GlyCosmos Portal

crumbs cell polarity complex component 1

Summary

Gene Symbol

CRB1

Organism

Homo sapiens (human)

External Links

NCBI Gene

23418

PubChem

23418

Alliance of Genome Resources

HGNC:2343

Annotation

Keyword

3D-structure
Alternative splicing
Calcium
Cell membrane
Cell projection
Disease variant
Disulfide bond
EGF-like domain
Glycoprotein
Leber congenital amaurosis
Proteomics identification
Reference proteome
Repeat
Retinitis pigmentosa
Secreted
Signal
Transmembrane helix

Proteins

Displaying **all 6** entries
UniProt	Protein Name
F5H0L2
P82279
A8K118
A0A7D6VM04
B7Z826
B7Z824

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 18 in total

1

2

3

4

Next ›

Last »
GO Term	Evidence Code	PMID
blood vessel remodeling	IEA
plasma membrane organization	IEA
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IBA
establishment or maintenance of cell polarity	TAS	10508521
cell-cell signaling	TAS	10508521

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular process [inference]

cell communication [inference]

cell-cell signaling

cell adhesion [inference]

cell-cell adhesion [inference]

cell-cell adhesion via plasma-membrane adhesion molecules [inference]

heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules

establishment or maintenance of cell polarity

establishment of cell polarity [inference]

establishment of bipolar cell polarity [inference]

establishment of bipolar cell polarity involved in cell morphogenesis

establishment or maintenance of bipolar cell polarity [inference]

establishment or maintenance of apical/basal cell polarity [inference]

establishment or maintenance of epithelial cell apical/basal polarity

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular developmental process [inference]

cell differentiation [inference]

glial cell differentiation

cell development [inference]

neuron development [inference]

photoreceptor cell development [inference]

eye photoreceptor cell development

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization

cellular response to stimulus [inference]

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus

cellular component organization or biogenesis [inference]

cellular component organization [inference]

photoreceptor cell outer segment organization

membrane organization [inference]

plasma membrane organization

multicellular organismal process [inference]

photoreceptor cell maintenance

tissue remodeling [inference]

blood vessel remodeling

developmental process [inference]

anatomical structure morphogenesis [inference]

post-embryonic animal morphogenesis [inference]

post-embryonic retina morphogenesis in camera-type eye

anatomical structure formation involved in morphogenesis [inference]

retina layer formation

anatomical structure development [inference]

cell development [inference]

neuron development [inference]

photoreceptor cell development [inference]

eye photoreceptor cell development

cellular developmental process [inference]

cell differentiation [inference]

glial cell differentiation

cell development [inference]

neuron development [inference]

photoreceptor cell development [inference]

eye photoreceptor cell development

response to stimulus [inference]

response to external stimulus [inference]

detection of external stimulus [inference]

detection of light stimulus [inference]

detection of visible light [inference]

detection of light stimulus involved in visual perception

detection of light stimulus involved in sensory perception [inference]

detection of light stimulus involved in visual perception

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus [inference]

detection of light stimulus [inference]

detection of visible light [inference]

detection of light stimulus involved in visual perception

detection of light stimulus involved in sensory perception [inference]

detection of light stimulus involved in visual perception

cellular response to light stimulus

cellular response to radiation [inference]

cellular response to light stimulus

detection of abiotic stimulus [inference]

detection of light stimulus [inference]

detection of visible light [inference]

detection of light stimulus involved in visual perception

detection of light stimulus involved in sensory perception [inference]

detection of light stimulus involved in visual perception

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus

detection of stimulus [inference]

detection of external stimulus [inference]

detection of light stimulus [inference]

detection of visible light [inference]

detection of light stimulus involved in visual perception

detection of light stimulus involved in sensory perception [inference]

detection of light stimulus involved in visual perception

detection of abiotic stimulus [inference]

detection of light stimulus [inference]

detection of visible light [inference]

detection of light stimulus involved in visual perception

detection of light stimulus involved in sensory perception [inference]

detection of light stimulus involved in visual perception

detection of stimulus involved in sensory perception [inference]

detection of light stimulus involved in sensory perception [inference]

detection of light stimulus involved in visual perception

cellular response to stimulus [inference]

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling

Displaying entries **1 - 5** of 12 in total

1

2

3

Next ›

Last »
GO Term	Evidence Code	PMID
photoreceptor outer segment	IEA
photoreceptor inner segment	IEA
extracellular region	IEA
plasma membrane	IBA
microvillus	IEA

GO Hierarchy

cellular component

protein-containing complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

subapical complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

apical plasma membrane

cell junction [inference]

anchoring junction [inference]

cell-cell junction [inference]

cell projection [inference]

plasma membrane bounded cell projection [inference]

glial cell projection

actin-based cell projection [inference]

microvillus

Displaying **all 2** entries
GO Term	Evidence Code	PMID
calcium ion binding	IEA
protein binding	IPI	11927608 15914641 17920587 33758649

GO Hierarchy

molecular function

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Notch

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
calcium ion binding

Displaying **all 4** entries
InterPro
EGF-like calcium-binding domain
EGF-like calcium-binding, conserved site
EGF-like domain
EGF-type aspartate/asparagine hydroxylation site

Disease

Disease Ontology

Displaying **all 6** entries
DO ID	Disease Name	Source
DOID:0050572	cone-rod dystrophy	Alliance of Genome Resources
DOID:0110079	Leber congenital amaurosis 8	Alliance of Genome Resources
DOID:0110358	retinitis pigmentosa 12	Alliance of Genome Resources
DOID:0111541	pigmented paravenous chorioretinal atrophy	Alliance of Genome Resources
DOID:10584	retinitis pigmentosa	Alliance of Genome Resources
DOID:14791	Leber congenital amaurosis	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of 56 in total

« First

‹ Prev

1

2

3

4

5

6

Next ›

Last »
Species	Gene ID	Orthologous MAtrix
Macaca mulatta	710991	MACMU24772
Ornithorhynchus anatinus	100074591	ORNAN20225
Taeniopygia guttata	100223846	TAEGU28976
Callithrix jacchus	100385306	CALJA17680
Pongo abelii	100448356	PONAB18657
Ailuropoda melanoleuca	100484937	AILME12723
Nomascus leucogenys	100601606	NOMLE37578
Cricetulus griseus	100765149	CRIGR13076
Otolemur garnettii	100946002	OTOGA10027
Pan paniscus	100994311	PANPA03389

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements