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folate hydrolase 1

Summary

Gene Symbol

FOLH1

Organism

Homo sapiens (human)

External Links

NCBI Gene

2346

PubChem

2346

Alliance of Genome Resources

HGNC:3788

Annotation

Keyword

3D-structure
Alternative splicing
Calcium
Carboxypeptidase
Cell membrane
Cytoplasm
Dipeptidase
Direct protein sequencing
Glycoprotein
Metal-binding
Metalloprotease
Multifunctional enzyme
Phosphoprotein
Reference proteome
Signal-anchor
Transmembrane helix
Zinc

Proteins

Displaying 1 entry
UniProt	Protein Name
Q04609	Cell growth-inhibiting gene 27 protein Folate hydrolase 1 Folylpoly-gamma-glutamate carboxypeptidase Glutamate carboxypeptidase II Membrane glutamate carboxypeptidase N-acetylated-alpha-linked acidic dipeptidase I Prostate-specific membrane antigen Pteroylpoly-gamma-glutamate carboxypeptidase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
proteolysis	NAS
proteolysis	IDA	12949938
folic acid-containing compound metabolic process	IEA
C-terminal protein deglutamylation	IDA	12949938 17241121 24863754

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

cellular modified amino acid metabolic process [inference]

folic acid-containing compound metabolic process

protein metabolic process [inference]

proteolysis

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-glutamic acid modification [inference]

protein deglutamylation [inference]

C-terminal protein deglutamylation

post-translational protein modification [inference]

C-terminal protein amino acid modification [inference]

C-terminal protein deglutamylation

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process

cellular metabolic process [inference]

cellular modified amino acid metabolic process [inference]

folic acid-containing compound metabolic process

cellular aromatic compound metabolic process [inference]

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process

heterocycle metabolic process [inference]

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-glutamic acid modification [inference]

protein deglutamylation [inference]

C-terminal protein deglutamylation

post-translational protein modification [inference]

C-terminal protein amino acid modification [inference]

C-terminal protein deglutamylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-glutamic acid modification [inference]

protein deglutamylation [inference]

C-terminal protein deglutamylation

post-translational protein modification [inference]

C-terminal protein amino acid modification [inference]

C-terminal protein deglutamylation

macromolecule modification [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-glutamic acid modification [inference]

protein deglutamylation [inference]

C-terminal protein deglutamylation

post-translational protein modification [inference]

C-terminal protein amino acid modification [inference]

C-terminal protein deglutamylation

organic cyclic compound metabolic process [inference]

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process

organonitrogen compound metabolic process [inference]

cellular modified amino acid metabolic process [inference]

folic acid-containing compound metabolic process

protein metabolic process [inference]

proteolysis

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-glutamic acid modification [inference]

protein deglutamylation [inference]

C-terminal protein deglutamylation

post-translational protein modification [inference]

C-terminal protein amino acid modification [inference]

C-terminal protein deglutamylation

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular modified amino acid metabolic process [inference]

folic acid-containing compound metabolic process

cellular aromatic compound metabolic process [inference]

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process

heterocycle metabolic process [inference]

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
cytoplasm	IEA
plasma membrane	TAS
plasma membrane	IDA	12949938
plasma membrane	IBA
cell surface	IDA	12949938

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
carboxypeptidase activity	IBA
metallocarboxypeptidase activity	IDA	12949938 17241121 24863754
protein binding	IPI	32296183
peptidase activity	NAS
dipeptidase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity

metallopeptidase activity [inference]

metalloexopeptidase activity [inference]

metallocarboxypeptidase activity

exopeptidase activity [inference]

carboxypeptidase activity

metallocarboxypeptidase activity

metalloexopeptidase activity [inference]

metallocarboxypeptidase activity

dipeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity

metallopeptidase activity [inference]

metalloexopeptidase activity [inference]

metallocarboxypeptidase activity

exopeptidase activity [inference]

carboxypeptidase activity

metallocarboxypeptidase activity

metalloexopeptidase activity [inference]

metallocarboxypeptidase activity

dipeptidase activity

binding [inference]

protein binding

amide binding [inference]

peptide binding [inference]

oligopeptide binding [inference]

Ac-Asp-Glu binding

ion binding [inference]

anion binding [inference]

Ac-Asp-Glu binding

cation binding [inference]

metal ion binding

tetrahydrofolyl-poly(glutamate) polymer binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying 1 entry
Gene Ontology
carboxypeptidase activity

Displaying **all 6** entries
InterPro
PA domain superfamily
PA domain
Peptidase M28
Transferrin receptor protein 1/Glutamate carboxypeptidase 2-like
Transferrin receptor-like, dimerisation domain superfamily
Transferrin receptor-like, dimerisation domain

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:3526	cerebral infarction	Alliance of Genome Resources
DOID:7693	abdominal aortic aneurysm	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of 86 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Danio rerio	180386	ZFIN:ZDB-GENE-040426-1025
Saccharomyces cerevisiae S288C	288562	SGD:S000003887
Saccharomyces cerevisiae S288C	381204	SGD:S000003887
Danio rerio	393247		DANRE09605
Sus scrofa	397677		PIGXX35163
Pan troglodytes	451185		PANTR04036
Pan troglodytes	451475		PANTR04036
Canis lupus familiaris	476775		CANLF08190
Bos taurus	505865		BOVIN22801
Macaca mulatta	707714		MACMU09417

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OrthoDB (Group)

International Collaboration

Acknowledgements