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folate hydrolase 1

Summary

Gene Symbol

FOLH1

Organism

Homo sapiens (human)

External Links

NCBI Gene

2346

PubChem

2346

Alliance of Genome Resources

HGNC:3788

Annotation

Keyword

3D-structure
Alternative splicing
Calcium
Carboxypeptidase
Cell membrane
Cytoplasm
Dipeptidase
Direct protein sequencing
Glycoprotein
Metal-binding
Metalloprotease
Multifunctional enzyme
Phosphoprotein
Reference proteome
Signal-anchor
Transmembrane helix
Zinc

Proteins

Displaying 1 entry
UniProt	Protein Name
Q04609	Cell growth-inhibiting gene 27 protein Folate hydrolase 1 Folylpoly-gamma-glutamate carboxypeptidase Glutamate carboxypeptidase II Membrane glutamate carboxypeptidase N-acetylated-alpha-linked acidic dipeptidase I Prostate-specific membrane antigen Pteroylpoly-gamma-glutamate carboxypeptidase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
proteolysis	NAS
proteolysis	IDA	12949938
folic acid-containing compound metabolic process	IEA
C-terminal protein deglutamylation	IDA	12949938 17241121 24863754

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

cellular modified amino acid metabolic process [inference]

folic acid-containing compound metabolic process

protein metabolic process [inference]

proteolysis

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-glutamic acid modification [inference]

protein deglutamylation [inference]

C-terminal protein deglutamylation

post-translational protein modification [inference]

C-terminal protein amino acid modification [inference]

C-terminal protein deglutamylation

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process

cellular metabolic process [inference]

cellular modified amino acid metabolic process [inference]

folic acid-containing compound metabolic process

cellular aromatic compound metabolic process [inference]

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process

heterocycle metabolic process [inference]

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-glutamic acid modification [inference]

protein deglutamylation [inference]

C-terminal protein deglutamylation

post-translational protein modification [inference]

C-terminal protein amino acid modification [inference]

C-terminal protein deglutamylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-glutamic acid modification [inference]

protein deglutamylation [inference]

C-terminal protein deglutamylation

post-translational protein modification [inference]

C-terminal protein amino acid modification [inference]

C-terminal protein deglutamylation

macromolecule modification [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-glutamic acid modification [inference]

protein deglutamylation [inference]

C-terminal protein deglutamylation

post-translational protein modification [inference]

C-terminal protein amino acid modification [inference]

C-terminal protein deglutamylation

organic cyclic compound metabolic process [inference]

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process

organonitrogen compound metabolic process [inference]

cellular modified amino acid metabolic process [inference]

folic acid-containing compound metabolic process

protein metabolic process [inference]

proteolysis

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-glutamic acid modification [inference]

protein deglutamylation [inference]

C-terminal protein deglutamylation

post-translational protein modification [inference]

C-terminal protein amino acid modification [inference]

C-terminal protein deglutamylation

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular modified amino acid metabolic process [inference]

folic acid-containing compound metabolic process

cellular aromatic compound metabolic process [inference]

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process

heterocycle metabolic process [inference]

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
cytoplasm	IEA
plasma membrane	TAS
plasma membrane	IDA	12949938
plasma membrane	IBA
cell surface	IDA	12949938

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
carboxypeptidase activity	IBA
metallocarboxypeptidase activity	IDA	12949938 17241121 24863754
protein binding	IPI	32296183
peptidase activity	NAS
dipeptidase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity

metallopeptidase activity [inference]

metalloexopeptidase activity [inference]

metallocarboxypeptidase activity

exopeptidase activity [inference]

carboxypeptidase activity

metallocarboxypeptidase activity

metalloexopeptidase activity [inference]

metallocarboxypeptidase activity

dipeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity

metallopeptidase activity [inference]

metalloexopeptidase activity [inference]

metallocarboxypeptidase activity

exopeptidase activity [inference]

carboxypeptidase activity

metallocarboxypeptidase activity

metalloexopeptidase activity [inference]

metallocarboxypeptidase activity

dipeptidase activity

binding [inference]

protein binding

amide binding [inference]

peptide binding [inference]

oligopeptide binding [inference]

Ac-Asp-Glu binding

ion binding [inference]

anion binding [inference]

Ac-Asp-Glu binding

cation binding [inference]

metal ion binding

tetrahydrofolyl-poly(glutamate) polymer binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying 1 entry
Gene Ontology
carboxypeptidase activity

Displaying **all 6** entries
InterPro
PA domain superfamily
PA domain
Peptidase M28
Transferrin receptor protein 1/Glutamate carboxypeptidase 2-like
Transferrin receptor-like, dimerisation domain superfamily
Transferrin receptor-like, dimerisation domain

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:3526	cerebral infarction	Alliance of Genome Resources
DOID:7693	abdominal aortic aneurysm	Alliance of Genome Resources

Ortholog

Displaying entries **31 - 40** of 86 in total

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Species	Gene ID	Orthologous MAtrix
Pongo abelii	100453848	PONAB04425
Ailuropoda melanoleuca	100472805	AILME03927
Anolis carolinensis	100551729	ANOCA05240
Nomascus leucogenys	100589099	NOMLE10691
Loxodonta africana	100660135	LOXAF05773
Oreochromis niloticus	100702164	ORENI16934
Cavia porcellus	100712916	CAVPO15481
Cricetulus griseus	100768684	CRIGR25876
Sarcophilus harrisii	100918727	SARHA11163
Otolemur garnettii	100962089	OTOGA18918

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OrthoDB (Group)

International Collaboration

Acknowledgements