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two pore segment channel 2

Summary

Gene Symbol

TPCN2

Organism

Homo sapiens (human)

External Links

NCBI Gene

219931

PubChem

219931

Alliance of Genome Resources

HGNC:20820

JoGo

TPCN2

TogoVar

TPCN2

Annotation

Keyword

3D-structure
Calcium channel
Endosome
Glycoprotein
Lysosome
Proteomics identification
Reference proteome
Repeat
Signal
Transmembrane helix
Voltage-gated channel

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q59G56
Q8NHX9	Two pore calcium channel protein 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
intracellular calcium ion homeostasis	IDA	19387438
smooth muscle contraction	ISS
lysosome organization	IGI	25416817
regulation of autophagy	IGI	22012985
regulation of exocytosis	ISS

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor-mediated endocytosis of virus by host cell

endocytosis involved in viral entry into host cell

receptor-mediated endocytosis of virus by host cell

endosome to lysosome transport [inference]

endosome to lysosome transport of low-density lipoprotein particle

vesicle-mediated cholesterol transport [inference]

endosome to lysosome transport of low-density lipoprotein particle

cellular localization [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport [inference]

endosome to lysosome transport [inference]

endosome to lysosome transport of low-density lipoprotein particle

cytosolic transport [inference]

vesicle-mediated cholesterol transport [inference]

endosome to lysosome transport of low-density lipoprotein particle

intracellular lipid transport [inference]

intracellular sterol transport [inference]

intracellular cholesterol transport [inference]

vesicle-mediated cholesterol transport [inference]

endosome to lysosome transport of low-density lipoprotein particle

transmembrane transport [inference]

monoatomic ion transmembrane transport

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vacuole organization [inference]

lytic vacuole organization [inference]

lysosome organization

viral process [inference]

transport of virus [inference]

endocytosis involved in viral entry into host cell

receptor-mediated endocytosis of virus by host cell

multicellular organismal process [inference]

system process [inference]

muscle system process [inference]

muscle contraction [inference]

smooth muscle contraction

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction

monoatomic cation homeostasis [inference]

regulation of pH [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction

inorganic ion homeostasis [inference]

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis

response to stimulus [inference]

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to nutrient [inference]

response to vitamin [inference]

response to vitamin D

response to chemical [inference]

response to nutrient [inference]

response to vitamin [inference]

response to vitamin D

response to organic substance [inference]

response to organic cyclic compound [inference]

response to vitamin D

response to lipid [inference]

response to vitamin D

response to oxygen-containing compound [inference]

response to vitamin D

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

sodium ion transport [inference]

sodium ion transmembrane transport

calcium ion transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

monoatomic ion transmembrane transport

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor-mediated endocytosis of virus by host cell

endocytosis involved in viral entry into host cell

receptor-mediated endocytosis of virus by host cell

endosome to lysosome transport [inference]

endosome to lysosome transport of low-density lipoprotein particle

vesicle-mediated cholesterol transport [inference]

endosome to lysosome transport of low-density lipoprotein particle

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport [inference]

endosome to lysosome transport [inference]

endosome to lysosome transport of low-density lipoprotein particle

cytosolic transport [inference]

vesicle-mediated cholesterol transport [inference]

endosome to lysosome transport of low-density lipoprotein particle

intracellular lipid transport [inference]

intracellular sterol transport [inference]

intracellular cholesterol transport [inference]

vesicle-mediated cholesterol transport [inference]

endosome to lysosome transport of low-density lipoprotein particle

transmembrane transport [inference]

monoatomic ion transmembrane transport

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

organic substance transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

lipid transport [inference]

sterol transport [inference]

cholesterol transport [inference]

intracellular cholesterol transport [inference]

vesicle-mediated cholesterol transport [inference]

endosome to lysosome transport of low-density lipoprotein particle

intracellular sterol transport [inference]

intracellular cholesterol transport [inference]

vesicle-mediated cholesterol transport [inference]

endosome to lysosome transport of low-density lipoprotein particle

intracellular lipid transport [inference]

intracellular sterol transport [inference]

intracellular cholesterol transport [inference]

vesicle-mediated cholesterol transport [inference]

endosome to lysosome transport of low-density lipoprotein particle

organic hydroxy compound transport [inference]

sterol transport [inference]

cholesterol transport [inference]

intracellular cholesterol transport [inference]

vesicle-mediated cholesterol transport [inference]

endosome to lysosome transport of low-density lipoprotein particle

intracellular sterol transport [inference]

intracellular cholesterol transport [inference]

vesicle-mediated cholesterol transport [inference]

endosome to lysosome transport of low-density lipoprotein particle

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor-mediated endocytosis of virus by host cell

endocytosis involved in viral entry into host cell

receptor-mediated endocytosis of virus by host cell

establishment of localization in cell [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport [inference]

endosome to lysosome transport [inference]

endosome to lysosome transport of low-density lipoprotein particle

cytosolic transport [inference]

vesicle-mediated cholesterol transport [inference]

endosome to lysosome transport of low-density lipoprotein particle

intracellular lipid transport [inference]

intracellular sterol transport [inference]

intracellular cholesterol transport [inference]

vesicle-mediated cholesterol transport [inference]

endosome to lysosome transport of low-density lipoprotein particle

cellular localization [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport [inference]

endosome to lysosome transport [inference]

endosome to lysosome transport of low-density lipoprotein particle

cytosolic transport [inference]

vesicle-mediated cholesterol transport [inference]

endosome to lysosome transport of low-density lipoprotein particle

intracellular lipid transport [inference]

intracellular sterol transport [inference]

intracellular cholesterol transport [inference]

vesicle-mediated cholesterol transport [inference]

endosome to lysosome transport of low-density lipoprotein particle

biological regulation [inference]

regulation of pH [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of catabolic process [inference]

regulation of cellular catabolic process [inference]

regulation of autophagy

regulation of cellular metabolic process [inference]

regulation of cellular catabolic process [inference]

regulation of autophagy

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

regulation of secretion by cell [inference]

regulation of exocytosis

regulation of vesicle-mediated transport [inference]

regulation of exocytosis

regulation of sequestering of calcium ion [inference]

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

negative regulation of biological process [inference]

negative regulation of developmental pigmentation

negative regulation of cellular process [inference]

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

regulation of cellular metabolic process [inference]

regulation of cellular catabolic process [inference]

regulation of autophagy

negative regulation of cellular process [inference]

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

regulation of sequestering of calcium ion [inference]

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

regulation of vesicle-mediated transport [inference]

regulation of exocytosis

regulation of secretion by cell [inference]

regulation of exocytosis

regulation of pigmentation [inference]

regulation of developmental pigmentation [inference]

negative regulation of developmental pigmentation

regulation of biological quality [inference]

regulation of intracellular pH [inference]

intracellular pH reduction

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
lysosome	IDA	22012985
lysosomal membrane	TAS
lysosomal membrane	IDA	19387438 19620632 20880839 23063126
lysosomal membrane	IBA
cytosol	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex

cellular anatomical entity [inference]

cytosol

membrane [inference]

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

pigment granule membrane [inference]

melanosome membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

endolysosome membrane

endosome membrane

pigment granule membrane [inference]

melanosome membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
voltage-gated calcium channel activity	ISS
voltage-gated calcium channel activity	IDA	23063126
voltage-gated sodium channel activity	IDA	24776928
calcium channel activity	IDA	27140606
protein binding	IPI	21903581 23394946 24188827