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superoxide dismutase 1, soluble

Summary

Gene Symbol

Sod1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

20655

PubChem

20655

Alliance of Genome Resources

MGI:98351

Annotation

Keyword

3D-structure
Acetylation
Antioxidant
Copper
Cytoplasm
Direct protein sequencing
Disulfide bond
Metal-binding
Nucleus
Oxidoreductase
Palmitate
Phosphoprotein
Reference proteome
Zinc

Proteins

Displaying 1 entry
UniProt	Protein Name
P08228

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 56 in total

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GO Term	Evidence Code	PMID
negative regulation of developmental process	IMP	16036348
positive regulation of cytokine production	ISO ISS
transmission of nerve impulse	IMP	10433959
intracellular iron ion homeostasis	IMP	16377630
sensory perception of sound	IMP	10436316 10464373 16055286

GO Hierarchy

biological process

immune system process [inference]

myeloid cell homeostasis

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

hydrogen peroxide biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

hydrogen peroxide biosynthetic process

reactive oxygen species biosynthetic process [inference]

hydrogen peroxide biosynthetic process

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

hydrogen peroxide biosynthetic process

reactive oxygen species metabolic process

superoxide metabolic process

hydrogen peroxide metabolic process [inference]

hydrogen peroxide biosynthetic process

reactive oxygen species biosynthetic process [inference]

hydrogen peroxide biosynthetic process

organic substance metabolic process [inference]

glutathione metabolic process

hydrogen peroxide metabolic process [inference]

hydrogen peroxide biosynthetic process

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

hydrogen peroxide biosynthetic process

cellular process [inference]

microtubule-based process [inference]

microtubule-based movement [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

cell death [inference]

programmed cell death [inference]

apoptotic process

programmed cell death involved in cell development [inference]

ectopic germ cell programmed cell death

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

hydrogen peroxide biosynthetic process

reactive oxygen species metabolic process

superoxide metabolic process

hydrogen peroxide metabolic process [inference]

hydrogen peroxide biosynthetic process

reactive oxygen species biosynthetic process [inference]

hydrogen peroxide biosynthetic process

intermediate filament-based process [inference]

intermediate filament cytoskeleton organization [inference]

neurofilament cytoskeleton organization

cellular developmental process [inference]

programmed cell death involved in cell development [inference]

ectopic germ cell programmed cell death

cellular localization [inference]

intracellular transport [inference]

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

intermediate filament cytoskeleton organization [inference]

neurofilament cytoskeleton organization

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

inner ear receptor cell stereocilium organization [inference]

auditory receptor cell stereocilium organization

membrane organization [inference]

plasma membrane organization [inference]

myelin maintenance [inference]

peripheral nervous system myelin maintenance

cellular detoxification [inference]

cellular oxidant detoxification [inference]

removal of superoxide radicals

reproductive process [inference]

developmental process involved in reproduction [inference]

embryo implantation

multicellular organismal reproductive process [inference]

gamete generation [inference]

male gamete generation [inference]

spermatogenesis

multicellular organismal process [inference]

system process [inference]

muscle system process [inference]

relaxation of muscle [inference]

relaxation of smooth muscle [inference]

relaxation of vascular associated smooth muscle

circulatory system process [inference]

heart process [inference]

heart contraction

nervous system process [inference]

sensory perception [inference]

sensory perception of mechanical stimulus [inference]

sensory perception of sound

transmission of nerve impulse

behavior [inference]

locomotory behavior

determination of adult lifespan

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

myeloid cell homeostasis

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

retina homeostasis

developmental process [inference]

developmental process involved in reproduction [inference]

anatomical structure development [inference]

ovarian follicle development

cellular developmental process [inference]

programmed cell death involved in cell development [inference]

ectopic germ cell programmed cell death

homeostatic process [inference]

cellular homeostasis [inference]

muscle cell cellular homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular iron ion homeostasis

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

myeloid cell homeostasis

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

retina homeostasis

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular iron ion homeostasis

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular iron ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular iron ion homeostasis

inorganic ion homeostasis [inference]

intracellular iron ion homeostasis

response to stimulus [inference]

response to stress [inference]

response to oxidative stress

response to reactive oxygen species

response to oxygen radical [inference]

response to superoxide

response to hydrogen peroxide

response to heat

response to wounding [inference]

response to axon injury

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels

response to abiotic stimulus [inference]

response to temperature stimulus [inference]

response to heat

response to chemical [inference]

response to xenobiotic stimulus

response to organic substance [inference]

response to hydrogen peroxide

response to alcohol [inference]

response to ethanol

response to inorganic substance [inference]

response to oxygen radical [inference]

response to superoxide

response to metal ion [inference]

response to copper ion

response to hydrogen peroxide

response to oxygen-containing compound [inference]

response to reactive oxygen species

response to oxygen radical [inference]

response to superoxide

response to hydrogen peroxide

response to alcohol [inference]

response to ethanol

localization [inference]

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

microtubule-based transport [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

establishment of localization in cell [inference]

intracellular transport [inference]

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

cellular localization [inference]

intracellular transport [inference]

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of alcohol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

regulation of lipid biosynthetic process [inference]

regulation of steroid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

regulation of sterol biosynthetic process [inference]

regulation of cholesterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

regulation of alcohol biosynthetic process [inference]

regulation of cholesterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of alcohol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of alcohol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of lipid metabolic process [inference]

negative regulation of steroid metabolic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of cholesterol metabolic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of small molecule metabolic process [inference]

negative regulation of cholesterol metabolic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of alcohol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of reactive oxygen species metabolic process [inference]

positive regulation of superoxide anion generation

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of reactive oxygen species metabolic process [inference]

positive regulation of superoxide anion generation

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

regulation of protein kinase activity

regulation of kinase activity [inference]

regulation of protein kinase activity

regulation of reactive oxygen species metabolic process [inference]

regulation of superoxide metabolic process [inference]

regulation of superoxide anion generation [inference]

positive regulation of superoxide anion generation

positive regulation of reactive oxygen species metabolic process [inference]

positive regulation of superoxide anion generation

regulation of nitrogen compound metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

regulation of protein kinase activity

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

regulation of protein kinase activity

regulation of small molecule metabolic process [inference]

negative regulation of small molecule metabolic process [inference]

negative regulation of cholesterol metabolic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of alcohol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

regulation of cholesterol metabolic process [inference]

regulation of cholesterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of cholesterol metabolic process [inference]

negative regulation of cholesterol biosynthetic process

regulation of alcohol biosynthetic process [inference]

regulation of cholesterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of alcohol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

regulation of steroid metabolic process [inference]

negative regulation of steroid metabolic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of cholesterol metabolic process [inference]

negative regulation of cholesterol biosynthetic process

regulation of steroid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

regulation of sterol biosynthetic process [inference]

regulation of cholesterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

regulation of cholesterol metabolic process [inference]

regulation of cholesterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of cholesterol metabolic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of lipid metabolic process [inference]

negative regulation of steroid metabolic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of cholesterol metabolic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

regulation of lipid biosynthetic process [inference]

regulation of steroid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

regulation of sterol biosynthetic process [inference]

regulation of cholesterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

regulation of protein kinase activity

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

regulation of localization [inference]

regulation of transport [inference]

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of phagocytosis [inference]

positive regulation of phagocytosis

regulation of growth [inference]

regulation of developmental growth [inference]

regulation of multicellular organism growth

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of reactive oxygen species metabolic process [inference]

positive regulation of superoxide anion generation

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of reactive oxygen species metabolic process [inference]

positive regulation of superoxide anion generation

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of alcohol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of lipid metabolic process [inference]

negative regulation of steroid metabolic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of cholesterol metabolic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of lipid biosynthetic process [inference]

negative regulation of steroid biosynthetic process [inference]

negative regulation of sterol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of small molecule metabolic process [inference]

negative regulation of cholesterol metabolic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of alcohol biosynthetic process [inference]

negative regulation of cholesterol biosynthetic process

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of neuron apoptotic process

negative regulation of response to stimulus [inference]

negative regulation of defense response [inference]

negative regulation of inflammatory response

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response

negative regulation of developmental process

negative regulation of multicellular organismal process [inference]

negative regulation of muscle contraction [inference]

negative regulation of smooth muscle contraction [inference]

relaxation of vascular associated smooth muscle

negative regulation of reproductive process

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response

regulation of inflammatory response [inference]

negative regulation of inflammatory response

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of defense response [inference]

negative regulation of inflammatory response

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response

regulation of response to stress [inference]

regulation of defense response [inference]

negative regulation of defense response [inference]

negative regulation of inflammatory response

regulation of inflammatory response [inference]

negative regulation of inflammatory response

regulation of developmental process [inference]

regulation of developmental growth [inference]

regulation of multicellular organism growth

negative regulation of developmental process

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of reactive oxygen species metabolic process [inference]

positive regulation of superoxide anion generation

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

regulation of protein kinase activity

regulation of kinase activity [inference]

regulation of protein kinase activity

regulation of reactive oxygen species metabolic process [inference]

regulation of superoxide metabolic process [inference]

regulation of superoxide anion generation [inference]

positive regulation of superoxide anion generation

positive regulation of reactive oxygen species metabolic process [inference]

positive regulation of superoxide anion generation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

negative regulation of apoptotic process

negative regulation of neuron apoptotic process

regulation of neuron apoptotic process [inference]

negative regulation of neuron apoptotic process

regulation of apoptotic signaling pathway [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of neuron apoptotic process

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of reactive oxygen species metabolic process [inference]

positive regulation of superoxide anion generation

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of neuron apoptotic process

regulation of cellular component organization [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of phagocytosis [inference]

positive regulation of phagocytosis

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of phagocytosis [inference]

positive regulation of phagocytosis

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production

regulation of multicellular organism growth

regulation of system process [inference]

regulation of muscle system process [inference]

regulation of muscle contraction [inference]

regulation of smooth muscle contraction [inference]

negative regulation of smooth muscle contraction [inference]

relaxation of vascular associated smooth muscle

negative regulation of muscle contraction [inference]

negative regulation of smooth muscle contraction [inference]

relaxation of vascular associated smooth muscle

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production

negative regulation of multicellular organismal process [inference]

negative regulation of muscle contraction [inference]

negative regulation of smooth muscle contraction [inference]

relaxation of vascular associated smooth muscle

regulation of reproductive process [inference]

negative regulation of reproductive process

regulation of biological quality [inference]

regulation of blood pressure

regulation of membrane potential [inference]

action potential [inference]

regulation of mitochondrial membrane potential

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity

regulation of hydrolase activity [inference]

regulation of GTPase activity

regulation of transferase activity [inference]

regulation of kinase activity [inference]

regulation of protein kinase activity

detoxification [inference]

cellular detoxification [inference]

cellular oxidant detoxification [inference]

removal of superoxide radicals

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GO Term	Evidence Code	PMID
cytoplasmic vesicle	ISO ISS
secretory granule	ISO
peroxisome	IBA IEA ISO
protein-containing complex	ISO ISS
neuronal cell body	ISO ISS

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

cytoplasm

cytoplasmic region [inference]

plasma membrane bounded cell projection cytoplasm [inference]

neuron projection cytoplasm [inference]

cytosol

membrane [inference]

plasma membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

organelle envelope lumen [inference]

mitochondrial intermembrane space

myelin sheath

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

secretory vesicle [inference]

secretory granule

dense core granule

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

microbody [inference]

peroxisome

intracellular vesicle [inference]

cytoplasmic vesicle

secretory vesicle [inference]

secretory granule

dense core granule

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

microbody [inference]

peroxisome

intracellular vesicle [inference]

cytoplasmic vesicle

secretory vesicle [inference]

secretory granule

dense core granule

cell body [inference]

neuronal cell body

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GO Term	Evidence Code	PMID
protein binding	IPI	18219391 26643113 29128334 2960971
zinc ion binding	ISO ISS
enzyme binding	ISO
superoxide dismutase activity	IBA IDA IMP ISO TAS	10436316 10471451 10679476 11404260 11557311 12223545 12433839 12646716 12968068 14679182 15317809 16716900 291939 7444718 8673102 9516486 9788901
small GTPase binding	IEA ISO

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on superoxide radicals as acceptor [inference]

superoxide dismutase activity

binding [inference]

protein binding

enzyme binding

phosphatase binding [inference]

protein phosphatase binding [inference]

protein phosphatase 2B binding

GTPase binding [inference]

small GTPase binding

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

protein-folding chaperone binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

antioxidant activity [inference]

superoxide dismutase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

superoxide dismutase

Functional Category

O: Posttranslational modification, protein turnover, chaperones
P: Inorganic ion transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
copper ion binding
metal ion binding
oxidoreductase activity
removal of superoxide radicals
superoxide metabolic process

Displaying **all 4** entries
InterPro
Superoxide dismutase (Cu/Zn) / superoxide dismutase copper chaperone
Superoxide dismutase, copper/zinc binding domain
Superoxide dismutase, copper/zinc, binding site
Superoxide dismutase-like, copper/zinc binding domain superfamily

Disease

Disease Ontology

Displaying entries **1 - 10** of 40 in total

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DO ID	Disease Name	Source
DOID:0060193	amyotrophic lateral sclerosis type 1	Alliance of Genome Resources
DOID:0060224	atrial fibrillation	Alliance of Genome Resources
DOID:0080322	polycystic kidney disease	Alliance of Genome Resources
DOID:0080547	metabolic dysfunction-associated steatohepatitis	Alliance of Genome Resources
DOID:10140	dry eye syndrome	Alliance of Genome Resources
DOID:10584	retinitis pigmentosa	Alliance of Genome Resources
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:10763	hypertension	Alliance of Genome Resources
DOID:11446	sciatic neuropathy	Alliance of Genome Resources
DOID:11713	diabetic angiopathy	Alliance of Genome Resources

Ortholog

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	6647		HGNC:11179	HUMAN58256
Rattus norvegicus	24786	10116_1:003bbc	RGD:3731
Danio rerio	30553		ZFIN:ZDB-GENE-990415-258	DANRE01344
Drosophila melanogaster	36232		FB:FBgn0033631
Drosophila melanogaster	39251		FB:FBgn0003462
Caenorhabditis elegans	173776		WB:WBGene00007036
Caenorhabditis elegans	174141		WB:WBGene00004930
Bos taurus	281495			BOVIN14205
Sus scrofa	397036			PIGXX06047
Pan troglodytes	449637			PANTR25545

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements