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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
serpin family E member 1
Summary
- Gene Symbol
-
- Serpine1
- Organism
- Rattus norvegicus (Norway rat)
Annotation
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| positive regulation of fibroblast proliferation | ||
| cellular response to cGMP | ||
| mast cell activation | ||
| cellular response to mechanical stimulus | ||
| cellular response to fibroblast growth factor stimulus |
GO Hierarchy
- cellular response to nicotine
- cellular response to xenobiotic stimulus
- cellular response to nicotine
- cellular response to xenobiotic stimulus
- cellular response to nicotine
- cellular response to xenobiotic stimulus
biological process
cellular process [inference]
cellular response to stimulus [inference]
cellular response to chemical stimulus [inference]
cellular response to organic substance [inference]
cellular response to oxygen-containing compound [inference]
response to stimulus [inference]
response to endogenous stimulus [inference]
response to chemical [inference]
response to organic substance [inference]
response to hormone [inference]
response to organonitrogen compound [inference]
response to organic cyclic compound [inference]
response to lipid [inference]
cellular response to organic substance [inference]
cellular response to chemical stimulus [inference]
cellular response to organic substance [inference]
cellular response to oxygen-containing compound [inference]
response to nitrogen compound [inference]
response to oxygen-containing compound [inference]
cellular response to stimulus [inference]
cellular response to chemical stimulus [inference]
cellular response to organic substance [inference]
cellular response to oxygen-containing compound [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of signaling [inference]
regulation of locomotion [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of cell adhesion [inference]
regulation of cellular metabolic process [inference]
regulation of programmed cell death [inference]
positive regulation of cellular process [inference]
negative regulation of cellular process [inference]
regulation of cell motility [inference]
regulation of multicellular organismal process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| chromaffin granule | ||
| collagen-containing extracellular matrix | ||
| peptidase inhibitor complex | ||
| extracellular region | ||
| extracellular space |
| GO Term | Evidence Code | PMID |
|---|---|---|
| signaling receptor binding | ||
| serine-type endopeptidase inhibitor activity | ||
| protease binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Rodentia
- Group Name
- plasminogen activator inhibitor 1
- Functional Category
-
- O: Posttranslational modification, protein turnover, chaperones
- Q: Secondary metabolites biosynthesis, transport and catabolism
- T: Signal transduction mechanisms
- V: Defense mechanisms
| Gene Ontology |
|---|
| negative regulation of plasminogen activation |
| negative regulation of vascular wound healing |
| serine-type endopeptidase inhibitor activity |
| InterPro |
|---|
| Serpin domain |
| Serpin family |
| Serpin superfamily, domain 1 |
| Serpin superfamily, domain 2 |
| Serpin superfamily |
| Serpin, conserved site |
Alliance of Genome Resources
- Expression
| Location | References |
|---|---|
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050830 | peripheral artery disease | |
| DOID:0050831 | familial encephalopathy with neuroserpin inclusion bodies | |
| DOID:0050847 | sleep apnea | |
| DOID:0050848 | obstructive sleep apnea | |
| DOID:0050851 | glomerulosclerosis | |
| DOID:0050855 | renal fibrosis | |
| DOID:0050866 | oral squamous cell carcinoma | |
| DOID:0060181 | ischemic colitis | |
| DOID:0060903 | thrombosis | |
| DOID:0080208 | metabolic dysfunction-associated steatotic liver disease |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 5054 | HGNC:8583 | HUMAN90443 | ||
| 18787 | 10090_1:00193c | MGI:97608 | MOUSE47286 | |
| 34339 | FB:FBgn0032178 | |||
| 35519 | FB:FBgn0263109 | |||
| 35639 | FB:FBgn0044011 | |||
| 36931 | FB:FBgn0034195 | |||
| 45040 | FB:FBgn0024293 | |||
| 45908 | FB:FBgn0002930 | |||
| 178586 | WB:WBGene00005643 | |||
| 396945 | PIGXX20401 |
