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solute carrier family 7 member 11

Summary

Gene Symbol

SLC7A11

Organism

Homo sapiens (human)

External Links

NCBI Gene

23657

PubChem

23657

Alliance of Genome Resources

HGNC:11059

Annotation

Keyword

3D-structure
Amino-acid transport
Cell membrane
Cell projection
Disulfide bond
Glycoprotein
Lysosome
Phosphoprotein
Proteomics identification
Reference proteome
Transmembrane helix
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9UPY5	Amino acid transport system xc- Calcium channel blocker resistance protein CCBR1 Solute carrier family 7 member 11 xCT

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 34 in total

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GO Term	Evidence Code	PMID
amino acid transmembrane transport	IBA
glutathione metabolic process	IEA
visual learning	IEA
response to toxic substance	IDA	17575980
response to organic cyclic compound

GO Hierarchy

biological process

metabolic process [inference]

organic substance metabolic process [inference]

glutathione metabolic process

cellular process [inference]

cell adhesion [inference]

cell-cell adhesion [inference]

homotypic cell-cell adhesion [inference]

platelet aggregation

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation [inference]

lens fiber cell differentiation

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

transmembrane transport [inference]

glutathione transmembrane transport

oligopeptide transmembrane transport [inference]

dipeptide transmembrane transport [inference]

dipeptide import across plasma membrane

oligopeptide import across plasma membrane [inference]

dipeptide import across plasma membrane

import across plasma membrane [inference]

amino acid import across plasma membrane [inference]

L-glutamate import across plasma membrane

oligopeptide import across plasma membrane [inference]

dipeptide import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport

amino acid import across plasma membrane [inference]

L-glutamate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-kynurenine transmembrane transport

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory [inference]

learning [inference]

associative learning [inference]

visual learning

behavior [inference]

learning or memory [inference]

learning [inference]

associative learning [inference]

visual learning

visual behavior [inference]

visual learning

adult behavior

developmental process [inference]

anatomical structure development [inference]

system development [inference]

ventricular system development

appendage development [inference]

limb development

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation [inference]

lens fiber cell differentiation

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular amino acid homeostasis [inference]

intracellular glutamate homeostasis

chemical homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular amino acid homeostasis [inference]

intracellular glutamate homeostasis

response to stimulus [inference]

response to stress [inference]

response to oxidative stress [inference]

cellular response to oxidative stress

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus [inference]

visual behavior [inference]

visual learning

response to chemical [inference]

response to toxic substance

response to organic substance [inference]

response to organic cyclic compound

response to nicotine

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

response to redox state

localization [inference]

establishment of localization [inference]

transport [inference]

transmembrane transport [inference]

glutathione transmembrane transport

oligopeptide transmembrane transport [inference]

dipeptide transmembrane transport [inference]

dipeptide import across plasma membrane

oligopeptide import across plasma membrane [inference]

dipeptide import across plasma membrane

import across plasma membrane [inference]

amino acid import across plasma membrane [inference]

L-glutamate import across plasma membrane

oligopeptide import across plasma membrane [inference]

dipeptide import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport

amino acid import across plasma membrane [inference]

L-glutamate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-kynurenine transmembrane transport

organic substance transport [inference]

organic anion transport [inference]

glutathione transport [inference]

glutathione transmembrane transport

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

amino acid transport [inference]

sulfur amino acid transport [inference]

L-cystine transport

amino acid transmembrane transport

amino acid import across plasma membrane [inference]

L-glutamate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-kynurenine transmembrane transport

acidic amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

neutral amino acid transport [inference]

L-cystine transport

L-amino acid transport [inference]

L-cystine transport

L-glutamate import [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-kynurenine transmembrane transport

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport

amino acid import across plasma membrane [inference]

L-glutamate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-kynurenine transmembrane transport

peptide transport [inference]

oligopeptide transport [inference]

oligopeptide transmembrane transport [inference]

dipeptide transmembrane transport [inference]

dipeptide import across plasma membrane

oligopeptide import across plasma membrane [inference]

dipeptide import across plasma membrane

dipeptide transport [inference]

dipeptide transmembrane transport [inference]

dipeptide import across plasma membrane

organic acid transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

amino acid transport [inference]

sulfur amino acid transport [inference]

L-cystine transport

amino acid transmembrane transport

amino acid import across plasma membrane [inference]

L-glutamate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-kynurenine transmembrane transport

acidic amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

neutral amino acid transport [inference]

L-cystine transport

L-amino acid transport [inference]

L-cystine transport

L-glutamate import [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-kynurenine transmembrane transport

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport

amino acid import across plasma membrane [inference]

L-glutamate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-kynurenine transmembrane transport

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport

amino acid import across plasma membrane [inference]

L-glutamate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-kynurenine transmembrane transport

modified amino acid transport [inference]

L-cystine transport

nitrogen compound transport [inference]

amino acid transport [inference]

sulfur amino acid transport [inference]

L-cystine transport

amino acid transmembrane transport

amino acid import across plasma membrane [inference]

L-glutamate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-kynurenine transmembrane transport

acidic amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

neutral amino acid transport [inference]

L-cystine transport

L-amino acid transport [inference]

L-cystine transport

L-glutamate import [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-kynurenine transmembrane transport

amide transport [inference]

peptide transport [inference]

oligopeptide transport [inference]

oligopeptide transmembrane transport [inference]

dipeptide transmembrane transport [inference]

dipeptide import across plasma membrane

oligopeptide import across plasma membrane [inference]

dipeptide import across plasma membrane

dipeptide transport [inference]

dipeptide transmembrane transport [inference]

dipeptide import across plasma membrane

L-glutamate import [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

modified amino acid transport [inference]

L-cystine transport

sulfur compound transport [inference]

sulfur amino acid transport [inference]

L-cystine transport

import into cell [inference]

amino acid import across plasma membrane [inference]

L-glutamate import across plasma membrane

oligopeptide import across plasma membrane [inference]

dipeptide import across plasma membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of neutrophil apoptotic process

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of secondary metabolite biosynthetic process [inference]

regulation of melanin biosynthetic process

regulation of cellular metabolic process [inference]

regulation of cellular ketone metabolic process [inference]

regulation of cellular amino acid metabolic process [inference]

regulation of glutamine family amino acid metabolic process [inference]

regulation of glutamate metabolic process

regulation of cysteine metabolic process

regulation of cellular biosynthetic process [inference]

regulation of sulfur metabolic process [inference]

regulation of sulfur amino acid metabolic process [inference]

regulation of cysteine metabolic process

regulation of secondary metabolic process [inference]

regulation of secondary metabolite biosynthetic process [inference]

regulation of melanin biosynthetic process

regulation of nitrogen compound metabolic process [inference]

regulation of sulfur amino acid metabolic process [inference]

regulation of cysteine metabolic process

regulation of amine metabolic process [inference]

regulation of cellular amino acid metabolic process [inference]

regulation of glutamine family amino acid metabolic process [inference]

regulation of glutamate metabolic process

regulation of cysteine metabolic process

regulation of amide metabolic process [inference]

regulation of small molecule metabolic process [inference]

regulation of cellular ketone metabolic process [inference]

regulation of cellular amino acid metabolic process [inference]

regulation of glutamine family amino acid metabolic process [inference]

regulation of glutamate metabolic process

regulation of cysteine metabolic process

regulation of sulfur amino acid metabolic process [inference]

regulation of cysteine metabolic process

regulation of primary metabolic process [inference]

regulation of cellular amino acid metabolic process [inference]

regulation of glutamine family amino acid metabolic process [inference]

regulation of glutamate metabolic process

regulation of cysteine metabolic process

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

regulation of localization [inference]

regulation of transport [inference]

regulation of protein transport

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport

regulation of protein localization to membrane [inference]

regulation of receptor clustering [inference]

regulation of glutamate receptor clustering [inference]

regulation of AMPA glutamate receptor clustering

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of ferroptosis

regulation of response to stimulus [inference]

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of cellular response to oxidative stress

regulation of response to oxidative stress [inference]

regulation of cellular response to oxidative stress

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

regulation of cellular metabolic process [inference]

regulation of cellular ketone metabolic process [inference]

regulation of cellular amino acid metabolic process [inference]

regulation of glutamine family amino acid metabolic process [inference]

regulation of glutamate metabolic process

regulation of cysteine metabolic process

regulation of cellular biosynthetic process [inference]

regulation of sulfur metabolic process [inference]

regulation of sulfur amino acid metabolic process [inference]

regulation of cysteine metabolic process

regulation of cell population proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

regulation of myeloid cell apoptotic process [inference]

regulation of neutrophil apoptotic process

regulation of leukocyte apoptotic process [inference]

regulation of neutrophil apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of ferroptosis

regulation of ferroptosis [inference]

negative regulation of ferroptosis

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of ferroptosis

regulation of cellular component organization [inference]

regulation of synapse organization

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport

regulation of protein localization to membrane [inference]

regulation of receptor clustering [inference]

regulation of glutamate receptor clustering [inference]

regulation of AMPA glutamate receptor clustering

regulation of cellular response to stress [inference]

regulation of cellular response to oxidative stress

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
plasma membrane	TAS
plasma membrane	IDA	11417227 15151999
plasma membrane	IPI	34880232
cell surface	IDA	25063885
membrane	TAS	10206947

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cell surface

membrane

plasma membrane

plasma membrane region [inference]

cell projection membrane [inference]

cell projection [inference]

plasma membrane bounded cell projection [inference]

glial cell projection [inference]

astrocyte projection

apical part of cell

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	21397861 32296183 34880232
L-amino acid transmembrane transporter activity	IBA
cystine:glutamate antiporter activity	RCA	34880232
cystine:glutamate antiporter activity	IDA	11417227 15151999 34120018 35245456 35352032
L-kynurenine transmembrane transporter activity	IDA	35245456