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MIRAGE

nucleoporin 188

Summary

Gene Symbol

NUP188

Organism

Homo sapiens (human)

External Links

NCBI Gene

23511

PubChem

23511

Alliance of Genome Resources

HGNC:17859

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Cataract
Disease variant
Microphthalmia
Nuclear pore complex
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q5SRE5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
RNA export from nucleus	IBA
protein import into nucleus	IMP	32275884
protein import into nucleus	IBA
nucleocytoplasmic transport	NAS	27016207
mRNA transport	IEA

GO Hierarchy

biological process

cellular process [inference]

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus

nuclear transport [inference]

nucleocytoplasmic transport

nuclear export [inference]

RNA export from nucleus

import into nucleus [inference]

protein import into nucleus

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to nucleus [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to nucleus [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus

nuclear transport [inference]

nucleocytoplasmic transport

nuclear export [inference]

RNA export from nucleus

import into nucleus [inference]

protein import into nucleus

organic substance transport [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

nucleobase-containing compound transport [inference]

nucleic acid transport [inference]

RNA transport [inference]

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

nucleobase-containing compound transport [inference]

nucleic acid transport [inference]

RNA transport [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

establishment of RNA localization [inference]

RNA transport [inference]

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus

nuclear transport [inference]

nucleocytoplasmic transport

nuclear export [inference]

RNA export from nucleus

import into nucleus [inference]

protein import into nucleus

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus

nuclear transport [inference]

nucleocytoplasmic transport

nuclear export [inference]

RNA export from nucleus

import into nucleus [inference]

protein import into nucleus

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to nucleus [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
nuclear envelope	TAS
nuclear envelope	IDA	24315095
nuclear pore	NAS	24315095
cytosol	TAS
membrane	HDA	19946888

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

cellular anatomical entity [inference]

envelope [inference]

organelle envelope [inference]

nuclear envelope

Displaying 1 entry
GO Term	Evidence Code	PMID
structural constituent of nuclear pore	IBA

GO Hierarchy

molecular function

structural molecule activity [inference]

structural constituent of nuclear pore

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Nucleoporin

Functional Category

I: Lipid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
RNA export from nucleus
mRNA transport
protein import into nucleus

Displaying **all 3** entries
InterPro
Nucleoporin Nup188, N-terminal subdomain III
Nucleoporin Nup188, N-terminal
Nucleoporin Nup188

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0081272	Sandestig-Stefanova syndrome	Alliance of Genome Resources
DOID:11162	respiratory failure	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 82 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	23511	Xenbase:XB-GENE-5933085
Mus musculus	227699	Xenbase:XB-GENE-5933085	MOUSE33033
Rattus norvegicus	366016		RATNO27705
Pan troglodytes	464912		PANTR48449
Canis lupus familiaris	491307		CANLF19381
Bos taurus	504307		BOVIN03266
Danio rerio	559225		DANRE21958
Macaca mulatta	722580		MACMU11915
Monodelphis domestica	100012310		MONDO03952
Equus caballus	100070114		HORSE23658

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Last updated: April 7, 2025