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dynein axonemal heavy chain 12

Summary

Gene Symbol

DNAH12

Organism

Homo sapiens (human)

External Links

NCBI Gene

201625

PubChem

201625

Alliance of Genome Resources

HGNC:2943

Annotation

Keyword

ATP-binding
Alternative splicing
Cilium
Coiled coil
Cytoskeleton
Dynein
Microtubule
Motor protein
Proteomics identification
Reference proteome
Repeat
Ubl conjugation pathway

Proteins

Displaying 1 entry
UniProt	Protein Name
Q6ZR08	Axonemal beta dynein heavy chain 12 Axonemal dynein heavy chain 12-like protein Axonemal dynein heavy chain 7-like protein Ciliary dynein heavy chain 12 Dynein axonemal heavy chain 7-like Dynein heavy chain domain-containing protein 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying 1 entry
GO Term	Evidence Code	PMID
microtubule-based movement	IEA

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule-based movement

Displaying **all 2** entries
GO Term	Evidence Code	PMID
microtubule	IEA
axonemal dynein complex	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

microtubule associated complex [inference]

dynein complex [inference]

axonemal dynein complex

catalytic complex [inference]

dynein complex [inference]

axonemal dynein complex

cellular anatomical entity [inference]

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule

Displaying **all 5** entries
GO Term	Evidence Code	PMID
minus-end-directed microtubule motor activity	IEA
dynein intermediate chain binding	IEA
ATP hydrolysis activity	IEA
dynein light intermediate chain binding	IEA
ATP binding	IEA

GO Hierarchy

molecular function

cytoskeletal motor activity [inference]

microtubule motor activity [inference]

minus-end-directed microtubule motor activity

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

binding [inference]

protein binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

microtubule motor activity [inference]

minus-end-directed microtubule motor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

heavy chain of dynein

Functional Category

J: Translation, ribosomal structure and biogenesis
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
ATP binding
dynein intermediate chain binding
dynein light intermediate chain binding
microtubule-based movement
minus-end-directed microtubule motor activity

Displaying entries **1 - 10** of 15 in total

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InterPro
Dynein heavy chain 3, AAA+ lid domain
Dynein heavy chain AAA lid domain superfamily
Dynein heavy chain AAA lid domain
Dynein heavy chain region D6 P-loop domain
Dynein heavy chain, AAA 5 extension domain
Dynein heavy chain, AAA module D4
Dynein heavy chain, AAA1 domain, small subdomain
Dynein heavy chain, ATP-binding dynein motor region
Dynein heavy chain, C-terminal domain
Dynein heavy chain, coiled coil stalk

Ortholog

Displaying entries **31 - 40** of 63 in total

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Species	Gene ID	Orthologous MAtrix
Callorhinchus milii	103176779	CALMI10890
Chlorocebus sabaeus	103227792	CHLSB10463
Callithrix jacchus	103796853	CALJA13060
Serinus canaria	103817154	SERCA11315
Rhinopithecus roxellana	104660204	RHIRO17446
Macaca nemestrina	105482662	MACNE24720
Mandrillus leucophaeus	105552696	MANLE03472
Cercocebus atys	105585613	CERAT02096
Aotus nancymaae	105722861	AOTNA23213
Salmo salar	106566599	SALSA27093

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements