeNET
DOID:1793	pancreatic cancer	DisGeNET DisGeNET
DOID:1799	islet cell tumor	DisGeNET
DOID:4766	embryoma	DisGeNET

Ortholog

Displaying entries **41 - 50** of 88 in total

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Species	Gene ID	Orthologous MAtrix
Pongo abelii	100447110	PONAB03802
Canis lupus familiaris	485176	CANLF08245
Ailuropoda melanoleuca	100477436	AILME01950
Felis catus	101088357	FELCA25970
Panthera leo	122201459	PANLE13651
Loxodonta africana	100655490	LOXAF04148
Equus caballus	100146508	HORSE39787
Bos taurus	540848	BOVIN07289
Capra hircus	102177179	CAPHI05517
Oryctolagus cuniculus	100351306	RABIT00791

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

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Other Information

Tools

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Summary

External Links

Annotation

GlycoGene Database (GGDB)

KEGG BRITE Database

International Collaboration

Acknowledgements