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Repository for lectin-assisted multimodality data

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Guidelines

MIRAGE

catechol-O-methyltransferase

Summary

Gene Symbol

Comt

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

24267

PubChem

24267

Alliance of Genome Resources

RGD:2379

Annotation

Keyword

3D-structure
Alternative initiation
Catecholamine metabolism
Cell membrane
Cytoplasm
Lipid metabolism
Magnesium
Metal-binding
Methyltransferase
Neurotransmitter degradation
Phosphoprotein
Proteomics identification
Reference proteome
S-adenosyl-L-methionine
Signal-anchor
Transmembrane helix

Proteins

Displaying **all 4** entries
UniProt	Protein Name
A0A8I6A1I0
P22734
F2W8B1
F2W8B0

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 80 in total

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GO Term	Evidence Code	PMID
behavioral fear response	ISO
response to hypoxia	ISO
kidney development	ISO
synaptic transmission, dopaminergic	ISO
startle response	ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

S-adenosylhomocysteine metabolic process

cellular modified amino acid metabolic process [inference]

S-adenosylhomocysteine metabolic process

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

amine metabolic process [inference]

biogenic amine metabolic process [inference]

catecholamine metabolic process

norepinephrine metabolic process

dopamine metabolic process

dopamine catabolic process

catecholamine catabolic process

dopamine catabolic process

amine catabolic process [inference]

cellular biogenic amine catabolic process [inference]

catecholamine catabolic process

dopamine catabolic process

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

protein alkylation [inference]

protein methylation

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

organonitrogen compound catabolic process [inference]

amine catabolic process [inference]

cellular biogenic amine catabolic process [inference]

catecholamine catabolic process

dopamine catabolic process

catabolic process [inference]

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process

dopamine catabolic process

organic substance catabolic process [inference]

organic cyclic compound catabolic process [inference]

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process

dopamine catabolic process

organonitrogen compound catabolic process [inference]

amine catabolic process [inference]

cellular biogenic amine catabolic process [inference]

catecholamine catabolic process

dopamine catabolic process

organic hydroxy compound catabolic process [inference]

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process

dopamine catabolic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

macromolecule methylation [inference]

protein methylation

hormone metabolic process [inference]

estrogen metabolic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

S-adenosylhomocysteine metabolic process

icosanoid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

unsaturated fatty acid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

energy reserve metabolic process [inference]

glycogen metabolic process

cellular modified amino acid metabolic process [inference]

S-adenosylhomocysteine metabolic process

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

phenol-containing compound metabolic process [inference]

catechol-containing compound metabolic process [inference]

catecholamine metabolic process

norepinephrine metabolic process

dopamine metabolic process

dopamine catabolic process

catecholamine catabolic process

dopamine catabolic process

catechol-containing compound catabolic process [inference]

catecholamine catabolic process

dopamine catabolic process

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process

dopamine catabolic process

aromatic compound catabolic process [inference]

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process

dopamine catabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

sulfur compound metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process

dopamine catabolic process

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

unsaturated fatty acid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

polysaccharide metabolic process [inference]

glucan metabolic process [inference]

glycogen metabolic process

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

S-adenosylhomocysteine metabolic process

lipid metabolic process [inference]

steroid metabolic process [inference]

estrogen metabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

unsaturated fatty acid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

protein alkylation [inference]

protein methylation

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

S-adenosylhomocysteine metabolic process

icosanoid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

unsaturated fatty acid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

polysaccharide metabolic process [inference]

glucan metabolic process [inference]

glycogen metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

S-adenosylhomocysteine metabolic process

icosanoid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

unsaturated fatty acid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

lipid metabolic process [inference]

steroid metabolic process [inference]

estrogen metabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

unsaturated fatty acid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

macromolecule metabolic process [inference]

polysaccharide metabolic process [inference]

glucan metabolic process [inference]

glycogen metabolic process

macromolecule biosynthetic process [inference]

gene expression

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

protein alkylation [inference]

protein methylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation

protein alkylation [inference]

protein methylation

macromolecule methylation [inference]

protein methylation

S-adenosylmethionine metabolic process

carbohydrate derivative metabolic process [inference]

glycosyl compound metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

steroid metabolic process [inference]

estrogen metabolic process

phenol-containing compound metabolic process [inference]

catechol-containing compound metabolic process [inference]

catecholamine metabolic process

norepinephrine metabolic process

dopamine metabolic process

dopamine catabolic process

catecholamine catabolic process

dopamine catabolic process

catechol-containing compound catabolic process [inference]

catecholamine catabolic process

dopamine catabolic process

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process

dopamine catabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

organic cyclic compound catabolic process [inference]

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process

dopamine catabolic process

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

S-adenosylhomocysteine metabolic process

cellular modified amino acid metabolic process [inference]

S-adenosylhomocysteine metabolic process

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

amine metabolic process [inference]

biogenic amine metabolic process [inference]

catecholamine metabolic process

norepinephrine metabolic process

dopamine metabolic process

dopamine catabolic process

catecholamine catabolic process

dopamine catabolic process

amine catabolic process [inference]

cellular biogenic amine catabolic process [inference]

catecholamine catabolic process

dopamine catabolic process

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

protein alkylation [inference]

protein methylation

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

organonitrogen compound catabolic process [inference]

amine catabolic process [inference]

cellular biogenic amine catabolic process [inference]

catecholamine catabolic process

dopamine catabolic process

organic substance catabolic process [inference]

organic cyclic compound catabolic process [inference]

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process

dopamine catabolic process

organonitrogen compound catabolic process [inference]

amine catabolic process [inference]

cellular biogenic amine catabolic process [inference]

catecholamine catabolic process

dopamine catabolic process

organic hydroxy compound catabolic process [inference]

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process

dopamine catabolic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic hydroxy compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

catechol-containing compound metabolic process [inference]

catecholamine metabolic process

norepinephrine metabolic process

dopamine metabolic process

dopamine catabolic process

catecholamine catabolic process

dopamine catabolic process

catechol-containing compound catabolic process [inference]

catecholamine catabolic process

dopamine catabolic process

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process

dopamine catabolic process

organic hydroxy compound catabolic process [inference]

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process

dopamine catabolic process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

synaptic transmission, dopaminergic

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to phosphate starvation

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

S-adenosylhomocysteine metabolic process

icosanoid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

unsaturated fatty acid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

energy reserve metabolic process [inference]

glycogen metabolic process

cellular modified amino acid metabolic process [inference]

S-adenosylhomocysteine metabolic process

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

phenol-containing compound metabolic process [inference]

catechol-containing compound metabolic process [inference]

catecholamine metabolic process

norepinephrine metabolic process

dopamine metabolic process

dopamine catabolic process

catecholamine catabolic process

dopamine catabolic process

catechol-containing compound catabolic process [inference]

catecholamine catabolic process

dopamine catabolic process

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process

dopamine catabolic process

aromatic compound catabolic process [inference]

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process

dopamine catabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

sulfur compound metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process

dopamine catabolic process

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

unsaturated fatty acid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

renin secretion into blood stream

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

renin secretion into blood stream

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

renin secretion into blood stream

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to phosphate starvation

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to phosphate starvation

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to cocaine

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to cocaine

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to cocaine

cellular response to oxygen-containing compound [inference]

cellular response to cocaine

cellular response to salt [inference]

cellular response to cocaine

export from cell [inference]

secretion by cell [inference]

protein secretion [inference]

renin secretion into blood stream

signal release [inference]

catecholamine secretion [inference]

reproductive process [inference]

multi-organism reproductive process [inference]

female pregnancy

multicellular organismal process [inference]

system process [inference]

renal system process [inference]

renal absorption [inference]

renal protein absorption [inference]

renal albumin absorption

renal filtration

renal tubular secretion [inference]

renal sodium excretion

excretion [inference]

renal tubular secretion [inference]

renal sodium excretion

digestive system process [inference]

mastication

nervous system process [inference]

learning or memory

associative learning [inference]

visual learning

nonassociative learning [inference]

habituation

short-term memory

neuromuscular process [inference]

startle response

behavior [inference]

behavioral defense response [inference]

behavioral fear response

learning or memory

associative learning [inference]

visual learning

nonassociative learning [inference]

habituation

short-term memory

visual behavior [inference]

visual learning

exploration behavior

multicellular organismal response to stress

behavioral fear response

response to pain

multicellular organism growth

multi-multicellular organism process [inference]

female pregnancy

developmental process

anatomical structure morphogenesis [inference]

cerebellar cortex morphogenesis

anatomical structure development [inference]

blood vessel development [inference]

artery development

glomerulus development

animal organ development [inference]

kidney development

growth [inference]

developmental growth [inference]

multicellular organism growth

response to stimulus [inference]

response to stress

response to hypoxia

defense response [inference]

behavioral defense response [inference]

behavioral fear response

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to phosphate starvation

multicellular organismal response to stress

behavioral fear response

response to pain

response to starvation [inference]

cellular response to starvation [inference]

cellular response to phosphate starvation

response to external stimulus [inference]

startle response

detection of external stimulus [inference]

detection of temperature stimulus [inference]

detection of temperature stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in sensory perception of pain

response to extracellular stimulus [inference]

response to nutrient levels [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to phosphate starvation

response to food

response to starvation [inference]

cellular response to starvation [inference]

cellular response to phosphate starvation

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to phosphate starvation

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

cellular response to external stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to phosphate starvation

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to abiotic stimulus [inference]

response to temperature stimulus

detection of temperature stimulus [inference]

detection of temperature stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in sensory perception of pain

response to radiation [inference]

response to light stimulus [inference]

visual behavior [inference]

visual learning

detection of abiotic stimulus [inference]

detection of temperature stimulus [inference]

detection of temperature stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in sensory perception of pain

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

response to endogenous stimulus [inference]

response to hormone [inference]

response to peptide hormone [inference]

response to angiotensin

response to estrogen

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid [inference]

response to corticosterone

response to mineralocorticoid [inference]

response to corticosterone

cellular response to endogenous stimulus [inference]

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to cocaine

response to chemical [inference]

response to organic substance [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to hormone [inference]

response to peptide hormone [inference]

response to angiotensin

response to estrogen

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid [inference]

response to corticosterone

response to mineralocorticoid [inference]

response to corticosterone

response to organonitrogen compound [inference]

response to amine [inference]

response to amphetamine

response to alkaloid [inference]

response to cocaine [inference]

cellular response to cocaine

cellular response to alkaloid [inference]

cellular response to cocaine

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to cocaine

response to monoamine [inference]

response to catecholamine [inference]

response to dopamine

response to peptide [inference]

response to peptide hormone [inference]

response to angiotensin

response to organic cyclic compound

response to cocaine [inference]

cellular response to cocaine

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid [inference]

response to corticosterone

response to mineralocorticoid [inference]

response to corticosterone

cellular response to organic cyclic compound [inference]

cellular response to cocaine

response to catecholamine [inference]

response to dopamine

response to lipid [inference]

response to lipopolysaccharide

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid [inference]

response to corticosterone

response to mineralocorticoid [inference]

response to corticosterone

response to cytokine

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to cocaine

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to cocaine

response to alcohol [inference]

response to corticosterone

response to ketone [inference]

response to corticosterone

response to food

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to cocaine

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to cocaine

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to cocaine

cellular response to oxygen-containing compound [inference]

cellular response to cocaine

cellular response to salt [inference]

cellular response to cocaine

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to amine [inference]

response to amphetamine

response to alkaloid [inference]

response to cocaine [inference]

cellular response to cocaine

cellular response to alkaloid [inference]

cellular response to cocaine

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to cocaine

response to monoamine [inference]

response to catecholamine [inference]

response to dopamine

response to peptide [inference]

response to peptide hormone [inference]

response to angiotensin

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to cocaine

response to oxygen-containing compound [inference]

response to lipopolysaccharide

response to cocaine [inference]

cellular response to cocaine

response to catecholamine [inference]

response to dopamine

response to alcohol [inference]

response to corticosterone

response to risperidone

response to peptide [inference]

response to peptide hormone [inference]

response to angiotensin

response to ketone [inference]

response to corticosterone

cellular response to oxygen-containing compound [inference]

cellular response to cocaine

response to salt

response to cocaine [inference]

cellular response to cocaine

cellular response to salt [inference]

cellular response to cocaine

detection of stimulus [inference]

detection of external stimulus [inference]

detection of temperature stimulus [inference]

detection of temperature stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in sensory perception of pain

detection of abiotic stimulus [inference]

detection of temperature stimulus [inference]

detection of temperature stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in sensory perception of pain

detection of stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in sensory perception of pain

detection of stimulus involved in sensory perception of pain [inference]

detection of temperature stimulus involved in sensory perception of pain

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to phosphate starvation

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to phosphate starvation

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to cocaine

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to cocaine

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to cocaine

cellular response to oxygen-containing compound [inference]

cellular response to cocaine

cellular response to salt [inference]

cellular response to cocaine

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

renin secretion into blood stream

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

renin secretion into blood stream

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

renin secretion into blood stream

establishment of localization [inference]

transport [inference]

secretion [inference]

secretion by cell [inference]

protein secretion [inference]

renin secretion into blood stream

signal release [inference]

catecholamine secretion [inference]

organic substance transport [inference]

lipid transport [inference]

sterol transport [inference]

cholesterol transport [inference]

cholesterol efflux

protein transport [inference]

protein secretion [inference]

renin secretion into blood stream

organic cation transport [inference]

norepinephrine transport [inference]

norepinephrine secretion

monoamine transport [inference]

catecholamine transport [inference]

dopamine transport [inference]

dopamine secretion

norepinephrine transport [inference]

norepinephrine secretion

catecholamine secretion [inference]

organic hydroxy compound transport [inference]

sterol transport [inference]

cholesterol transport [inference]

cholesterol efflux

catecholamine transport [inference]

dopamine transport [inference]

dopamine secretion

norepinephrine transport [inference]

norepinephrine secretion

catecholamine secretion [inference]

nitrogen compound transport [inference]

protein transport [inference]

protein secretion [inference]

renin secretion into blood stream

monoamine transport [inference]

catecholamine transport [inference]

dopamine transport [inference]

dopamine secretion

norepinephrine transport [inference]

norepinephrine secretion

catecholamine secretion [inference]

export from cell [inference]

secretion by cell [inference]

protein secretion [inference]

renin secretion into blood stream

signal release [inference]

catecholamine secretion [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

renin secretion into blood stream

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

renin secretion into blood stream

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

renin secretion into blood stream

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

renin secretion into blood stream

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

renin secretion into blood stream

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of catecholamine metabolic process [inference]

negative regulation of dopamine metabolic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of amine metabolic process [inference]

negative regulation of catecholamine metabolic process [inference]

negative regulation of dopamine metabolic process

positive regulation of metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

positive regulation of sulfur metabolic process [inference]

positive regulation of sulfur amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of sulfur amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

positive regulation of amine metabolic process [inference]

positive regulation of amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

positive regulation of small molecule metabolic process [inference]

positive regulation of sulfur amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

positive regulation of amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

regulation of cellular metabolic process [inference]

regulation of cellular ketone metabolic process [inference]

regulation of cellular amino acid metabolic process [inference]

positive regulation of amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

regulation of homocysteine metabolic process [inference]

positive regulation of homocysteine metabolic process

negative regulation of cellular metabolic process [inference]

negative regulation of catecholamine metabolic process [inference]

negative regulation of dopamine metabolic process

positive regulation of cellular metabolic process [inference]

positive regulation of amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

positive regulation of sulfur metabolic process [inference]

positive regulation of sulfur amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

regulation of catecholamine metabolic process [inference]

regulation of dopamine metabolic process [inference]

negative regulation of dopamine metabolic process

negative regulation of catecholamine metabolic process [inference]

negative regulation of dopamine metabolic process

regulation of sulfur metabolic process [inference]

regulation of sulfur amino acid metabolic process [inference]

positive regulation of sulfur amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

regulation of homocysteine metabolic process [inference]

positive regulation of homocysteine metabolic process

positive regulation of sulfur metabolic process [inference]

positive regulation of sulfur amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

regulation of nitrogen compound metabolic process [inference]

regulation of sulfur amino acid metabolic process [inference]

positive regulation of sulfur amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

regulation of homocysteine metabolic process [inference]

positive regulation of homocysteine metabolic process

regulation of amine metabolic process [inference]

regulation of cellular amino acid metabolic process [inference]

positive regulation of amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

regulation of homocysteine metabolic process [inference]

positive regulation of homocysteine metabolic process

negative regulation of amine metabolic process [inference]

negative regulation of catecholamine metabolic process [inference]

negative regulation of dopamine metabolic process

positive regulation of amine metabolic process [inference]

positive regulation of amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

regulation of catecholamine metabolic process [inference]

regulation of dopamine metabolic process [inference]

negative regulation of dopamine metabolic process

negative regulation of catecholamine metabolic process [inference]

negative regulation of dopamine metabolic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of amine metabolic process [inference]

negative regulation of catecholamine metabolic process [inference]

negative regulation of dopamine metabolic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of sulfur amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

positive regulation of amine metabolic process [inference]

positive regulation of amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

regulation of small molecule metabolic process [inference]

regulation of cellular ketone metabolic process [inference]

regulation of cellular amino acid metabolic process [inference]

positive regulation of amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

regulation of homocysteine metabolic process [inference]

positive regulation of homocysteine metabolic process

regulation of sulfur amino acid metabolic process [inference]

positive regulation of sulfur amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

regulation of homocysteine metabolic process [inference]

positive regulation of homocysteine metabolic process

positive regulation of small molecule metabolic process [inference]

positive regulation of sulfur amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

positive regulation of amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

regulation of primary metabolic process [inference]

regulation of cellular amino acid metabolic process [inference]

positive regulation of amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

regulation of homocysteine metabolic process [inference]

positive regulation of homocysteine metabolic process

regulation of catecholamine metabolic process [inference]

regulation of dopamine metabolic process [inference]

negative regulation of dopamine metabolic process

negative regulation of catecholamine metabolic process [inference]

negative regulation of dopamine metabolic process

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

synaptic transmission, dopaminergic

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

positive regulation of secretion [inference]

positive regulation of lactation

regulation of lactation [inference]

positive regulation of lactation

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of lactation

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

positive regulation of sulfur metabolic process [inference]

positive regulation of sulfur amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of sulfur amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

positive regulation of amine metabolic process [inference]

positive regulation of amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

positive regulation of small molecule metabolic process [inference]

positive regulation of sulfur amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

positive regulation of amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

positive regulation of sulfur metabolic process [inference]

positive regulation of sulfur amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of lactation

positive regulation of developmental process [inference]

positive regulation of lactation

positive regulation of multicellular organismal process [inference]

positive regulation of lactation

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of catecholamine metabolic process [inference]

negative regulation of dopamine metabolic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of amine metabolic process [inference]

negative regulation of catecholamine metabolic process [inference]

negative regulation of dopamine metabolic process

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of smooth muscle cell proliferation

negative regulation of cellular metabolic process [inference]

negative regulation of catecholamine metabolic process [inference]

negative regulation of dopamine metabolic process

regulation of developmental process [inference]

positive regulation of developmental process [inference]

positive regulation of lactation

regulation of multicellular organismal development [inference]

regulation of lactation [inference]

positive regulation of lactation

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of cellular ketone metabolic process [inference]

regulation of cellular amino acid metabolic process [inference]

positive regulation of amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

regulation of homocysteine metabolic process [inference]

positive regulation of homocysteine metabolic process

negative regulation of cellular metabolic process [inference]

negative regulation of catecholamine metabolic process [inference]

negative regulation of dopamine metabolic process

positive regulation of cellular metabolic process [inference]

positive regulation of amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

positive regulation of sulfur metabolic process [inference]

positive regulation of sulfur amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

regulation of catecholamine metabolic process [inference]

regulation of dopamine metabolic process [inference]

negative regulation of dopamine metabolic process

negative regulation of catecholamine metabolic process [inference]

negative regulation of dopamine metabolic process

regulation of sulfur metabolic process [inference]

regulation of sulfur amino acid metabolic process [inference]

positive regulation of sulfur amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

regulation of homocysteine metabolic process [inference]

positive regulation of homocysteine metabolic process

positive regulation of sulfur metabolic process [inference]

positive regulation of sulfur amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation [inference]

negative regulation of smooth muscle cell proliferation

regulation of smooth muscle cell proliferation [inference]

negative regulation of smooth muscle cell proliferation

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

positive regulation of sulfur metabolic process [inference]

positive regulation of sulfur amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of smooth muscle cell proliferation

negative regulation of cellular metabolic process [inference]

negative regulation of catecholamine metabolic process [inference]

negative regulation of dopamine metabolic process

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of lactation

regulation of multicellular organismal development [inference]

regulation of lactation [inference]

positive regulation of lactation

regulation of biological quality [inference]

regulation of blood pressure

regulation of hormone levels [inference]

hormone metabolic process [inference]

estrogen metabolic process

regulation of body fluid levels [inference]

regulation of lactation [inference]

positive regulation of lactation

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
extracellular space	ISO
cytosol	ISO
plasma membrane	IEA
membrane	IBA
axon	IDA	21846718

GO Hierarchy

cellular component

cellular anatomical entity [inference]

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

postsynaptic membrane

cell junction [inference]

synapse [inference]

glutamatergic synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

neuron spine [inference]

dendritic spine

glial cell projection

organelle [inference]

membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle

cell body

dendritic spine

Displaying **all 5** entries
GO Term	Evidence Code	PMID
magnesium ion binding	IEA
catechol O-methyltransferase activity	ISO
catechol O-methyltransferase activity	IDA	12584150
catechol O-methyltransferase activity	IBA
catechol O-methyltransferase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring one-carbon groups [inference]

methyltransferase activity [inference]

O-methyltransferase activity [inference]

catechol O-methyltransferase activity

S-adenosylmethionine-dependent methyltransferase activity [inference]

catechol O-methyltransferase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

magnesium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

catechol O-methyltransferase

Functional Category

H: Coenzyme transport and metabolism
I: Lipid transport and metabolism
K: Transcription

Displaying entries **1 - 10** of 11 in total

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Gene Ontology
L-dopa O-methyltransferase activity
O-methyltransferase activity
catechol O-methyltransferase activity
catecholamine catabolic process
catecholamine metabolic process
dopamine metabolic process
magnesium ion binding
metal ion binding
methylation
orcinol O-methyltransferase activity

Displaying **all 3** entries
InterPro
Catechol O-methyltransferase, eukaryotic
Class I-like SAM-dependent O-methyltransferase
S-adenosyl-L-methionine-dependent methyltransferase superfamily

Alliance of Genome Resources

Expression

Displaying **all 5** entries
Location	References
axon	PMID:21846718
dendrite	PMID:21846718
postsynaptic membrane	PMID:7617303
dendritic spine	PMID:7617303
cell body	PMID:21846718

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0080855	Parkinsonism	Alliance of Genome Resources
DOID:10763	hypertension	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 71 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	1312	Xenbase:XB-GENE-5865481	HUMAN59230
Mus musculus	12846	Xenbase:XB-GENE-948947	MOUSE19552
Xenopus tropicalis	24267	Xenbase:XB-GENE-948947
Canis lupus familiaris	445450		CANLF10595
Pan troglodytes	458655		PANTR25982
Danio rerio	561372	Xenbase:XB-GENE-5865481	DANRE42593
Danio rerio	565370	ZFIN:ZDB-GENE-040724-164	DANRE01869
Macaca mulatta	712548		MACMU00872
Sus scrofa	100155530		PIGXX07450
Taeniopygia guttata	100223814		TAEGU05974

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Last updated: April 7, 2025