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four and a half LIM domains 1

Summary

Gene Symbol

FHL1

Organism

Homo sapiens (human)

External Links

NCBI Gene

2273

PubChem

2273

Alliance of Genome Resources

HGNC:3702

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Cytoplasm
Developmental protein
Differentiation
Direct protein sequencing
Disease variant
Emery-Dreifuss muscular dystrophy
Isopeptide bond
LIM domain
Nucleus
Proteomics identification
Reference proteome
Repeat
Ubl conjugation
Zinc-finger

Proteins

Displaying **all 3** entries
UniProt	Protein Name
B7Z9A1
Q5JXI2
Q13642	Skeletal muscle LIM-protein 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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2

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GO Term	Evidence Code	PMID
negative regulation of G2/M transition of mitotic cell cycle	IDA	21702045
negative regulation of cell growth	IDA	21702045
positive regulation of potassium ion transport	IDA	18281375
regulation of membrane depolarization	IDA	18281375
regulation of potassium ion transmembrane transporter activity	IDA	18281375

GO Hierarchy

biological process

cellular process [inference]

cellular developmental process [inference]

cell differentiation

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis

anatomical structure development [inference]

animal organ development [inference]

muscle organ development

muscle structure development [inference]

muscle organ development

cellular developmental process [inference]

cell differentiation

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

regulation of potassium ion transmembrane transporter activity

regulation of monoatomic ion transmembrane transport [inference]

regulation of monoatomic cation transmembrane transport [inference]

regulation of potassium ion transmembrane transport [inference]

regulation of potassium ion transmembrane transporter activity

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of potassium ion transport [inference]

positive regulation of potassium ion transport

regulation of potassium ion transmembrane transport [inference]

regulation of potassium ion transmembrane transporter activity

regulation of monoatomic ion transmembrane transport [inference]

regulation of monoatomic cation transmembrane transport [inference]

regulation of potassium ion transmembrane transport [inference]

regulation of potassium ion transmembrane transporter activity

positive regulation of monoatomic ion transport [inference]

positive regulation of potassium ion transport

positive regulation of transport [inference]

positive regulation of monoatomic ion transport [inference]

positive regulation of potassium ion transport

regulation of growth [inference]

regulation of cell growth [inference]

negative regulation of cell growth

negative regulation of growth [inference]

negative regulation of cell growth

positive regulation of biological process [inference]

positive regulation of transport [inference]

positive regulation of monoatomic ion transport [inference]

positive regulation of potassium ion transport

negative regulation of biological process [inference]

negative regulation of growth [inference]

negative regulation of cell growth

negative regulation of cellular process [inference]

negative regulation of cell growth

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of cell cycle phase transition [inference]

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of cell cycle G2/M phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle

negative regulation of cell cycle G1/S phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle

negative regulation of mitotic cell cycle [inference]

negative regulation of mitotic cell cycle phase transition [inference]

regulation of cellular process [inference]

regulation of membrane depolarization

regulation of transmembrane transport [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

regulation of potassium ion transmembrane transporter activity

regulation of monoatomic ion transmembrane transport [inference]

regulation of monoatomic cation transmembrane transport [inference]

regulation of potassium ion transmembrane transport [inference]

regulation of potassium ion transmembrane transporter activity

negative regulation of cellular process [inference]

negative regulation of cell growth

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of cell cycle phase transition [inference]

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of cell cycle G2/M phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle

negative regulation of cell cycle G1/S phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle

negative regulation of mitotic cell cycle [inference]

negative regulation of mitotic cell cycle phase transition [inference]

regulation of cellular component organization [inference]

regulation of cell growth [inference]

negative regulation of cell growth

regulation of cell cycle [inference]

regulation of mitotic cell cycle [inference]

negative regulation of mitotic cell cycle [inference]

negative regulation of mitotic cell cycle phase transition [inference]

regulation of mitotic cell cycle phase transition [inference]

regulation of G2/M transition of mitotic cell cycle [inference]

negative regulation of G2/M transition of mitotic cell cycle

negative regulation of mitotic cell cycle phase transition [inference]

regulation of G1/S transition of mitotic cell cycle [inference]

negative regulation of G1/S transition of mitotic cell cycle

regulation of cell cycle process [inference]

negative regulation of cell cycle process [inference]

negative regulation of cell cycle phase transition [inference]

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of cell cycle G2/M phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle

negative regulation of cell cycle G1/S phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle

regulation of cell cycle phase transition [inference]

negative regulation of cell cycle phase transition [inference]

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of cell cycle G2/M phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle

negative regulation of cell cycle G1/S phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle

regulation of mitotic cell cycle phase transition [inference]

regulation of G2/M transition of mitotic cell cycle [inference]

negative regulation of G2/M transition of mitotic cell cycle

negative regulation of mitotic cell cycle phase transition [inference]

regulation of G1/S transition of mitotic cell cycle [inference]

negative regulation of G1/S transition of mitotic cell cycle

regulation of cell cycle G2/M phase transition [inference]

regulation of G2/M transition of mitotic cell cycle [inference]

negative regulation of G2/M transition of mitotic cell cycle

negative regulation of cell cycle G2/M phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle

regulation of cell cycle G1/S phase transition [inference]

negative regulation of cell cycle G1/S phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle

regulation of G1/S transition of mitotic cell cycle [inference]

negative regulation of G1/S transition of mitotic cell cycle

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of cell cycle phase transition [inference]

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of cell cycle G2/M phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle

negative regulation of cell cycle G1/S phase transition [inference]

negative regulation of G1/S transition of mitotic cell cycle

negative regulation of mitotic cell cycle [inference]

negative regulation of mitotic cell cycle phase transition [inference]

regulation of biological quality [inference]

regulation of membrane potential [inference]

regulation of membrane depolarization

regulation of molecular function [inference]

regulation of transporter activity [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

regulation of potassium ion transmembrane transporter activity

Displaying **all 5** entries
GO Term	Evidence Code	PMID
focal adhesion	HDA	21423176
plasma membrane	IDA	18281375
nucleus	IDA	21702045
cytosol	IDA
cytoplasm	IDA	21702045

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

cell junction [inference]

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	18482256 19401155 20969868 21900206 23414517 28671123 35271311
metal ion binding	IEA
transmembrane transporter binding	IBA IPI	18281375
molecular_function	ND

GO Hierarchy

molecular function

binding [inference]

protein binding

transmembrane transporter binding

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

LIM domain

Functional Category

E: Amino acid transport and metabolism
I: Lipid transport and metabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
metal ion binding

Displaying 1 entry
InterPro
Zinc finger, LIM-type

Disease

Disease Ontology

Displaying **all 7** entries
DO ID	Disease Name	Source
DOID:0060253	scapuloperoneal myopathy	Alliance of Genome Resources
DOID:0070251	X-linked Emery-Dreifuss muscular dystrophy 6	Alliance of Genome Resources
DOID:0080090	reducing body myopathy 1A	Alliance of Genome Resources
DOID:0080687	reducing body myopathy 1B	Alliance of Genome Resources
DOID:0112148	Uruguay faciocardiomusculoskeletal syndrome	Alliance of Genome Resources
DOID:11984	hypertrophic cardiomyopathy	Alliance of Genome Resources
DOID:423	myopathy	Alliance of Genome Resources

Ortholog

Displaying entries **61 - 70** of 82 in total

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Species	Gene ID	Orthologous MAtrix
Equus asinus asinus	106838772	EQUAS32009
Sinocyclocheilus grahami	107560651	SINGR17925
Sinocyclocheilus grahami	107601127	SINGR64555
Cyprinus carpio carpio	109061985	CYPCA89922
Crocodylus porosus	109311005	CROPO18624
Phascolarctos cinereus	110196502	PHACI27989
Pseudonaja textilis	113446743	PSETE20116
Athene cunicularia	113480125	ATHCN13496
Electrophorus electricus	113583046	ELEEL31618
Vombatus ursinus	114024740	VOMUR27794