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5'-aminolevulinate synthase 1

Summary

Gene Symbol

ALAS1

Organism

Homo sapiens (human)

External Links

NCBI Gene

211

PubChem

211

Alliance of Genome Resources

HGNC:396

Annotation

Keyword

Acyltransferase
Alternative splicing
Heme biosynthesis
Hydroxylation
Membrane
Mitochondrion
Mitochondrion inner membrane
Pyridoxal phosphate
Reference proteome
Transit peptide
Ubl conjugation

Proteins

Displaying **all 3** entries
UniProt	Protein Name
B4DVA0	5-aminolevulinic acid synthase 1 Delta-ALA synthase 1 Delta-aminolevulinate synthase 1
P13196	5-aminolevulinic acid synthase 1 Delta-ALA synthase 1 Delta-aminolevulinate synthase 1
Q5JAM2	5-aminolevulinic acid synthase Delta-ALA synthase Delta-aminolevulinate synthase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
hemoglobin biosynthetic process	IBA
heme A biosynthetic process	IEA
heme O biosynthetic process	IEA
protoporphyrinogen IX biosynthetic process	IEA
heme biosynthetic process	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

hemoglobin metabolic process [inference]

hemoglobin biosynthetic process

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

heme metabolic process [inference]

heme biosynthetic process

heme a metabolic process [inference]

heme A biosynthetic process

heme B metabolic process [inference]

heme B biosynthetic process

heme O metabolic process [inference]

heme O biosynthetic process

protoporphyrinogen IX metabolic process [inference]

protoporphyrinogen IX biosynthetic process

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

organonitrogen compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

hemoglobin biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

hemoglobin biosynthetic process

heterocycle biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

aromatic compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

hemoglobin biosynthetic process

organic cyclic compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

organonitrogen compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

hemoglobin biosynthetic process

pigment metabolic process [inference]

heme metabolic process [inference]

heme biosynthetic process

heme a metabolic process [inference]

heme A biosynthetic process

heme B metabolic process [inference]

heme B biosynthetic process

heme O metabolic process [inference]

heme O biosynthetic process

pigment biosynthetic process [inference]

heme biosynthetic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

aromatic compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

heme metabolic process [inference]

heme biosynthetic process

heme a metabolic process [inference]

heme A biosynthetic process

heme B metabolic process [inference]

heme B biosynthetic process

heme O metabolic process [inference]

heme O biosynthetic process

protoporphyrinogen IX metabolic process [inference]

protoporphyrinogen IX biosynthetic process

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

hemoglobin biosynthetic process

heterocycle biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

aromatic compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

heterocycle metabolic process [inference]

heterocycle biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

heme metabolic process [inference]

heme biosynthetic process

heme a metabolic process [inference]

heme A biosynthetic process

heme B metabolic process [inference]

heme B biosynthetic process

heme O metabolic process [inference]

heme O biosynthetic process

protoporphyrinogen IX metabolic process [inference]

protoporphyrinogen IX biosynthetic process

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

primary metabolic process [inference]

protein metabolic process [inference]

hemoglobin metabolic process [inference]

hemoglobin biosynthetic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

hemoglobin biosynthetic process

protein metabolic process [inference]

hemoglobin metabolic process [inference]

hemoglobin biosynthetic process

organic cyclic compound metabolic process [inference]

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

heme metabolic process [inference]

heme biosynthetic process

heme a metabolic process [inference]

heme A biosynthetic process

heme B metabolic process [inference]

heme B biosynthetic process

heme O metabolic process [inference]

heme O biosynthetic process

protoporphyrinogen IX metabolic process [inference]

protoporphyrinogen IX biosynthetic process

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

organic cyclic compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

hemoglobin metabolic process [inference]

hemoglobin biosynthetic process

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

heme metabolic process [inference]

heme biosynthetic process

heme a metabolic process [inference]

heme A biosynthetic process

heme B metabolic process [inference]

heme B biosynthetic process

heme O metabolic process [inference]

heme O biosynthetic process

protoporphyrinogen IX metabolic process [inference]

protoporphyrinogen IX biosynthetic process

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

organonitrogen compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

hemoglobin biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

hemoglobin biosynthetic process

organic cyclic compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

organonitrogen compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

hemoglobin biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

aromatic compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

heme metabolic process [inference]

heme biosynthetic process

heme a metabolic process [inference]

heme A biosynthetic process

heme B metabolic process [inference]

heme B biosynthetic process

heme O metabolic process [inference]

heme O biosynthetic process

protoporphyrinogen IX metabolic process [inference]

protoporphyrinogen IX biosynthetic process

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

hemoglobin biosynthetic process

heterocycle biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

aromatic compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

heterocycle metabolic process [inference]

heterocycle biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

heme metabolic process [inference]

heme biosynthetic process

heme a metabolic process [inference]

heme A biosynthetic process

heme B metabolic process [inference]

heme B biosynthetic process

heme O metabolic process [inference]

heme O biosynthetic process

protoporphyrinogen IX metabolic process [inference]

protoporphyrinogen IX biosynthetic process

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

cellular developmental process [inference]

cell development [inference]

hemopoiesis [inference]

myeloid cell development [inference]

erythrocyte development

developmental process [inference]

anatomical structure development [inference]

cell development [inference]

hemopoiesis [inference]

myeloid cell development [inference]

erythrocyte development

cellular developmental process [inference]

cell development [inference]

hemopoiesis [inference]

myeloid cell development [inference]

erythrocyte development

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to organic cyclic compound [inference]

response to bile acid

response to lipid [inference]

response to bile acid

response to oxygen-containing compound [inference]

response to bile acid

Displaying **all 5** entries
GO Term	Evidence Code	PMID
mitochondrial inner membrane	IEA
nucleoplasm	IDA
mitochondrion	HTP IBA IDA	34800366
mitochondrial matrix	TAS
cytosol	IDA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane [inference]

mitochondrial inner membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	21516116 25416956 25910212 28514442 31515488 32296183 32814053 33961781
identical protein binding	IPI	25416956 32296183
pyridoxal phosphate binding	IEA
5-aminolevulinate synthase activity	IBA IDA	16234850 17975826

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity [inference]

acyltransferase activity, transferring groups other than amino-acyl groups [inference]

N-acyltransferase activity [inference]

N-succinyltransferase activity [inference]

5-aminolevulinate synthase activity

succinyltransferase activity [inference]

N-succinyltransferase activity [inference]

5-aminolevulinate synthase activity

binding [inference]

protein binding

identical protein binding

small molecule binding [inference]

vitamin binding [inference]

vitamin B6 binding [inference]

pyridoxal phosphate binding

heterocyclic compound binding [inference]

vitamin B6 binding [inference]

pyridoxal phosphate binding

ion binding [inference]

anion binding [inference]

pyridoxal phosphate binding

organic cyclic compound binding [inference]

vitamin B6 binding [inference]

pyridoxal phosphate binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

5-aminolevulinate synthase

Functional Category

E: Amino acid transport and metabolism
I: Lipid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 8** entries
Gene Ontology
5-aminolevulinate synthase activity
erythrocyte development
heme biosynthetic process
hemoglobin biosynthetic process
protoporphyrinogen IX biosynthetic process
pyridoxal phosphate binding
tetrapyrrole biosynthetic process
transferase activity

Displaying **all 6** entries
InterPro
Aminotransferase, class I/classII
Aminotransferase, class-II, pyridoxal-phosphate binding site
Pyridoxal phosphate-dependent transferase, major domain
Pyridoxal phosphate-dependent transferase, small domain
Pyridoxal phosphate-dependent transferase
Tetrapyrrole biosynthesis, 5-aminolevulinic acid synthase

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:13268	porphyria	Alliance of Genome Resources
DOID:13270	erythropoietic protoporphyria	Alliance of Genome Resources
DOID:6432	pulmonary hypertension	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 89 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	11655		MGI:87989	MOUSE60631
Drosophila melanogaster	37815		FB:FBgn0020764
Danio rerio	64608		ZFIN:ZDB-GENE-001229-2	DANRE02227
Rattus norvegicus	65155		RGD:68392	RATNO40505
Xenopus laevis	398824		Xenbase:XB-GENE-17343344
Xenopus laevis	444480		Xenbase:XB-GENE-975185
Pan troglodytes	460416	9598_0:000f21		PANTR31283
Canis lupus familiaris	476600			CANLF07442
Xenopus tropicalis	493434		Xenbase:XB-GENE-975179
Bos taurus	534286			BOVIN17720

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements