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catechol-O-methyltransferase

Summary

Gene Symbol

Comt

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

24267

PubChem

24267

Alliance of Genome Resources

RGD:2379

Annotation

Keyword

3D-structure
Alternative initiation
Catecholamine metabolism
Cell membrane
Cytoplasm
Lipid metabolism
Magnesium
Metal-binding
Methyltransferase
Neurotransmitter degradation
Phosphoprotein
Proteomics identification
Reference proteome
S-adenosyl-L-methionine
Signal-anchor
Transmembrane helix

Proteins

Displaying **all 4** entries
UniProt	Protein Name
A0A8I6A1I0
P22734
F2W8B1
F2W8B0

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 68 in total

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GO Term	Evidence Code	PMID
behavioral fear response	ISO
dopamine metabolic process	IBA IEA ISO
response to organic cyclic compound	IEP	15964593
multicellular organismal response to stress	ISO
dopamine catabolic process	ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

S-adenosylhomocysteine metabolic process

cellular modified amino acid metabolic process [inference]

S-adenosylhomocysteine metabolic process

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

amine metabolic process [inference]

biogenic amine metabolic process [inference]

catecholamine metabolic process

norepinephrine metabolic process

dopamine metabolic process

dopamine catabolic process

catecholamine catabolic process

dopamine catabolic process

amine catabolic process [inference]

cellular biogenic amine catabolic process [inference]

catecholamine catabolic process

dopamine catabolic process

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

protein alkylation [inference]

protein methylation

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

organonitrogen compound catabolic process [inference]

amine catabolic process [inference]

cellular biogenic amine catabolic process [inference]

catecholamine catabolic process

dopamine catabolic process

catabolic process [inference]

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process

dopamine catabolic process

organic substance catabolic process [inference]

organic cyclic compound catabolic process [inference]

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process

dopamine catabolic process

organonitrogen compound catabolic process [inference]

amine catabolic process [inference]

cellular biogenic amine catabolic process [inference]

catecholamine catabolic process

dopamine catabolic process

organic hydroxy compound catabolic process [inference]

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process

dopamine catabolic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

methylation

macromolecule methylation [inference]

protein methylation

hormone metabolic process [inference]

estrogen metabolic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

S-adenosylhomocysteine metabolic process

icosanoid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

unsaturated fatty acid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

energy reserve metabolic process [inference]

glycogen metabolic process

cellular modified amino acid metabolic process [inference]

S-adenosylhomocysteine metabolic process

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

phenol-containing compound metabolic process [inference]

catechol-containing compound metabolic process [inference]

catecholamine metabolic process

norepinephrine metabolic process

dopamine metabolic process

dopamine catabolic process

catecholamine catabolic process

dopamine catabolic process

catechol-containing compound catabolic process [inference]

catecholamine catabolic process

dopamine catabolic process

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process

dopamine catabolic process

aromatic compound catabolic process [inference]

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process

dopamine catabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

sulfur compound metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process

dopamine catabolic process

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

unsaturated fatty acid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

polysaccharide metabolic process [inference]

glucan metabolic process [inference]

glycogen metabolic process

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

S-adenosylhomocysteine metabolic process

lipid metabolic process [inference]

steroid metabolic process [inference]

estrogen metabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

unsaturated fatty acid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

protein alkylation [inference]

protein methylation

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

S-adenosylhomocysteine metabolic process

icosanoid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

unsaturated fatty acid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

polysaccharide metabolic process [inference]

glucan metabolic process [inference]

glycogen metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

S-adenosylhomocysteine metabolic process

icosanoid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

unsaturated fatty acid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

lipid metabolic process [inference]

steroid metabolic process [inference]

estrogen metabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

unsaturated fatty acid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

macromolecule metabolic process [inference]

polysaccharide metabolic process [inference]

glucan metabolic process [inference]

glycogen metabolic process

macromolecule biosynthetic process [inference]

gene expression

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

protein alkylation [inference]

protein methylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation

protein alkylation [inference]

protein methylation

macromolecule methylation [inference]

protein methylation

S-adenosylmethionine metabolic process

carbohydrate derivative metabolic process [inference]

glycosyl compound metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

steroid metabolic process [inference]

estrogen metabolic process

phenol-containing compound metabolic process [inference]

catechol-containing compound metabolic process [inference]

catecholamine metabolic process

norepinephrine metabolic process

dopamine metabolic process

dopamine catabolic process

catecholamine catabolic process

dopamine catabolic process

catechol-containing compound catabolic process [inference]

catecholamine catabolic process

dopamine catabolic process

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process

dopamine catabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

organic cyclic compound catabolic process [inference]

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process

dopamine catabolic process

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

S-adenosylhomocysteine metabolic process

cellular modified amino acid metabolic process [inference]

S-adenosylhomocysteine metabolic process

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

amine metabolic process [inference]

biogenic amine metabolic process [inference]

catecholamine metabolic process

norepinephrine metabolic process

dopamine metabolic process

dopamine catabolic process

catecholamine catabolic process

dopamine catabolic process

amine catabolic process [inference]

cellular biogenic amine catabolic process [inference]

catecholamine catabolic process

dopamine catabolic process

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

protein alkylation [inference]

protein methylation

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

organonitrogen compound catabolic process [inference]

amine catabolic process [inference]

cellular biogenic amine catabolic process [inference]

catecholamine catabolic process

dopamine catabolic process

organic substance catabolic process [inference]

organic cyclic compound catabolic process [inference]

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process

dopamine catabolic process

organonitrogen compound catabolic process [inference]

amine catabolic process [inference]

cellular biogenic amine catabolic process [inference]

catecholamine catabolic process

dopamine catabolic process

organic hydroxy compound catabolic process [inference]

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process

dopamine catabolic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic hydroxy compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

catechol-containing compound metabolic process [inference]

catecholamine metabolic process

norepinephrine metabolic process

dopamine metabolic process

dopamine catabolic process

catecholamine catabolic process

dopamine catabolic process

catechol-containing compound catabolic process [inference]

catecholamine catabolic process

dopamine catabolic process

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process

dopamine catabolic process

organic hydroxy compound catabolic process [inference]

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process

dopamine catabolic process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

synaptic transmission, dopaminergic

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to phosphate starvation

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

S-adenosylhomocysteine metabolic process

icosanoid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

unsaturated fatty acid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

energy reserve metabolic process [inference]

glycogen metabolic process

cellular modified amino acid metabolic process [inference]

S-adenosylhomocysteine metabolic process

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

phenol-containing compound metabolic process [inference]

catechol-containing compound metabolic process [inference]

catecholamine metabolic process

norepinephrine metabolic process

dopamine metabolic process

dopamine catabolic process

catecholamine catabolic process

dopamine catabolic process

catechol-containing compound catabolic process [inference]

catecholamine catabolic process

dopamine catabolic process

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process

dopamine catabolic process

aromatic compound catabolic process [inference]

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process

dopamine catabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

sulfur compound metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process

dopamine catabolic process

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

unsaturated fatty acid metabolic process [inference]

prostanoid metabolic process [inference]

prostaglandin metabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

renin secretion into blood stream

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

renin secretion into blood stream

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

renin secretion into blood stream

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to phosphate starvation

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to phosphate starvation

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to cocaine

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to cocaine

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to cocaine

cellular response to oxygen-containing compound [inference]

cellular response to cocaine

cellular response to salt [inference]

cellular response to cocaine

export from cell [inference]

secretion by cell [inference]

protein secretion [inference]

renin secretion into blood stream

signal release [inference]

catecholamine secretion [inference]

reproductive process [inference]

multi-organism reproductive process [inference]

female pregnancy

multicellular organismal process [inference]

system process [inference]

renal system process [inference]

renal absorption [inference]

renal protein absorption [inference]

renal albumin absorption

renal filtration

renal tubular secretion [inference]

renal sodium excretion

excretion [inference]

renal tubular secretion [inference]

renal sodium excretion

digestive system process [inference]

mastication

nervous system process [inference]

cognition

learning or memory

learning

associative learning [inference]

visual learning

nonassociative learning [inference]

habituation

memory

short-term memory

neuromuscular process [inference]

startle response

behavior [inference]

behavioral defense response [inference]

behavioral fear response

learning or memory

learning

associative learning [inference]

visual learning

nonassociative learning [inference]

habituation

memory

short-term memory

visual behavior [inference]

visual learning

exploration behavior

multicellular organismal response to stress

fear response

behavioral fear response

response to pain

multicellular organism growth

multi-multicellular organism process [inference]

female pregnancy

developmental process

anatomical structure morphogenesis [inference]

cerebellar cortex morphogenesis

anatomical structure development [inference]

blood vessel development [inference]

artery development

glomerulus development

animal organ development [inference]

kidney development

growth [inference]

developmental growth [inference]

multicellular organism growth

response to stimulus [inference]

response to stress

response to hypoxia

defense response [inference]

behavioral defense response [inference]

behavioral fear response

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to phosphate starvation

multicellular organismal response to stress

fear response

behavioral fear response

response to pain

response to starvation [inference]

cellular response to starvation [inference]

cellular response to phosphate starvation

response to external stimulus [inference]

startle response

detection of external stimulus [inference]

detection of temperature stimulus [inference]

detection of temperature stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in sensory perception of pain

response to extracellular stimulus [inference]

response to nutrient levels [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to phosphate starvation

response to food

response to starvation [inference]

cellular response to starvation [inference]

cellular response to phosphate starvation

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to phosphate starvation

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

cellular response to external stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to phosphate starvation

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to abiotic stimulus [inference]

response to temperature stimulus

detection of temperature stimulus [inference]

detection of temperature stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in sensory perception of pain

response to radiation [inference]

response to light stimulus [inference]

visual behavior [inference]

visual learning

detection of abiotic stimulus [inference]

detection of temperature stimulus [inference]

detection of temperature stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in sensory perception of pain

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

response to endogenous stimulus [inference]

response to hormone [inference]

response to peptide hormone [inference]

response to angiotensin

response to estrogen

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid [inference]

response to corticosterone

response to mineralocorticoid [inference]

response to corticosterone

cellular response to endogenous stimulus [inference]

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to cocaine

response to chemical [inference]

response to organic substance [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to hormone [inference]

response to peptide hormone [inference]

response to angiotensin

response to estrogen

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid [inference]

response to corticosterone

response to mineralocorticoid [inference]

response to corticosterone

response to organonitrogen compound [inference]

response to amine [inference]

response to amphetamine

response to alkaloid [inference]

response to cocaine [inference]

cellular response to cocaine

cellular response to alkaloid [inference]

cellular response to cocaine

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to cocaine

response to monoamine [inference]

response to catecholamine [inference]

response to dopamine

response to peptide [inference]

response to peptide hormone [inference]

response to angiotensin

response to organic cyclic compound

response to cocaine [inference]

cellular response to cocaine

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid [inference]

response to corticosterone

response to mineralocorticoid [inference]

response to corticosterone

cellular response to organic cyclic compound [inference]

cellular response to cocaine

response to catecholamine [inference]

response to dopamine

response to lipid [inference]

response to lipopolysaccharide

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid [inference]

response to corticosterone

response to mineralocorticoid [inference]

response to corticosterone

response to cytokine

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to cocaine

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to cocaine

response to alcohol [inference]

response to corticosterone

response to ketone [inference]

response to corticosterone

response to food

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to cocaine

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to cocaine

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to cocaine

cellular response to oxygen-containing compound [inference]

cellular response to cocaine

cellular response to salt [inference]

cellular response to cocaine

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to amine [inference]

response to amphetamine

response to alkaloid [inference]

response to cocaine [inference]

cellular response to cocaine

cellular response to alkaloid [inference]

cellular response to cocaine

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to cocaine

response to monoamine [inference]

response to catecholamine [inference]

response to dopamine

response to peptide [inference]

response to peptide hormone [inference]

response to angiotensin

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to cocaine

response to oxygen-containing compound [inference]

response to lipopolysaccharide

response to cocaine [inference]

cellular response to cocaine

response to catecholamine [inference]

response to dopamine

response to alcohol [inference]

response to corticosterone

response to peptide [inference]

response to peptide hormone [inference]

response to angiotensin

response to ketone [inference]

response to corticosterone

cellular response to oxygen-containing compound [inference]

cellular response to cocaine

response to salt

response to cocaine [inference]

cellular response to cocaine

cellular response to salt [inference]

cellular response to cocaine

detection of stimulus [inference]

detection of external stimulus [inference]

detection of temperature stimulus [inference]

detection of temperature stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in sensory perception of pain

detection of abiotic stimulus [inference]

detection of temperature stimulus [inference]

detection of temperature stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in sensory perception of pain

detection of stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in sensory perception of pain

detection of stimulus involved in sensory perception of pain [inference]

detection of temperature stimulus involved in sensory perception of pain

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to phosphate starvation

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to phosphate starvation

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to cocaine

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to cocaine

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to cocaine

cellular response to oxygen-containing compound [inference]

cellular response to cocaine

cellular response to salt [inference]

cellular response to cocaine

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

renin secretion into blood stream

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

renin secretion into blood stream

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

renin secretion into blood stream

establishment of localization [inference]

transport [inference]

secretion [inference]

secretion by cell [inference]

protein secretion [inference]

renin secretion into blood stream

signal release [inference]

catecholamine secretion [inference]

organic substance transport [inference]

lipid transport [inference]

sterol transport [inference]

cholesterol transport [inference]

cholesterol efflux

protein transport [inference]

protein secretion [inference]

renin secretion into blood stream

organic cation transport [inference]

norepinephrine transport [inference]

norepinephrine secretion

monoamine transport [inference]

catecholamine transport [inference]

dopamine transport [inference]

dopamine secretion

norepinephrine transport [inference]

norepinephrine secretion

catecholamine secretion [inference]

organic hydroxy compound transport [inference]

sterol transport [inference]

cholesterol transport [inference]

cholesterol efflux

catecholamine transport [inference]

dopamine transport [inference]

dopamine secretion

norepinephrine transport [inference]

norepinephrine secretion

catecholamine secretion [inference]

nitrogen compound transport [inference]

protein transport [inference]

protein secretion [inference]

renin secretion into blood stream

monoamine transport [inference]

catecholamine transport [inference]

dopamine transport [inference]

dopamine secretion

norepinephrine transport [inference]

norepinephrine secretion

catecholamine secretion [inference]

export from cell [inference]

secretion by cell [inference]

protein secretion [inference]

renin secretion into blood stream

signal release [inference]

catecholamine secretion [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

renin secretion into blood stream

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

renin secretion into blood stream

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

renin secretion into blood stream

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

renin secretion into blood stream

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

renin secretion into blood stream

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of catecholamine metabolic process [inference]

negative regulation of dopamine metabolic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of amine metabolic process [inference]

negative regulation of catecholamine metabolic process [inference]

negative regulation of dopamine metabolic process

positive regulation of metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

positive regulation of sulfur metabolic process [inference]

positive regulation of sulfur amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of sulfur amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

positive regulation of amine metabolic process [inference]

positive regulation of amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

positive regulation of small molecule metabolic process [inference]

positive regulation of sulfur amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

positive regulation of amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

regulation of cellular metabolic process [inference]

regulation of cellular ketone metabolic process [inference]

regulation of cellular amino acid metabolic process [inference]

positive regulation of amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

regulation of homocysteine metabolic process [inference]

positive regulation of homocysteine metabolic process

negative regulation of cellular metabolic process [inference]

negative regulation of catecholamine metabolic process [inference]

negative regulation of dopamine metabolic process

positive regulation of cellular metabolic process [inference]

positive regulation of amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

positive regulation of sulfur metabolic process [inference]

positive regulation of sulfur amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

regulation of catecholamine metabolic process [inference]

regulation of dopamine metabolic process [inference]

negative regulation of dopamine metabolic process

negative regulation of catecholamine metabolic process [inference]

negative regulation of dopamine metabolic process

regulation of sulfur metabolic process [inference]

regulation of sulfur amino acid metabolic process [inference]

positive regulation of sulfur amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

regulation of homocysteine metabolic process [inference]

positive regulation of homocysteine metabolic process

positive regulation of sulfur metabolic process [inference]

positive regulation of sulfur amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

regulation of nitrogen compound metabolic process [inference]

regulation of sulfur amino acid metabolic process [inference]

positive regulation of sulfur amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

regulation of homocysteine metabolic process [inference]

positive regulation of homocysteine metabolic process

regulation of amine metabolic process [inference]

regulation of cellular amino acid metabolic process [inference]

positive regulation of amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

regulation of homocysteine metabolic process [inference]

positive regulation of homocysteine metabolic process

negative regulation of amine metabolic process [inference]

negative regulation of catecholamine metabolic process [inference]

negative regulation of dopamine metabolic process

positive regulation of amine metabolic process [inference]

positive regulation of amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

regulation of catecholamine metabolic process [inference]

regulation of dopamine metabolic process [inference]

negative regulation of dopamine metabolic process

negative regulation of catecholamine metabolic process [inference]

negative regulation of dopamine metabolic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of amine metabolic process [inference]

negative regulation of catecholamine metabolic process [inference]

negative regulation of dopamine metabolic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of sulfur amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

positive regulation of amine metabolic process [inference]

positive regulation of amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

regulation of small molecule metabolic process [inference]

regulation of cellular ketone metabolic process [inference]

regulation of cellular amino acid metabolic process [inference]

positive regulation of amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

regulation of homocysteine metabolic process [inference]

positive regulation of homocysteine metabolic process

regulation of sulfur amino acid metabolic process [inference]

positive regulation of sulfur amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

regulation of homocysteine metabolic process [inference]

positive regulation of homocysteine metabolic process

positive regulation of small molecule metabolic process [inference]

positive regulation of sulfur amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

positive regulation of amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

regulation of primary metabolic process [inference]

regulation of cellular amino acid metabolic process [inference]

positive regulation of amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

regulation of homocysteine metabolic process [inference]

positive regulation of homocysteine metabolic process

regulation of catecholamine metabolic process [inference]

regulation of dopamine metabolic process [inference]

negative regulation of dopamine metabolic process

negative regulation of catecholamine metabolic process [inference]

negative regulation of dopamine metabolic process

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

synaptic transmission, dopaminergic

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

positive regulation of secretion [inference]

positive regulation of lactation

regulation of lactation [inference]

positive regulation of lactation

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of lactation

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

positive regulation of sulfur metabolic process [inference]

positive regulation of sulfur amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of sulfur amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

positive regulation of amine metabolic process [inference]

positive regulation of amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

positive regulation of small molecule metabolic process [inference]

positive regulation of sulfur amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

positive regulation of amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

positive regulation of sulfur metabolic process [inference]

positive regulation of sulfur amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of lactation

positive regulation of developmental process [inference]

positive regulation of lactation

positive regulation of multicellular organismal process [inference]

positive regulation of lactation

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of catecholamine metabolic process [inference]

negative regulation of dopamine metabolic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of amine metabolic process [inference]

negative regulation of catecholamine metabolic process [inference]

negative regulation of dopamine metabolic process

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of smooth muscle cell proliferation

negative regulation of cellular metabolic process [inference]

negative regulation of catecholamine metabolic process [inference]

negative regulation of dopamine metabolic process

regulation of developmental process [inference]

positive regulation of developmental process [inference]

positive regulation of lactation

regulation of multicellular organismal development [inference]

regulation of lactation [inference]

positive regulation of lactation

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of cellular ketone metabolic process [inference]

regulation of cellular amino acid metabolic process [inference]

positive regulation of amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

regulation of homocysteine metabolic process [inference]

positive regulation of homocysteine metabolic process

negative regulation of cellular metabolic process [inference]

negative regulation of catecholamine metabolic process [inference]

negative regulation of dopamine metabolic process

positive regulation of cellular metabolic process [inference]

positive regulation of amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

positive regulation of sulfur metabolic process [inference]

positive regulation of sulfur amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

regulation of catecholamine metabolic process [inference]

regulation of dopamine metabolic process [inference]

negative regulation of dopamine metabolic process

negative regulation of catecholamine metabolic process [inference]

negative regulation of dopamine metabolic process

regulation of sulfur metabolic process [inference]

regulation of sulfur amino acid metabolic process [inference]

positive regulation of sulfur amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

regulation of homocysteine metabolic process [inference]

positive regulation of homocysteine metabolic process

positive regulation of sulfur metabolic process [inference]

positive regulation of sulfur amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation [inference]

negative regulation of smooth muscle cell proliferation

regulation of smooth muscle cell proliferation [inference]

negative regulation of smooth muscle cell proliferation

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

positive regulation of sulfur metabolic process [inference]

positive regulation of sulfur amino acid metabolic process [inference]

positive regulation of homocysteine metabolic process

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of smooth muscle cell proliferation

negative regulation of cellular metabolic process [inference]

negative regulation of catecholamine metabolic process [inference]

negative regulation of dopamine metabolic process

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of lactation

regulation of multicellular organismal development [inference]

regulation of lactation [inference]

positive regulation of lactation

regulation of biological quality [inference]

regulation of blood pressure

regulation of hormone levels [inference]

hormone metabolic process [inference]

estrogen metabolic process

regulation of body fluid levels [inference]

regulation of lactation [inference]

positive regulation of lactation

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
membrane	IBA
postsynaptic membrane	IDA	7617303
postsynapse	IDA	7617303
intracellular membrane-bounded organelle	IEA ISO
plasma membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

postsynaptic membrane

cell junction [inference]

synapse [inference]

glutamatergic synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

neuron spine [inference]

dendritic spine

glial cell projection

organelle [inference]

membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle

cell body

postsynapse

dendritic spine

Displaying **all 2** entries
GO Term	Evidence Code	PMID
catechol O-methyltransferase activity	IBA IDA IEA ISO	12584150
magnesium ion binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring one-carbon groups [inference]

methyltransferase activity [inference]

O-methyltransferase activity [inference]

catechol O-methyltransferase activity

S-adenosylmethionine-dependent methyltransferase activity [inference]

catechol O-methyltransferase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

magnesium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

catechol O-methyltransferase

Functional Category

H: Coenzyme transport and metabolism
I: Lipid transport and metabolism
K: Transcription

Displaying entries **1 - 10** of 11 in total

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Gene Ontology
L-dopa O-methyltransferase activity
O-methyltransferase activity
catechol O-methyltransferase activity
catecholamine catabolic process
catecholamine metabolic process
dopamine metabolic process
magnesium ion binding
metal ion binding
methylation
orcinol O-methyltransferase activity

Displaying **all 3** entries
InterPro
Catechol O-methyltransferase, eukaryotic
Class I-like SAM-dependent O-methyltransferase
S-adenosyl-L-methionine-dependent methyltransferase superfamily

Alliance of Genome Resources

Expression

Displaying **all 5** entries
Location	References
cell body	PMID:21846718
dendritic spine	PMID:7617303
postsynaptic membrane	PMID:7617303
axon	PMID:21846718
dendrite	PMID:21846718

Disease

Disease Ontology

Displaying entries **1 - 10** of 40 in total

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DO ID	Disease Name	Source
DOID:0050741	alcohol dependence	Alliance of Genome Resources
DOID:0050742	nicotine dependence	Alliance of Genome Resources
DOID:0060001	withdrawal disorder	Alliance of Genome Resources
DOID:0060041	autism spectrum disorder	Alliance of Genome Resources
DOID:0080855	Parkinsonism	Alliance of Genome Resources
DOID:10283	prostate cancer	Alliance of Genome Resources
DOID:10591	pre-eclampsia	Alliance of Genome Resources
DOID:10763	hypertension	Alliance of Genome Resources
DOID:10933	obsessive-compulsive disorder	Alliance of Genome Resources
DOID:1094	attention deficit hyperactivity disorder	Alliance of Genome Resources

Ortholog

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	1312		HGNC:2228	HUMAN59230
Mus musculus	12846	10090_1:0049e4	MGI:88470	MOUSE19552
Canis lupus familiaris	445450			CANLF10595
Pan troglodytes	458655			PANTR25982
Xenopus tropicalis	549111		Xenbase:XB-GENE-948947
Xenopus tropicalis	549911		Xenbase:XB-GENE-5865481
Danio rerio	561372		ZFIN:ZDB-GENE-050913-117	DANRE42593
Danio rerio	565370		ZFIN:ZDB-GENE-040724-164	DANRE01869
Macaca mulatta	712548			MACMU00872
Sus scrofa	100155530			PIGXX07450

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements