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two pore segment channel 2

Summary

Gene Symbol

TPCN2

Organism

Homo sapiens (human)

External Links

NCBI Gene

219931

PubChem

219931

Alliance of Genome Resources

HGNC:20820

JoGo

TPCN2

TogoVar

TPCN2

Annotation

Keyword

3D-structure
Calcium channel
Endosome
Glycoprotein
Lysosome
Proteomics identification
Reference proteome
Repeat
Signal
Transmembrane helix
Voltage-gated channel

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q59G56
Q8NHX9	Two pore calcium channel protein 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **16 - 18** of 18 in total

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GO Term	Evidence Code	PMID
endocytosis involved in viral entry into host cell	IMP	25722412
endocytosis involved in viral entry into host cell	IBA
endosome to lysosome transport of low-density lipoprotein particle	ISS

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor-mediated endocytosis of virus by host cell

endocytosis involved in viral entry into host cell

receptor-mediated endocytosis of virus by host cell

endosome to lysosome transport [inference]

endosome to lysosome transport of low-density lipoprotein particle

vesicle-mediated cholesterol transport [inference]

endosome to lysosome transport of low-density lipoprotein particle

cellular localization [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport [inference]

endosome to lysosome transport [inference]

endosome to lysosome transport of low-density lipoprotein particle

cytosolic transport [inference]

vesicle-mediated cholesterol transport [inference]

endosome to lysosome transport of low-density lipoprotein particle

intracellular lipid transport [inference]

intracellular sterol transport [inference]

intracellular cholesterol transport [inference]

vesicle-mediated cholesterol transport [inference]

endosome to lysosome transport of low-density lipoprotein particle

transmembrane transport [inference]

monoatomic ion transmembrane transport

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vacuole organization [inference]

lytic vacuole organization [inference]

lysosome organization

viral process [inference]

transport of virus [inference]

endocytosis involved in viral entry into host cell

receptor-mediated endocytosis of virus by host cell

multicellular organismal process [inference]

system process [inference]

muscle system process [inference]

muscle contraction [inference]

smooth muscle contraction

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction

monoatomic cation homeostasis [inference]

regulation of pH [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction

inorganic ion homeostasis [inference]

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis

response to stimulus [inference]

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to nutrient [inference]

response to vitamin [inference]

response to vitamin D

response to chemical [inference]

response to nutrient [inference]

response to vitamin [inference]

response to vitamin D

response to organic substance [inference]

response to organic cyclic compound [inference]

response to vitamin D

response to lipid [inference]

response to vitamin D

response to oxygen-containing compound [inference]

response to vitamin D

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

sodium ion transport [inference]

sodium ion transmembrane transport

calcium ion transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

monoatomic ion transmembrane transport

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor-mediated endocytosis of virus by host cell

endocytosis involved in viral entry into host cell

receptor-mediated endocytosis of virus by host cell

endosome to lysosome transport [inference]

endosome to lysosome transport of low-density lipoprotein particle

vesicle-mediated cholesterol transport [inference]

endosome to lysosome transport of low-density lipoprotein particle

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport [inference]

endosome to lysosome transport [inference]

endosome to lysosome transport of low-density lipoprotein particle

cytosolic transport [inference]

vesicle-mediated cholesterol transport [inference]

endosome to lysosome transport of low-density lipoprotein particle

intracellular lipid transport [inference]

intracellular sterol transport [inference]

intracellular cholesterol transport [inference]

vesicle-mediated cholesterol transport [inference]

endosome to lysosome transport of low-density lipoprotein particle

transmembrane transport [inference]

monoatomic ion transmembrane transport

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

organic substance transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

lipid transport [inference]

sterol transport [inference]

cholesterol transport [inference]

intracellular cholesterol transport [inference]

vesicle-mediated cholesterol transport [inference]

endosome to lysosome transport of low-density lipoprotein particle

intracellular sterol transport [inference]

intracellular cholesterol transport [inference]

vesicle-mediated cholesterol transport [inference]

endosome to lysosome transport of low-density lipoprotein particle

intracellular lipid transport [inference]

intracellular sterol transport [inference]

intracellular cholesterol transport [inference]

vesicle-mediated cholesterol transport [inference]

endosome to lysosome transport of low-density lipoprotein particle

organic hydroxy compound transport [inference]

sterol transport [inference]

cholesterol transport [inference]

intracellular cholesterol transport [inference]

vesicle-mediated cholesterol transport [inference]

endosome to lysosome transport of low-density lipoprotein particle

intracellular sterol transport [inference]

intracellular cholesterol transport [inference]

vesicle-mediated cholesterol transport [inference]

endosome to lysosome transport of low-density lipoprotein particle

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor-mediated endocytosis of virus by host cell

endocytosis involved in viral entry into host cell

receptor-mediated endocytosis of virus by host cell

establishment of localization in cell [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport [inference]

endosome to lysosome transport [inference]

endosome to lysosome transport of low-density lipoprotein particle

cytosolic transport [inference]

vesicle-mediated cholesterol transport [inference]

endosome to lysosome transport of low-density lipoprotein particle

intracellular lipid transport [inference]

intracellular sterol transport [inference]

intracellular cholesterol transport [inference]

vesicle-mediated cholesterol transport [inference]

endosome to lysosome transport of low-density lipoprotein particle

cellular localization [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport [inference]

endosome to lysosome transport [inference]

endosome to lysosome transport of low-density lipoprotein particle

cytosolic transport [inference]

vesicle-mediated cholesterol transport [inference]

endosome to lysosome transport of low-density lipoprotein particle

intracellular lipid transport [inference]

intracellular sterol transport [inference]

intracellular cholesterol transport [inference]

vesicle-mediated cholesterol transport [inference]

endosome to lysosome transport of low-density lipoprotein particle

biological regulation [inference]

regulation of pH [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of catabolic process [inference]

regulation of cellular catabolic process [inference]

regulation of autophagy

regulation of cellular metabolic process [inference]

regulation of cellular catabolic process [inference]

regulation of autophagy

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

regulation of secretion by cell [inference]

regulation of exocytosis

regulation of vesicle-mediated transport [inference]

regulation of exocytosis

regulation of sequestering of calcium ion [inference]

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

negative regulation of biological process [inference]

negative regulation of developmental pigmentation

negative regulation of cellular process [inference]

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

regulation of cellular metabolic process [inference]

regulation of cellular catabolic process [inference]

regulation of autophagy

negative regulation of cellular process [inference]

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

regulation of sequestering of calcium ion [inference]

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

regulation of vesicle-mediated transport [inference]

regulation of exocytosis

regulation of secretion by cell [inference]

regulation of exocytosis

regulation of pigmentation [inference]

regulation of developmental pigmentation [inference]

negative regulation of developmental pigmentation

regulation of biological quality [inference]

regulation of intracellular pH [inference]

intracellular pH reduction

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
lysosome	IDA	22012985
lysosomal membrane	TAS
lysosomal membrane	IDA	19387438 19620632 20880839 23063126
lysosomal membrane	IBA
cytosol	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex

cellular anatomical entity [inference]

cytosol

membrane [inference]

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

pigment granule membrane [inference]

melanosome membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

endolysosome membrane

endosome membrane

pigment granule membrane [inference]

melanosome membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
voltage-gated calcium channel activity	ISS
voltage-gated calcium channel activity	IDA	23063126
voltage-gated sodium channel activity	IDA	24776928
calcium channel activity	IDA	27140606
protein binding	IPI	21903581 23394946 24188827