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cadherin related 23 (otocadherin)

Summary

Gene Symbol

Cdh23

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

22295

PubChem

22295

Alliance of Genome Resources

MGI:1890219

Annotation

Keyword

3D-structure
Alternative splicing
Calcium
Cell adhesion
Cell membrane
Disease variant
Glycoprotein
Hearing
Metal-binding
Non-syndromic deafness
Proteomics identification
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
K4DI74
Q99PF4	Otocadherin

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 29 in total

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GO Term	Evidence Code	PMID
calcium ion transport	ISO
calcium ion transport	IEA
cell adhesion	TAS	11138009
homophilic cell adhesion via plasma membrane adhesion molecules	IEA
sensory perception of sound	ISO

GO Hierarchy

biological process

cellular process [inference]

cell adhesion

cell-cell adhesion [inference]

cell-cell adhesion via plasma-membrane adhesion molecules

cellular developmental process [inference]

cell differentiation [inference]

neuron differentiation [inference]

hair cell differentiation [inference]

inner ear auditory receptor cell differentiation

mechanoreceptor differentiation [inference]

inner ear receptor cell differentiation [inference]

inner ear auditory receptor cell differentiation

epithelial cell differentiation [inference]

epidermal cell differentiation [inference]

hair cell differentiation [inference]

inner ear auditory receptor cell differentiation

cell motility [inference]

cell migration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development

inner ear receptor cell stereocilium organization

auditory receptor cell stereocilium organization

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of light stimulus

sensory perception of mechanical stimulus [inference]

sensory perception of sound

equilibrioception

behavior [inference]

locomotory behavior

adult locomotory behavior

adult behavior [inference]

adult locomotory behavior

photoreceptor cell maintenance

developmental process [inference]

anatomical structure morphogenesis [inference]

embryonic morphogenesis [inference]

inner ear morphogenesis

anatomical structure development [inference]

cellular developmental process [inference]

cell differentiation [inference]

neuron differentiation [inference]

hair cell differentiation [inference]

inner ear auditory receptor cell differentiation

mechanoreceptor differentiation [inference]

inner ear receptor cell differentiation [inference]

inner ear auditory receptor cell differentiation

epithelial cell differentiation [inference]

epidermal cell differentiation [inference]

hair cell differentiation [inference]

inner ear auditory receptor cell differentiation

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

regulation of cytosolic calcium ion concentration

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

regulation of cytosolic calcium ion concentration

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

regulation of cytosolic calcium ion concentration

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis [inference]

regulation of cytosolic calcium ion concentration

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

regulation of cytosolic calcium ion concentration

inorganic ion homeostasis [inference]

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis [inference]

regulation of cytosolic calcium ion concentration

response to stimulus [inference]

response to external stimulus [inference]

reflex [inference]

righting reflex

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport

organic substance transport [inference]

calcium ion transport

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
photoreceptor inner segment	IDA	14578428
centrosome	IDA	15882574
plasma membrane	TAS
catenin complex	IBA
stereocilium	IDA	12485990 15882574 16481439 17050716

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

catenin complex

cellular anatomical entity [inference]

photoreceptor inner segment

microtubule organizing center [inference]

centrosome

membrane [inference]

plasma membrane

cell junction [inference]

synapse

ribbon synapse [inference]

stereocilium tip

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium [inference]

non-motile cilium [inference]

9+2 non-motile cilium [inference]

kinocilium

neuron projection [inference]

actin-based cell projection [inference]

stereocilium

organelle [inference]

membrane-bounded organelle [inference]

cilium [inference]

non-motile cilium [inference]

9+2 non-motile cilium [inference]

kinocilium

apical part of cell

Displaying **all 4** entries
GO Term	Evidence Code	PMID
calcium ion binding	IEA
protein binding	IPI	12485990 15590703 15928608 17805295 19270079 20498078 23135401 24920589
beta-catenin binding	IBA
cadherin binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

beta-catenin binding

cell adhesion molecule binding [inference]

cadherin binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Cadherin

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 2** entries
Gene Ontology
calcium ion binding
homophilic cell adhesion via plasma membrane adhesion molecules

Displaying **all 2** entries
InterPro
Cadherin-like superfamily
Cadherin-like

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0110467	autosomal recessive nonsyndromic deafness 12	Alliance of Genome Resources
DOID:0110831	Usher syndrome type 1D	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of 51 in total

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Species	Gene ID	Orthologous MAtrix
Sus scrofa	100157198	PIGXX07765
Oryctolagus cuniculus	100337921	RABIT06718
Callithrix jacchus	100399125	CALJA07567
Pongo abelii	100442295	PONAB01379
Meleagris gallopavo	100544447	MELGA12456
Nomascus leucogenys	100592679	NOMLE14876
Loxodonta africana	100674230	LOXAF15726
Canis lupus familiaris	100684999	CANLF14654
Cavia porcellus	100712756	CAVPO08703
Cricetulus griseus	100760032	CRIGR19090

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements