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transformation related protein 53 binding protein 2

Summary

Gene Symbol

Trp53bp2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

209456

PubChem

209456

Alliance of Genome Resources

MGI:2138319

Annotation

Keyword

ANK repeat
Apoptosis
Cell cycle
Coiled coil
Cytoplasm
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
SH3 domain
SH3-binding

Proteins

Displaying **all 2** entries
UniProt	Protein Name
E9QJU8
Q8CG79	Tumor suppressor p53-binding protein 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
response to ionizing radiation	IMP	16702401
intrinsic apoptotic signaling pathway by p53 class mediator	ISO ISS
heart development	IMP	16702401
positive regulation of execution phase of apoptosis	ISO
embryo development ending in birth or egg hatching	IGI	16702401

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

signal transduction by p53 class mediator [inference]

intrinsic apoptotic signaling pathway by p53 class mediator

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway by p53 class mediator

apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway by p53 class mediator

multicellular organismal process [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching

developmental process [inference]

anatomical structure development [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching

animal organ development [inference]

heart development

system development [inference]

central nervous system development

response to stimulus [inference]

response to abiotic stimulus [inference]

response to radiation [inference]

response to ionizing radiation

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of execution phase of apoptosis

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

signal transduction by p53 class mediator [inference]

intrinsic apoptotic signaling pathway by p53 class mediator

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway by p53 class mediator

apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway by p53 class mediator

regulation of programmed cell death [inference]

regulation of apoptotic process

positive regulation of apoptotic process [inference]

positive regulation of execution phase of apoptosis

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of execution phase of apoptosis

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of execution phase of apoptosis

regulation of execution phase of apoptosis [inference]

positive regulation of execution phase of apoptosis

Displaying **all 5** entries
GO Term	Evidence Code	PMID
cell junction	ISO
nucleus	IBA ISO ISS
cytosol	ISO
perinuclear region of cytoplasm	IEA ISO
cytoplasm	ISO ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

perinuclear region of cytoplasm

Displaying **all 5** entries
GO Term	Evidence Code	PMID
NF-kappaB binding	ISO
SH3 domain binding	IEA
identical protein binding	ISO
p53 binding	IBA IEA ISO
protein homodimerization activity	ISO

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

p53 binding

transcription factor binding [inference]

DNA-binding transcription factor binding [inference]

RNA polymerase II-specific DNA-binding transcription factor binding [inference]

NF-kappaB binding

protein domain specific binding [inference]

SH3 domain binding

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

apoptosis-stimulating of p53 protein

Functional Category

I: Lipid transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
p53 binding
regulation of apoptotic process

Displaying **all 5** entries
InterPro
Ankyrin repeat-containing domain superfamily
Ankyrin repeat
Apoptosis-stimulating of p53 protein 1/2
SH3 domain
SH3-like domain superfamily

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0060412	chromosome 1q41-q42 deletion syndrome	Alliance of Genome Resources

Ortholog

Displaying entries **81 - 90** of **118** in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Urocitellus parryii	113195577	9999_0:00339c
Pseudonaja textilis	113433239		PSETE03779
Bos indicus x Bos taurus	113906432		BOBOX05068
Marmota flaviventris	114092258	93162_0:004834
Podarcis muralis	114594631		PODMU17505
Grammomys surdaster	114640409	491861_0:003d5f
Peromyscus leucopus	114684419	10041_0:003840
Echeneis naucrates	115055046		ECHNA10085
Salmo trutta	115153209		SALTR08653
Salmo trutta	115193780		SALTR90545

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements