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phospholipase A2 receptor 1

Summary

Gene Symbol

PLA2R1

Aliases

CLEC13C
PLA2-R
PLA2G1R
PLA2IR

Organism

Homo sapiens (human)

External Links

NCBI Gene

22925

HGNC

9042

KEGG Gene ID

hsa:22925

PubChem

22925

Alliance of Genome Resources

HGNC:9042

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Disulfide bond
Endocytosis
Glycoprotein
Lectin
Receptor
Reference proteome
Repeat
Secreted
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
B7ZML4	180 kDa secretory phospholipase A2 receptor M-type receptor
Q13018	180 kDa secretory phospholipase A2 receptor C-type lectin domain family 13 member C M-type receptor

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 10 in total

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GO Term	Evidence Code	PMID
replicative senescence	IMP	19197340
positive regulation of podocyte apoptotic process	IMP	25335547
positive regulation of cytokine production	IMP	15611272
receptor-mediated endocytosis	IEA
negative regulation of phospholipase A2 activity	ISS

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

reactive oxygen species metabolic process

cellular senescence [inference]

stress-induced premature senescence [inference]

oxidative stress-induced premature senescence

replicative senescence

cellular process [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis

cellular metabolic process [inference]

reactive oxygen species metabolic process

cellular senescence [inference]

stress-induced premature senescence [inference]

oxidative stress-induced premature senescence

replicative senescence

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of signal transduction by p53 class mediator [inference]

positive regulation of DNA damage response, signal transduction by p53 class mediator

regulation of intracellular signal transduction [inference]

regulation of signal transduction by p53 class mediator [inference]

regulation of DNA damage response, signal transduction by p53 class mediator [inference]

positive regulation of DNA damage response, signal transduction by p53 class mediator

positive regulation of signal transduction by p53 class mediator [inference]

positive regulation of DNA damage response, signal transduction by p53 class mediator

positive regulation of intracellular signal transduction [inference]

positive regulation of signal transduction by p53 class mediator [inference]

positive regulation of DNA damage response, signal transduction by p53 class mediator

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of signal transduction by p53 class mediator [inference]

positive regulation of DNA damage response, signal transduction by p53 class mediator

regulation of localization [inference]

regulation of transport [inference]

regulation of lipid transport [inference]

negative regulation of lipid transport [inference]

negative regulation of fatty acid transport [inference]

negative regulation of icosanoid secretion [inference]

negative regulation of arachidonic acid secretion

positive regulation of lipid transport [inference]

positive regulation of fatty acid transport [inference]

positive regulation of icosanoid secretion [inference]

positive regulation of arachidonic acid secretion

regulation of fatty acid transport [inference]

regulation of icosanoid secretion [inference]

negative regulation of icosanoid secretion [inference]

negative regulation of arachidonic acid secretion

positive regulation of icosanoid secretion [inference]

positive regulation of arachidonic acid secretion

regulation of arachidonic acid secretion [inference]

negative regulation of fatty acid transport [inference]

negative regulation of icosanoid secretion [inference]

negative regulation of arachidonic acid secretion

positive regulation of fatty acid transport [inference]

positive regulation of icosanoid secretion [inference]

positive regulation of arachidonic acid secretion

regulation of organic acid transport [inference]

negative regulation of organic acid transport [inference]

negative regulation of fatty acid transport [inference]

negative regulation of icosanoid secretion [inference]

negative regulation of arachidonic acid secretion

positive regulation of organic acid transport [inference]

positive regulation of fatty acid transport [inference]

positive regulation of icosanoid secretion [inference]

positive regulation of arachidonic acid secretion

regulation of fatty acid transport [inference]

regulation of icosanoid secretion [inference]

negative regulation of icosanoid secretion [inference]

negative regulation of arachidonic acid secretion

positive regulation of icosanoid secretion [inference]

positive regulation of arachidonic acid secretion

regulation of arachidonic acid secretion [inference]

negative regulation of fatty acid transport [inference]

negative regulation of icosanoid secretion [inference]

negative regulation of arachidonic acid secretion

positive regulation of fatty acid transport [inference]

positive regulation of icosanoid secretion [inference]

positive regulation of arachidonic acid secretion

regulation of secretion [inference]

regulation of icosanoid secretion [inference]

negative regulation of icosanoid secretion [inference]

negative regulation of arachidonic acid secretion

positive regulation of icosanoid secretion [inference]

positive regulation of arachidonic acid secretion

regulation of arachidonic acid secretion [inference]

positive regulation of secretion [inference]

positive regulation of icosanoid secretion [inference]

positive regulation of arachidonic acid secretion

negative regulation of secretion [inference]

negative regulation of icosanoid secretion [inference]

negative regulation of arachidonic acid secretion

positive regulation of transport [inference]

positive regulation of lipid transport [inference]

positive regulation of fatty acid transport [inference]

positive regulation of icosanoid secretion [inference]

positive regulation of arachidonic acid secretion

positive regulation of organic acid transport [inference]

positive regulation of fatty acid transport [inference]

positive regulation of icosanoid secretion [inference]

positive regulation of arachidonic acid secretion

positive regulation of secretion [inference]

positive regulation of icosanoid secretion [inference]

positive regulation of arachidonic acid secretion

negative regulation of transport [inference]

negative regulation of lipid transport [inference]

negative regulation of fatty acid transport [inference]

negative regulation of icosanoid secretion [inference]

negative regulation of arachidonic acid secretion

negative regulation of organic acid transport [inference]

negative regulation of fatty acid transport [inference]

negative regulation of icosanoid secretion [inference]

negative regulation of arachidonic acid secretion

negative regulation of secretion [inference]

negative regulation of icosanoid secretion [inference]

negative regulation of arachidonic acid secretion

regulation of lipid localization [inference]

regulation of lipid transport [inference]

negative regulation of lipid transport [inference]

negative regulation of fatty acid transport [inference]

negative regulation of icosanoid secretion [inference]

negative regulation of arachidonic acid secretion

positive regulation of lipid transport [inference]

positive regulation of fatty acid transport [inference]

positive regulation of icosanoid secretion [inference]

positive regulation of arachidonic acid secretion

regulation of fatty acid transport [inference]

regulation of icosanoid secretion [inference]

negative regulation of icosanoid secretion [inference]

negative regulation of arachidonic acid secretion

positive regulation of icosanoid secretion [inference]

positive regulation of arachidonic acid secretion

regulation of arachidonic acid secretion [inference]

negative regulation of fatty acid transport [inference]

negative regulation of icosanoid secretion [inference]

negative regulation of arachidonic acid secretion

positive regulation of fatty acid transport [inference]

positive regulation of icosanoid secretion [inference]

positive regulation of arachidonic acid secretion

negative regulation of lipid localization [inference]

negative regulation of lipid transport [inference]

negative regulation of fatty acid transport [inference]

negative regulation of icosanoid secretion [inference]

negative regulation of arachidonic acid secretion

positive regulation of lipid localization [inference]

positive regulation of lipid transport [inference]

positive regulation of fatty acid transport [inference]

positive regulation of icosanoid secretion [inference]

positive regulation of arachidonic acid secretion

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of signal transduction by p53 class mediator [inference]

positive regulation of DNA damage response, signal transduction by p53 class mediator

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of signal transduction by p53 class mediator [inference]

positive regulation of DNA damage response, signal transduction by p53 class mediator

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of epithelial cell apoptotic process [inference]

positive regulation of podocyte apoptotic process

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of signal transduction by p53 class mediator [inference]

positive regulation of DNA damage response, signal transduction by p53 class mediator

positive regulation of transport [inference]

positive regulation of lipid transport [inference]

positive regulation of fatty acid transport [inference]

positive regulation of icosanoid secretion [inference]

positive regulation of arachidonic acid secretion

positive regulation of organic acid transport [inference]

positive regulation of fatty acid transport [inference]

positive regulation of icosanoid secretion [inference]

positive regulation of arachidonic acid secretion

positive regulation of secretion [inference]

positive regulation of icosanoid secretion [inference]

positive regulation of arachidonic acid secretion

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production

positive regulation of lipid localization [inference]

positive regulation of lipid transport [inference]

positive regulation of fatty acid transport [inference]

positive regulation of icosanoid secretion [inference]

positive regulation of arachidonic acid secretion

negative regulation of biological process [inference]

negative regulation of transport [inference]

negative regulation of lipid transport [inference]

negative regulation of fatty acid transport [inference]

negative regulation of icosanoid secretion [inference]

negative regulation of arachidonic acid secretion

negative regulation of organic acid transport [inference]

negative regulation of fatty acid transport [inference]

negative regulation of icosanoid secretion [inference]

negative regulation of arachidonic acid secretion

negative regulation of secretion [inference]

negative regulation of icosanoid secretion [inference]

negative regulation of arachidonic acid secretion

negative regulation of lipid localization [inference]

negative regulation of lipid transport [inference]

negative regulation of fatty acid transport [inference]

negative regulation of icosanoid secretion [inference]

negative regulation of arachidonic acid secretion

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of signal transduction by p53 class mediator [inference]

positive regulation of DNA damage response, signal transduction by p53 class mediator

regulation of intracellular signal transduction [inference]

regulation of signal transduction by p53 class mediator [inference]

regulation of DNA damage response, signal transduction by p53 class mediator [inference]

positive regulation of DNA damage response, signal transduction by p53 class mediator

positive regulation of signal transduction by p53 class mediator [inference]

positive regulation of DNA damage response, signal transduction by p53 class mediator

positive regulation of intracellular signal transduction [inference]

positive regulation of signal transduction by p53 class mediator [inference]

positive regulation of DNA damage response, signal transduction by p53 class mediator

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of signal transduction by p53 class mediator [inference]

positive regulation of DNA damage response, signal transduction by p53 class mediator

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of DNA damage response, signal transduction by p53 class mediator [inference]

positive regulation of DNA damage response, signal transduction by p53 class mediator

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of signal transduction by p53 class mediator [inference]

positive regulation of DNA damage response, signal transduction by p53 class mediator

regulation of intracellular signal transduction [inference]

regulation of signal transduction by p53 class mediator [inference]

regulation of DNA damage response, signal transduction by p53 class mediator [inference]

positive regulation of DNA damage response, signal transduction by p53 class mediator

positive regulation of signal transduction by p53 class mediator [inference]

positive regulation of DNA damage response, signal transduction by p53 class mediator

positive regulation of intracellular signal transduction [inference]

positive regulation of signal transduction by p53 class mediator [inference]

positive regulation of DNA damage response, signal transduction by p53 class mediator

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of signal transduction by p53 class mediator [inference]

positive regulation of DNA damage response, signal transduction by p53 class mediator

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process [inference]

positive regulation of epithelial cell apoptotic process [inference]

positive regulation of podocyte apoptotic process

regulation of epithelial cell apoptotic process [inference]

positive regulation of epithelial cell apoptotic process [inference]

positive regulation of podocyte apoptotic process

regulation of podocyte apoptotic process [inference]

positive regulation of podocyte apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of epithelial cell apoptotic process [inference]

positive regulation of podocyte apoptotic process

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of signal transduction by p53 class mediator [inference]

positive regulation of DNA damage response, signal transduction by p53 class mediator

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of epithelial cell apoptotic process [inference]

positive regulation of podocyte apoptotic process

regulation of cellular response to stress [inference]

regulation of DNA damage response, signal transduction by p53 class mediator [inference]

positive regulation of DNA damage response, signal transduction by p53 class mediator

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of lipase activity [inference]

negative regulation of phospholipase activity [inference]

negative regulation of phospholipase A2 activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of lipase activity [inference]

negative regulation of phospholipase activity [inference]

negative regulation of phospholipase A2 activity

regulation of hydrolase activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of lipase activity [inference]

negative regulation of phospholipase activity [inference]

negative regulation of phospholipase A2 activity

regulation of lipase activity [inference]

regulation of phospholipase activity [inference]

negative regulation of phospholipase activity [inference]

negative regulation of phospholipase A2 activity

regulation of phospholipase A2 activity [inference]

negative regulation of phospholipase A2 activity

negative regulation of lipase activity [inference]

negative regulation of phospholipase activity [inference]

negative regulation of phospholipase A2 activity

Displaying **all 4** entries
GO Term	Evidence Code	PMID
receptor complex	IBA IDA	23382219
extracellular region	ISS
cell surface	IDA	15611272
plasma membrane	IBA IDA	12225974

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
signaling receptor activity	IBA
carbohydrate binding	IEA
phospholipase binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

enzyme binding [inference]

phospholipase binding

carbohydrate binding

molecular transducer activity [inference]

signaling receptor activity

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000153246

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K06560

Name

mannose receptor, C type

References

Disease

Disease Ontology

Displaying entries **11 - 20** of 58 in total

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DO ID	Disease Name	Source
DOID:10966	lipoid nephrosis	DisGeNET
DOID:10976	membranous glomerulonephritis	DisGeNET DisGeNET
DOID:11400	pyelonephritis	DisGeNET DisGeNET
DOID:1184	nephrotic syndrome	DisGeNET
DOID:1240	leukemia	DisGeNET
DOID:12603	acute leukemia	DisGeNET
DOID:1312	focal segmental glomerulosclerosis	DisGeNET
DOID:1425	pyoureter	DisGeNET
DOID:1612	breast cancer	DisGeNET DisGeNET
DOID:162	cancer	DisGeNET DisGeNET DisGeNET

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP004318
Gene Name: phospholipase A2 receptor 1, 180kDa

Ortholog

Displaying entries **81 - 85** of 85 in total

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Species	Gene ID	Orthologous MAtrix
Propithecus coquereli	105819538	PROCO10801
Cyprinus carpio carpio	109051996	CYPCA125211
Corvus moneduloides	116446447	CORMO25057
Carlito syrichta	103261772	CARSF06767
Strigops habroptila	115608798	STRHB03689

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements