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four and a half LIM domains 1

Summary

Gene Symbol

FHL1

Organism

Homo sapiens (human)

External Links

NCBI Gene

2273

PubChem

2273

Alliance of Genome Resources

HGNC:3702

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Cytoplasm
Developmental protein
Differentiation
Direct protein sequencing
Disease variant
Emery-Dreifuss muscular dystrophy
Isopeptide bond
LIM domain
Nucleus
Proteomics identification
Reference proteome
Repeat
Ubl conjugation
Zinc-finger

Proteins

Displaying **all 3** entries
UniProt	Protein Name
B7Z9A1
Q5JXI2
Q13642	Skeletal muscle LIM-protein 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
regulation of membrane depolarization	IDA	18281375
muscle organ development	NAS	7626119
animal organ morphogenesis	NAS	7626119
negative regulation of G2/M transition of mitotic cell cycle	IDA	21702045
cell differentiation	IEA

GO Hierarchy

biological process

cellular process [inference]

cellular developmental process [inference]

cell differentiation

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis

anatomical structure development [inference]

animal organ development [inference]

muscle organ development

muscle structure development [inference]

muscle organ development

cellular developmental process [inference]

cell differentiation

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

regulation of potassium ion transmembrane transporter activity

regulation of monoatomic ion transmembrane transport [inference]

regulation of monoatomic cation transmembrane transport [inference]

regulation of potassium ion transmembrane transport [inference]

regulation of potassium ion transmembrane transporter activity

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of potassium ion transport [inference]

positive regulation of potassium ion transport

regulation of potassium ion transmembrane transport [inference]

regulation of potassium ion transmembrane transporter activity

regulation of monoatomic ion transmembrane transport [inference]

regulation of monoatomic cation transmembrane transport [inference]

regulation of potassium ion transmembrane transport [inference]

regulation of potassium ion transmembrane transporter activity

positive regulation of monoatomic ion transport [inference]

positive regulation of potassium ion transport

positive regulation of transport [inference]

positive regulation of monoatomic ion transport [inference]

positive regulation of potassium ion transport

regulation of growth [inference]

regulation of cell growth [inference]

negative regulation of cell growth

negative regulation of growth [inference]

negative regulation of cell growth

positive regulation of biological process [inference]

positive regulation of transport [inference]

positive regulation of monoatomic ion transport [inference]

positive regulation of potassium ion transport

negative regulation of biological process [inference]

negative regulation of growth [inference]

negative regulation of cell growth

negative regulation of cellular process [inference]

negative regulation of cell growth

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of cell cycle phase transition [inference]

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of cell cycle G2/M phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle

negative regulation of cell cycle G1/S phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle

negative regulation of mitotic cell cycle [inference]

negative regulation of mitotic cell cycle phase transition [inference]

regulation of cellular process [inference]

regulation of membrane depolarization

regulation of transmembrane transport [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

regulation of potassium ion transmembrane transporter activity

regulation of monoatomic ion transmembrane transport [inference]

regulation of monoatomic cation transmembrane transport [inference]

regulation of potassium ion transmembrane transport [inference]

regulation of potassium ion transmembrane transporter activity

negative regulation of cellular process [inference]

negative regulation of cell growth

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of cell cycle phase transition [inference]

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of cell cycle G2/M phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle

negative regulation of cell cycle G1/S phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle

negative regulation of mitotic cell cycle [inference]

negative regulation of mitotic cell cycle phase transition [inference]

regulation of cellular component organization [inference]

regulation of cell growth [inference]

negative regulation of cell growth

regulation of cell cycle [inference]

regulation of mitotic cell cycle [inference]

negative regulation of mitotic cell cycle [inference]

negative regulation of mitotic cell cycle phase transition [inference]

regulation of mitotic cell cycle phase transition [inference]

regulation of G2/M transition of mitotic cell cycle [inference]

negative regulation of G2/M transition of mitotic cell cycle

negative regulation of mitotic cell cycle phase transition [inference]

regulation of G1/S transition of mitotic cell cycle [inference]

negative regulation of G1/S transition of mitotic cell cycle

regulation of cell cycle process [inference]

negative regulation of cell cycle process [inference]

negative regulation of cell cycle phase transition [inference]

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of cell cycle G2/M phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle

negative regulation of cell cycle G1/S phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle

regulation of cell cycle phase transition [inference]

negative regulation of cell cycle phase transition [inference]

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of cell cycle G2/M phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle

negative regulation of cell cycle G1/S phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle

regulation of mitotic cell cycle phase transition [inference]

regulation of G2/M transition of mitotic cell cycle [inference]

negative regulation of G2/M transition of mitotic cell cycle

negative regulation of mitotic cell cycle phase transition [inference]

regulation of G1/S transition of mitotic cell cycle [inference]

negative regulation of G1/S transition of mitotic cell cycle

regulation of cell cycle G2/M phase transition [inference]

regulation of G2/M transition of mitotic cell cycle [inference]

negative regulation of G2/M transition of mitotic cell cycle

negative regulation of cell cycle G2/M phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle

regulation of cell cycle G1/S phase transition [inference]

negative regulation of cell cycle G1/S phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle

regulation of G1/S transition of mitotic cell cycle [inference]

negative regulation of G1/S transition of mitotic cell cycle

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of cell cycle phase transition [inference]

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of cell cycle G2/M phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle

negative regulation of cell cycle G1/S phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle

negative regulation of mitotic cell cycle [inference]

negative regulation of mitotic cell cycle phase transition [inference]

regulation of biological quality [inference]

regulation of membrane potential [inference]

regulation of membrane depolarization

regulation of molecular function [inference]

regulation of transporter activity [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

regulation of potassium ion transmembrane transporter activity

Displaying **all 5** entries
GO Term	Evidence Code	PMID
nucleus	IDA	21702045
cytoplasm	IDA	21702045
cytosol	IDA
plasma membrane	IDA	18281375
focal adhesion	HDA	21423176

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

cell junction [inference]

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	18482256 19401155 20969868 21900206 23414517 28671123 35271311
zinc ion binding	IEA
transmembrane transporter binding	IBA
transmembrane transporter binding	IPI	18281375
metal ion binding

GO Hierarchy

molecular function

binding [inference]

protein binding

transmembrane transporter binding

ion binding [inference]

cation binding [inference]

metal ion binding

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

LIM domain

Functional Category

E: Amino acid transport and metabolism
I: Lipid transport and metabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
metal ion binding

Displaying 1 entry
InterPro
Zinc finger, LIM-type

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0070251	X-linked Emery-Dreifuss muscular dystrophy 6	Alliance of Genome Resources
DOID:0080090	reducing body myopathy 1A	Alliance of Genome Resources
DOID:0080687	reducing body myopathy 1B	Alliance of Genome Resources
DOID:0112148	Uruguay faciocardiomusculoskeletal syndrome	Alliance of Genome Resources

Ortholog

Displaying entries **31 - 40** of 76 in total

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Species	Gene ID	Orthologous MAtrix
Felis catus	101098207	FELCA38886
Oryzias latipes	101165816	ORYLA00997
Tursiops truncatus	101319185	TURTR06250
Octodon degus	101576837	OCTDE21712
Jaculus jaculus	101603479	JACJA05518
Mustela putorius furo	101683449	MUSPF04334
Heterocephalus glaber	101702039	HETGA25621
Ficedula albicollis	101808609	FICAL06673
Melopsittacus undulatus	101881752	MELUD08609
Chrysemys picta bellii	101938033	CHRPI11895