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protein O-fucosyltransferase 2

Summary

Gene Symbol

POFUT2

Aliases

FUT13
GDP-fucose protein O-fucosyltransferase 2
KIAA0958
peptide-O-fucosyltransferase

Organism

Homo sapiens (human)

External Links

NCBI Gene

23275

GGDB ID

gg013

HGNC

14683

mRNA

NM_133635

map

21q22.3

Protein

NP_598368

OMIM

610249

KEGG Gene ID

hsa:23275

PubChem

23275

Alliance of Genome Resources

HGNC:14683

Annotation

Keyword

3D-structure
Alternative splicing
Disulfide bond
Endoplasmic reticulum
Fucose metabolism
Glycoprotein
Glycosyltransferase
Golgi apparatus
Proteomics identification
Reference proteome
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
S6FW71	Peptide-O-fucosyltransferase 2
Q9Y2G5	Peptide-O-fucosyltransferase 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
positive regulation of protein folding	IMP	25544610
protein O-linked fucosylation	IDA TAS	22588082
regulation of epithelial to mesenchymal transition	IEA
regulation of gene expression	IEA
mesoderm formation	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked fucosylation

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fucose metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked fucosylation

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fucose metabolic process

glycosylation [inference]

fucosylation [inference]

protein O-linked fucosylation

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked fucosylation

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fucose metabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked fucosylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked fucosylation

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked fucosylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked fucosylation

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

formation of primary germ layer [inference]

mesoderm formation

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of protein folding

regulation of developmental process [inference]

regulation of cell differentiation [inference]

regulation of epithelial to mesenchymal transition

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of cell differentiation [inference]

regulation of epithelial to mesenchymal transition

positive regulation of cellular process [inference]

positive regulation of protein folding

regulation of protein folding [inference]

positive regulation of protein folding

Displaying **all 2** entries
GO Term	Evidence Code	PMID
Golgi apparatus	IDA	15233996
endoplasmic reticulum membrane	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

Displaying 1 entry
GO Term	Evidence Code	PMID
peptide-O-fucosyltransferase activity	IBA IDA TAS	22588082

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

hexosyltransferase activity [inference]

fucosyltransferase activity [inference]

peptide-O-fucosyltransferase activity

catalytic activity, acting on a protein [inference]

peptide-O-fucosyltransferase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 2

Functional Category

O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
fucose metabolic process
peptide-O-fucosyltransferase activity
protein O-linked fucosylation
transferase activity

Displaying **all 2** entries
InterPro
GDP-fucose protein O-fucosyltransferase 2-like
GDP-fucose protein O-fucosyltransferase

GlycoGene Database (GGDB)

GGDB ID

gg013

Gene Symbol

POFUT2

Orthologous Gene

Displaying **all 4** entries
Species	Protein	mRNA
Drosophila melanogaster	NP_569916	NM_130560
Rattus norvegicus	XP_228073	XM_228073
Caenorhabditis elegans	NP_741272	NM_171228
Mus musculus	NP_084538	NM_030262

KEGG BRITE Database

Orthology

K03691

Name

peptide-O-fucosyltransferase [EC:2.4.1.221]

References

11524432

Rhea

RHEA:70491

GDP-β-L-fucose

H⁺ + GDP

Enzyme

2.4.1.221

PMID

RHEA:63644

GDP-β-L-fucose

H⁺ + GDP

Enzyme

2.4.1.221

PMID

RHEA:70539

GDP-β-L-fucose

H⁺ + GDP

Enzyme

2.4.1.221

PMID

RHEA:70535

GDP-β-L-fucose

H⁺ + GDP

Enzyme

2.4.1.221

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:14250	Down syndrome	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of 66 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	779585		Xenbase:XB-GENE-1018927
Monodelphis domestica	100017276			MONDO00975
Ornithorhynchus anatinus	100076963			ORNAN25367
Taeniopygia guttata	100228829			TAEGU27684
Pongo abelii	100454664	9601_0:004ee5		PONAB21441
Nomascus leucogenys	100590705			NOMLE23704
Loxodonta africana	100664414			LOXAF02117
Cavia porcellus	100728767			CAVPO22539
Sus scrofa	100738385			PIGXX06293
Cricetulus griseus	100765129			CRIGR07596

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Summary

External Links

Annotation

OrthoDB (Group)

GlycoGene Database (GGDB)

KEGG BRITE Database

International Collaboration

Acknowledgements