GlyCosmos Portal

Annotation

Keyword

3D-structure
ATP-binding
Acetylation
Alternative splicing
Apoptosis
Charcot-Marie-Tooth disease
Coiled coil
Cytoplasmic vesicle
Cytoskeleton
Disease variant
Isomerase
Membrane
Microtubule
Mitochondrion
Motor protein
Neurodegeneration
Phosphoprotein
Reference proteome
Synapse

Proteins

Displaying 1 entry
UniProt	Protein Name
O60333

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
mitochondrion transport along microtubule	IMP	16225668
vesicle-mediated transport	IBA
apoptotic process	IEA
microtubule-based movement
anterograde synaptic vesicle transport	ISS

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule-based movement

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

anterograde axonal transport [inference]

anterograde synaptic vesicle transport

retrograde axonal transport [inference]

retrograde neuronal dense core vesicle transport

organelle transport along microtubule [inference]

vesicle transport along microtubule [inference]

synaptic vesicle transport along microtubule [inference]

anterograde synaptic vesicle transport

retrograde neuronal dense core vesicle transport

mitochondrion transport along microtubule

establishment of mitochondrion localization, microtubule-mediated [inference]

mitochondrion transport along microtubule

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

cell death [inference]

programmed cell death [inference]

apoptotic process

apoptotic process involved in development

vesicle-mediated transport

synaptic vesicle transport [inference]

synaptic vesicle cytoskeletal transport [inference]

synaptic vesicle transport along microtubule [inference]

anterograde synaptic vesicle transport

cellular localization [inference]

intracellular transport [inference]

cytosolic transport [inference]

dense core granule transport [inference]

dense core granule cytoskeletal transport [inference]

retrograde neuronal dense core vesicle transport

cytoskeleton-dependent intracellular transport

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

anterograde axonal transport [inference]

anterograde synaptic vesicle transport

retrograde axonal transport [inference]

retrograde neuronal dense core vesicle transport

organelle transport along microtubule [inference]

vesicle transport along microtubule [inference]

synaptic vesicle transport along microtubule [inference]

anterograde synaptic vesicle transport

retrograde neuronal dense core vesicle transport

mitochondrion transport along microtubule

vesicle cytoskeletal trafficking [inference]

vesicle transport along microtubule [inference]

synaptic vesicle transport along microtubule [inference]

anterograde synaptic vesicle transport

retrograde neuronal dense core vesicle transport

synaptic vesicle cytoskeletal transport [inference]

synaptic vesicle transport along microtubule [inference]

anterograde synaptic vesicle transport

dense core granule cytoskeletal transport [inference]

retrograde neuronal dense core vesicle transport

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport

intracellular transport [inference]

cytosolic transport [inference]

dense core granule transport [inference]

dense core granule cytoskeletal transport [inference]

retrograde neuronal dense core vesicle transport

cytoskeleton-dependent intracellular transport

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

anterograde axonal transport [inference]

anterograde synaptic vesicle transport

retrograde axonal transport [inference]

retrograde neuronal dense core vesicle transport

organelle transport along microtubule [inference]

vesicle transport along microtubule [inference]

synaptic vesicle transport along microtubule [inference]

anterograde synaptic vesicle transport

retrograde neuronal dense core vesicle transport

mitochondrion transport along microtubule

vesicle cytoskeletal trafficking [inference]

vesicle transport along microtubule [inference]

synaptic vesicle transport along microtubule [inference]

anterograde synaptic vesicle transport

retrograde neuronal dense core vesicle transport

synaptic vesicle cytoskeletal transport [inference]

synaptic vesicle transport along microtubule [inference]

anterograde synaptic vesicle transport

dense core granule cytoskeletal transport [inference]

retrograde neuronal dense core vesicle transport

synaptic vesicle transport [inference]

synaptic vesicle cytoskeletal transport [inference]

synaptic vesicle transport along microtubule [inference]

anterograde synaptic vesicle transport

microtubule-based transport [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

anterograde axonal transport [inference]

anterograde synaptic vesicle transport

retrograde axonal transport [inference]

retrograde neuronal dense core vesicle transport

organelle transport along microtubule [inference]

vesicle transport along microtubule [inference]

synaptic vesicle transport along microtubule [inference]

anterograde synaptic vesicle transport

retrograde neuronal dense core vesicle transport

mitochondrion transport along microtubule

establishment of localization in cell [inference]

intracellular transport [inference]

cytosolic transport [inference]

dense core granule transport [inference]

dense core granule cytoskeletal transport [inference]

retrograde neuronal dense core vesicle transport

cytoskeleton-dependent intracellular transport

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

anterograde axonal transport [inference]

anterograde synaptic vesicle transport

retrograde axonal transport [inference]

retrograde neuronal dense core vesicle transport

organelle transport along microtubule [inference]

vesicle transport along microtubule [inference]

synaptic vesicle transport along microtubule [inference]

anterograde synaptic vesicle transport

retrograde neuronal dense core vesicle transport

mitochondrion transport along microtubule

vesicle cytoskeletal trafficking [inference]

vesicle transport along microtubule [inference]

synaptic vesicle transport along microtubule [inference]

anterograde synaptic vesicle transport

retrograde neuronal dense core vesicle transport

synaptic vesicle cytoskeletal transport [inference]

synaptic vesicle transport along microtubule [inference]

anterograde synaptic vesicle transport

dense core granule cytoskeletal transport [inference]

retrograde neuronal dense core vesicle transport

establishment of vesicle localization [inference]

synaptic vesicle transport [inference]

synaptic vesicle cytoskeletal transport [inference]

synaptic vesicle transport along microtubule [inference]

anterograde synaptic vesicle transport

vesicle cytoskeletal trafficking [inference]

vesicle transport along microtubule [inference]

synaptic vesicle transport along microtubule [inference]

anterograde synaptic vesicle transport

retrograde neuronal dense core vesicle transport

synaptic vesicle cytoskeletal transport [inference]

synaptic vesicle transport along microtubule [inference]

anterograde synaptic vesicle transport

dense core granule cytoskeletal transport [inference]

retrograde neuronal dense core vesicle transport

dense core granule transport [inference]

dense core granule cytoskeletal transport [inference]

retrograde neuronal dense core vesicle transport

establishment of organelle localization [inference]

establishment of vesicle localization [inference]

synaptic vesicle transport [inference]

synaptic vesicle cytoskeletal transport [inference]

synaptic vesicle transport along microtubule [inference]

anterograde synaptic vesicle transport

vesicle cytoskeletal trafficking [inference]

vesicle transport along microtubule [inference]

synaptic vesicle transport along microtubule [inference]

anterograde synaptic vesicle transport

retrograde neuronal dense core vesicle transport

synaptic vesicle cytoskeletal transport [inference]

synaptic vesicle transport along microtubule [inference]

anterograde synaptic vesicle transport

dense core granule cytoskeletal transport [inference]

retrograde neuronal dense core vesicle transport

dense core granule transport [inference]

dense core granule cytoskeletal transport [inference]

retrograde neuronal dense core vesicle transport

establishment of mitochondrion localization [inference]

establishment of mitochondrion localization, microtubule-mediated [inference]

mitochondrion transport along microtubule

organelle transport along microtubule [inference]

vesicle transport along microtubule [inference]

synaptic vesicle transport along microtubule [inference]

anterograde synaptic vesicle transport

retrograde neuronal dense core vesicle transport

mitochondrion transport along microtubule

organelle localization [inference]

mitochondrion localization [inference]

establishment of mitochondrion localization [inference]

establishment of mitochondrion localization, microtubule-mediated [inference]

mitochondrion transport along microtubule

vesicle localization [inference]

secretory granule localization [inference]

dense core granule localization [inference]

dense core granule transport [inference]

dense core granule cytoskeletal transport [inference]

retrograde neuronal dense core vesicle transport

establishment of vesicle localization [inference]

synaptic vesicle transport [inference]

synaptic vesicle cytoskeletal transport [inference]

synaptic vesicle transport along microtubule [inference]

anterograde synaptic vesicle transport

vesicle cytoskeletal trafficking [inference]

vesicle transport along microtubule [inference]

synaptic vesicle transport along microtubule [inference]

anterograde synaptic vesicle transport

retrograde neuronal dense core vesicle transport

synaptic vesicle cytoskeletal transport [inference]

synaptic vesicle transport along microtubule [inference]

anterograde synaptic vesicle transport

dense core granule cytoskeletal transport [inference]

retrograde neuronal dense core vesicle transport

dense core granule transport [inference]

dense core granule cytoskeletal transport [inference]

retrograde neuronal dense core vesicle transport

synaptic vesicle localization [inference]

synaptic vesicle transport [inference]

synaptic vesicle cytoskeletal transport [inference]

synaptic vesicle transport along microtubule [inference]

anterograde synaptic vesicle transport

establishment of organelle localization [inference]

establishment of vesicle localization [inference]

synaptic vesicle transport [inference]

synaptic vesicle cytoskeletal transport [inference]

synaptic vesicle transport along microtubule [inference]

anterograde synaptic vesicle transport

vesicle cytoskeletal trafficking [inference]

vesicle transport along microtubule [inference]

synaptic vesicle transport along microtubule [inference]

anterograde synaptic vesicle transport

retrograde neuronal dense core vesicle transport

synaptic vesicle cytoskeletal transport [inference]

synaptic vesicle transport along microtubule [inference]

anterograde synaptic vesicle transport

dense core granule cytoskeletal transport [inference]

retrograde neuronal dense core vesicle transport

dense core granule transport [inference]

dense core granule cytoskeletal transport [inference]

retrograde neuronal dense core vesicle transport

establishment of mitochondrion localization [inference]

establishment of mitochondrion localization, microtubule-mediated [inference]

mitochondrion transport along microtubule

organelle transport along microtubule [inference]

vesicle transport along microtubule [inference]

synaptic vesicle transport along microtubule [inference]

anterograde synaptic vesicle transport

retrograde neuronal dense core vesicle transport

mitochondrion transport along microtubule

cellular localization [inference]

intracellular transport [inference]

cytosolic transport [inference]

dense core granule transport [inference]

dense core granule cytoskeletal transport [inference]

retrograde neuronal dense core vesicle transport

cytoskeleton-dependent intracellular transport

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

anterograde axonal transport [inference]

anterograde synaptic vesicle transport

retrograde axonal transport [inference]

retrograde neuronal dense core vesicle transport

organelle transport along microtubule [inference]

vesicle transport along microtubule [inference]

synaptic vesicle transport along microtubule [inference]

anterograde synaptic vesicle transport

retrograde neuronal dense core vesicle transport

mitochondrion transport along microtubule

vesicle cytoskeletal trafficking [inference]

vesicle transport along microtubule [inference]

synaptic vesicle transport along microtubule [inference]

anterograde synaptic vesicle transport

retrograde neuronal dense core vesicle transport

synaptic vesicle cytoskeletal transport [inference]

synaptic vesicle transport along microtubule [inference]

anterograde synaptic vesicle transport

dense core granule cytoskeletal transport [inference]

retrograde neuronal dense core vesicle transport

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
microtubule	IBA
synaptic vesicle membrane	ISS
cytoplasmic vesicle	IBA ISS
neuron projection	ISS
kinesin complex	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

microtubule associated complex [inference]

kinesin complex

cellular anatomical entity [inference]

cytoplasm

cytoplasmic region [inference]

plasma membrane bounded cell projection cytoplasm [inference]

neuron projection cytoplasm [inference]

axon cytoplasm

membrane [inference]

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

bounding membrane of organelle [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular vesicle [inference]

cytoplasmic vesicle

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	12097473 16225668 20852589 25416956 32814053 35271311 36931259
kinesin binding	TAS	10341097
ATP hydrolysis activity	IBA
plus-end-directed microtubule motor activity	IBA IDA	16225668
microtubule binding	IBA

GO Hierarchy

molecular function

cytoskeletal motor activity [inference]

microtubule motor activity [inference]

plus-end-directed microtubule motor activity

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

isomerase activity

binding [inference]

protein binding

cytoskeletal protein binding [inference]

tubulin binding [inference]

microtubule binding

kinesin binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

microtubule motor activity [inference]

plus-end-directed microtubule motor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Kinesin

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
ATP binding
cytoskeletal motor activity
microtubule binding
microtubule-based movement
nucleotide binding

Displaying **all 5** entries
InterPro
Kinesin motor domain superfamily
Kinesin motor domain, conserved site
Kinesin motor domain
Kinesin-like protein
P-loop containing nucleoside triphosphate hydrolase

Disease

Disease Ontology

Displaying **all 8** entries
DO ID	Disease Name	Source
DOID:0050890	synucleinopathy	Alliance of Genome Resources
DOID:0110154	Charcot-Marie-Tooth disease type 2A1	Alliance of Genome Resources
DOID:2152	ovary epithelial cancer	Alliance of Genome Resources
DOID:2377	multiple sclerosis	Alliance of Genome Resources
DOID:332	amyotrophic lateral sclerosis	Alliance of Genome Resources
DOID:684	hepatocellular carcinoma	Alliance of Genome Resources
DOID:769	neuroblastoma	Alliance of Genome Resources
DOID:863	nervous system disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 78 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	16561	MGI:108426	MOUSE39918
Drosophila melanogaster	36876	FB:FBgn0267002
Rattus norvegicus	117548	RGD:621520	RATNO33276
Caenorhabditis elegans	174144	WB:WBGene00006831
Danio rerio	369190	ZFIN:ZDB-GENE-030820-1	DANRE24598
Canis lupus familiaris	479605		CANLF15827
Macaca mulatta	722674		MACMU23425
Equus caballus	100057126		HORSE28491
Ornithorhynchus anatinus	100078765		ORNAN21300
Oryctolagus cuniculus	100355710		RABIT04252

GlyTouCan

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Annotation

OrthoDB (Group)

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Acknowledgements