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solute carrier family 7 member 11

Summary

Gene Symbol

SLC7A11

Organism

Homo sapiens (human)

External Links

NCBI Gene

23657

PubChem

23657

Alliance of Genome Resources

HGNC:11059

JoGo

SLC7A11

TogoVar

SLC7A11

Annotation

Keyword

3D-structure
Amino-acid transport
Cell membrane
Cell projection
Disulfide bond
Glycoprotein
Lysosome
Phosphoprotein
Proteomics identification
Reference proteome
Transmembrane helix
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9UPY5	Amino acid transport system xc- Calcium channel blocker resistance protein CCBR1 Solute carrier family 7 member 11 xCT

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 34 in total

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GO Term	Evidence Code	PMID
L-cystine transport	IDA	11133847 11213471 11417227 15151999 34880232 35352032
L-glutamate transmembrane transport	IDA	11133847 11417227 15151999 34880232 35352032
ventricular system development	IEA
striatum development	IEA
adult behavior	IEA

GO Hierarchy

biological process

metabolic process [inference]

organic substance metabolic process [inference]

glutathione metabolic process

cellular process [inference]

cell adhesion [inference]

cell-cell adhesion [inference]

homotypic cell-cell adhesion [inference]

platelet aggregation

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation [inference]

lens fiber cell differentiation

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

transmembrane transport [inference]

glutathione transmembrane transport

oligopeptide transmembrane transport [inference]

dipeptide transmembrane transport [inference]

dipeptide import across plasma membrane

oligopeptide import across plasma membrane [inference]

dipeptide import across plasma membrane

import across plasma membrane [inference]

amino acid import across plasma membrane [inference]

L-glutamate import across plasma membrane

oligopeptide import across plasma membrane [inference]

dipeptide import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport

amino acid import across plasma membrane [inference]

L-glutamate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-kynurenine transmembrane transport

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory [inference]

learning [inference]

associative learning [inference]

visual learning

behavior [inference]

learning or memory [inference]

learning [inference]

associative learning [inference]

visual learning

visual behavior [inference]

visual learning

adult behavior

developmental process [inference]

anatomical structure development [inference]

system development [inference]

ventricular system development

appendage development [inference]

limb development

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation [inference]

lens fiber cell differentiation

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular amino acid homeostasis [inference]

intracellular glutamate homeostasis

chemical homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular amino acid homeostasis [inference]

intracellular glutamate homeostasis

response to stimulus [inference]

response to stress [inference]

response to oxidative stress [inference]

cellular response to oxidative stress

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus [inference]

visual behavior [inference]

visual learning

response to chemical [inference]

response to toxic substance

response to organic substance [inference]

response to organic cyclic compound

response to nicotine

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

response to redox state

localization [inference]

establishment of localization [inference]

transport [inference]

transmembrane transport [inference]

glutathione transmembrane transport

oligopeptide transmembrane transport [inference]

dipeptide transmembrane transport [inference]

dipeptide import across plasma membrane

oligopeptide import across plasma membrane [inference]

dipeptide import across plasma membrane

import across plasma membrane [inference]

amino acid import across plasma membrane [inference]

L-glutamate import across plasma membrane

oligopeptide import across plasma membrane [inference]

dipeptide import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport

amino acid import across plasma membrane [inference]

L-glutamate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-kynurenine transmembrane transport

organic substance transport [inference]

organic anion transport [inference]

glutathione transport [inference]

glutathione transmembrane transport

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

amino acid transport [inference]

sulfur amino acid transport [inference]

L-cystine transport

amino acid transmembrane transport

amino acid import across plasma membrane [inference]

L-glutamate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-kynurenine transmembrane transport

acidic amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

neutral amino acid transport [inference]

L-cystine transport

L-amino acid transport [inference]

L-cystine transport

L-glutamate import [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-kynurenine transmembrane transport

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport

amino acid import across plasma membrane [inference]

L-glutamate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-kynurenine transmembrane transport

peptide transport [inference]

oligopeptide transport [inference]

oligopeptide transmembrane transport [inference]

dipeptide transmembrane transport [inference]

dipeptide import across plasma membrane

oligopeptide import across plasma membrane [inference]

dipeptide import across plasma membrane

dipeptide transport [inference]

dipeptide transmembrane transport [inference]

dipeptide import across plasma membrane

organic acid transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

amino acid transport [inference]

sulfur amino acid transport [inference]

L-cystine transport

amino acid transmembrane transport

amino acid import across plasma membrane [inference]

L-glutamate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-kynurenine transmembrane transport

acidic amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

neutral amino acid transport [inference]

L-cystine transport

L-amino acid transport [inference]

L-cystine transport

L-glutamate import [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-kynurenine transmembrane transport

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport

amino acid import across plasma membrane [inference]

L-glutamate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-kynurenine transmembrane transport

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport

amino acid import across plasma membrane [inference]

L-glutamate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-kynurenine transmembrane transport

modified amino acid transport [inference]

L-cystine transport

nitrogen compound transport [inference]

amino acid transport [inference]

sulfur amino acid transport [inference]

L-cystine transport

amino acid transmembrane transport

amino acid import across plasma membrane [inference]

L-glutamate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-kynurenine transmembrane transport

acidic amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

neutral amino acid transport [inference]

L-cystine transport

L-amino acid transport [inference]

L-cystine transport

L-glutamate import [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-kynurenine transmembrane transport

amide transport [inference]

peptide transport [inference]

oligopeptide transport [inference]

oligopeptide transmembrane transport [inference]

dipeptide transmembrane transport [inference]

dipeptide import across plasma membrane

oligopeptide import across plasma membrane [inference]

dipeptide import across plasma membrane

dipeptide transport [inference]

dipeptide transmembrane transport [inference]

dipeptide import across plasma membrane

L-glutamate import [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

modified amino acid transport [inference]

L-cystine transport

sulfur compound transport [inference]

sulfur amino acid transport [inference]

L-cystine transport

import into cell [inference]

amino acid import across plasma membrane [inference]

L-glutamate import across plasma membrane

oligopeptide import across plasma membrane [inference]

dipeptide import across plasma membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of neutrophil apoptotic process

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of secondary metabolite biosynthetic process [inference]

regulation of melanin biosynthetic process

regulation of cellular metabolic process [inference]

regulation of cellular ketone metabolic process [inference]

regulation of cellular amino acid metabolic process [inference]

regulation of glutamine family amino acid metabolic process [inference]

regulation of glutamate metabolic process

regulation of cysteine metabolic process

regulation of cellular biosynthetic process [inference]

regulation of sulfur metabolic process [inference]

regulation of sulfur amino acid metabolic process [inference]

regulation of cysteine metabolic process

regulation of secondary metabolic process [inference]

regulation of secondary metabolite biosynthetic process [inference]

regulation of melanin biosynthetic process

regulation of nitrogen compound metabolic process [inference]

regulation of sulfur amino acid metabolic process [inference]

regulation of cysteine metabolic process

regulation of amine metabolic process [inference]

regulation of cellular amino acid metabolic process [inference]

regulation of glutamine family amino acid metabolic process [inference]

regulation of glutamate metabolic process

regulation of cysteine metabolic process

regulation of amide metabolic process [inference]

regulation of small molecule metabolic process [inference]

regulation of cellular ketone metabolic process [inference]

regulation of cellular amino acid metabolic process [inference]

regulation of glutamine family amino acid metabolic process [inference]

regulation of glutamate metabolic process

regulation of cysteine metabolic process

regulation of sulfur amino acid metabolic process [inference]

regulation of cysteine metabolic process

regulation of primary metabolic process [inference]

regulation of cellular amino acid metabolic process [inference]

regulation of glutamine family amino acid metabolic process [inference]

regulation of glutamate metabolic process

regulation of cysteine metabolic process

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

regulation of localization [inference]

regulation of transport [inference]

regulation of protein transport

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport

regulation of protein localization to membrane [inference]

regulation of receptor clustering [inference]

regulation of glutamate receptor clustering [inference]

regulation of AMPA glutamate receptor clustering

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of ferroptosis

regulation of response to stimulus [inference]

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of cellular response to oxidative stress

regulation of response to oxidative stress [inference]

regulation of cellular response to oxidative stress

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

regulation of cellular metabolic process [inference]

regulation of cellular ketone metabolic process [inference]

regulation of cellular amino acid metabolic process [inference]

regulation of glutamine family amino acid metabolic process [inference]

regulation of glutamate metabolic process

regulation of cysteine metabolic process

regulation of cellular biosynthetic process [inference]

regulation of sulfur metabolic process [inference]

regulation of sulfur amino acid metabolic process [inference]

regulation of cysteine metabolic process

regulation of cell population proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

regulation of myeloid cell apoptotic process [inference]

regulation of neutrophil apoptotic process

regulation of leukocyte apoptotic process [inference]

regulation of neutrophil apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of ferroptosis

regulation of ferroptosis [inference]

negative regulation of ferroptosis

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of ferroptosis

regulation of cellular component organization [inference]

regulation of synapse organization

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport

regulation of protein localization to membrane [inference]

regulation of receptor clustering [inference]

regulation of glutamate receptor clustering [inference]

regulation of AMPA glutamate receptor clustering

regulation of cellular response to stress [inference]

regulation of cellular response to oxidative stress

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
plasma membrane	TAS
plasma membrane	IDA	11417227 15151999
plasma membrane	IPI	34880232
cell surface	IDA	25063885
membrane	TAS	10206947

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cell surface

membrane

plasma membrane

plasma membrane region [inference]

cell projection membrane [inference]

cell projection [inference]

plasma membrane bounded cell projection [inference]

glial cell projection [inference]

astrocyte projection

apical part of cell

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	21397861 32296183 34880232
L-amino acid transmembrane transporter activity	IBA
cystine:glutamate antiporter activity	RCA	34880232
cystine:glutamate antiporter activity	IDA	11417227 15151999 34120018 35245456 35352032
L-kynurenine transmembrane transporter activity	IDA	35245456