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transformation related protein 53 binding protein 2

Summary

Gene Symbol

Trp53bp2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

209456

PubChem

209456

Alliance of Genome Resources

MGI:2138319

Annotation

Keyword

ANK repeat
Apoptosis
Cell cycle
Coiled coil
Cytoplasm
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
SH3 domain
SH3-binding

Proteins

Displaying **all 2** entries
UniProt	Protein Name
E9QJU8
Q8CG79	Tumor suppressor p53-binding protein 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
response to ionizing radiation	IMP	16702401
intrinsic apoptotic signaling pathway by p53 class mediator	ISO ISS
heart development	IMP	16702401
positive regulation of execution phase of apoptosis	ISO
embryo development ending in birth or egg hatching	IGI	16702401

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

signal transduction by p53 class mediator [inference]

intrinsic apoptotic signaling pathway by p53 class mediator

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway by p53 class mediator

apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway by p53 class mediator

multicellular organismal process [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching

developmental process [inference]

anatomical structure development [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching

animal organ development [inference]

heart development

system development [inference]

central nervous system development

response to stimulus [inference]

response to abiotic stimulus [inference]

response to radiation [inference]

response to ionizing radiation

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of execution phase of apoptosis

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

signal transduction by p53 class mediator [inference]

intrinsic apoptotic signaling pathway by p53 class mediator

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway by p53 class mediator

apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway by p53 class mediator

regulation of programmed cell death [inference]

regulation of apoptotic process

positive regulation of apoptotic process [inference]

positive regulation of execution phase of apoptosis

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of execution phase of apoptosis

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of execution phase of apoptosis

regulation of execution phase of apoptosis [inference]

positive regulation of execution phase of apoptosis

Displaying **all 5** entries
GO Term	Evidence Code	PMID
cell junction	ISO
nucleus	IBA ISO ISS
cytosol	ISO
perinuclear region of cytoplasm	IEA ISO
cytoplasm	ISO ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

perinuclear region of cytoplasm

Displaying **all 5** entries
GO Term	Evidence Code	PMID
NF-kappaB binding	ISO
SH3 domain binding	IEA
identical protein binding	ISO
p53 binding	IBA IEA ISO
protein homodimerization activity	ISO

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

p53 binding

transcription factor binding [inference]

DNA-binding transcription factor binding [inference]

RNA polymerase II-specific DNA-binding transcription factor binding [inference]

NF-kappaB binding

protein domain specific binding [inference]

SH3 domain binding

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

apoptosis-stimulating of p53 protein

Functional Category

I: Lipid transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
p53 binding
regulation of apoptotic process

Displaying **all 5** entries
InterPro
Ankyrin repeat-containing domain superfamily
Ankyrin repeat
Apoptosis-stimulating of p53 protein 1/2
SH3 domain
SH3-like domain superfamily

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0060412	chromosome 1q41-q42 deletion syndrome	Alliance of Genome Resources

Ortholog

Displaying entries **101 - 110** of **118** in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Onychomys torridus	118593056	38674_0:003342
Balaenoptera musculus	118898786		BALMU24838
Arvicola amphibius	119827717	1047088_0:0042a2
Microtus oregoni	121435897	111838_0:004b51
Dipodomys spectabilis	122109440	105255_0:0018bf
Marmota monax	124075607	9995_0:00054f
Sciurus carolinensis	124961747	30640_0:003cd5
Perognathus longimembris pacificus	125360102	214514_0:002b96
Myodes glareolus	125403872	447135_0:0016e8
Microtus fortis	126502110	100897_0:0016f8

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements