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hydroxysteroid 11-beta dehydrogenase 1

Summary

Gene Symbol

Hsd11b1

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

25116

PubChem

25116

Alliance of Genome Resources

RGD:2834

Annotation

Keyword

Alternative promoter usage
Direct protein sequencing
Endoplasmic reticulum
Glycoprotein
NADP
Oxidoreductase
Reference proteome
Signal
Signal-anchor
Steroid metabolism
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P16232	7-oxosteroid reductase Corticosteroid 11-beta-dehydrogenase isozyme 1
A6JH26	7-oxosteroid reductase Corticosteroid 11-beta-dehydrogenase isozyme 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
regulation of pentose-phosphate shunt	IDA	16234247
lung development	ISO
response to nutrient levels	IEP	16941667
glucocorticoid catabolic process	IDA	12460758
steroid catabolic process	IBA

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

organic substance catabolic process [inference]

lipid catabolic process [inference]

steroid catabolic process

glucocorticoid catabolic process

organic cyclic compound catabolic process [inference]

steroid catabolic process

glucocorticoid catabolic process

biosynthetic process [inference]

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

glucocorticoid biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

glucocorticoid biosynthetic process

hormone metabolic process [inference]

mineralocorticoid metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

glucocorticoid biosynthetic process

steroid catabolic process

glucocorticoid catabolic process

glucocorticoid metabolic process [inference]

mineralocorticoid metabolic process

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

glucocorticoid biosynthetic process

lipid catabolic process [inference]

steroid catabolic process

glucocorticoid catabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

glucocorticoid biosynthetic process

steroid catabolic process

glucocorticoid catabolic process

glucocorticoid metabolic process [inference]

mineralocorticoid metabolic process

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

glucocorticoid biosynthetic process

lipid catabolic process [inference]

steroid catabolic process

glucocorticoid catabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

glucocorticoid biosynthetic process

steroid catabolic process

glucocorticoid catabolic process

glucocorticoid metabolic process [inference]

mineralocorticoid metabolic process

organic cyclic compound catabolic process [inference]

steroid catabolic process

glucocorticoid catabolic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

glucocorticoid biosynthetic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

steroid catabolic process

glucocorticoid catabolic process

organic cyclic compound catabolic process [inference]

steroid catabolic process

glucocorticoid catabolic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

glucocorticoid biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

glucocorticoid biosynthetic process

cellular process [inference]

mineralocorticoid metabolic process

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to estradiol stimulus

cellular response to organic cyclic compound [inference]

cellular response to estradiol stimulus

cellular response to oxygen-containing compound [inference]

cellular response to estradiol stimulus

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

lung development

response to stimulus [inference]

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels

response to chemical [inference]

response to organic substance [inference]

response to organic cyclic compound [inference]

response to estradiol [inference]

cellular response to estradiol stimulus

cellular response to organic cyclic compound [inference]

cellular response to estradiol stimulus

response to lipid [inference]

response to estradiol [inference]

cellular response to estradiol stimulus

cellular response to lipid [inference]

cellular response to estradiol stimulus

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to estradiol stimulus

cellular response to organic cyclic compound [inference]

cellular response to estradiol stimulus

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to estradiol stimulus

cellular response to organic cyclic compound [inference]

cellular response to estradiol stimulus

cellular response to oxygen-containing compound [inference]

cellular response to estradiol stimulus

response to oxygen-containing compound [inference]

response to estradiol [inference]

cellular response to estradiol stimulus

cellular response to oxygen-containing compound [inference]

cellular response to estradiol stimulus

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to estradiol stimulus

cellular response to organic cyclic compound [inference]

cellular response to estradiol stimulus

cellular response to oxygen-containing compound [inference]

cellular response to estradiol stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of catabolic process [inference]

regulation of carbohydrate catabolic process [inference]

regulation of pentose-phosphate shunt

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of purine nucleotide metabolic process [inference]

regulation of NADP metabolic process [inference]

regulation of pentose-phosphate shunt

regulation of generation of precursor metabolites and energy [inference]

regulation of pentose-phosphate shunt

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of purine nucleotide metabolic process [inference]

regulation of NADP metabolic process [inference]

regulation of pentose-phosphate shunt

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of purine nucleotide metabolic process [inference]

regulation of NADP metabolic process [inference]

regulation of pentose-phosphate shunt

regulation of amide metabolic process [inference]

regulation of pentose-phosphate shunt

regulation of small molecule metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of purine nucleotide metabolic process [inference]

regulation of NADP metabolic process [inference]

regulation of pentose-phosphate shunt

regulation of primary metabolic process [inference]

regulation of carbohydrate metabolic process [inference]

regulation of carbohydrate catabolic process [inference]

regulation of pentose-phosphate shunt

regulation of nucleobase-containing compound metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of purine nucleotide metabolic process [inference]

regulation of NADP metabolic process [inference]

regulation of pentose-phosphate shunt

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of purine nucleotide metabolic process [inference]

regulation of NADP metabolic process [inference]

regulation of pentose-phosphate shunt

regulation of generation of precursor metabolites and energy [inference]

regulation of pentose-phosphate shunt

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of purine nucleotide metabolic process [inference]

regulation of NADP metabolic process [inference]

regulation of pentose-phosphate shunt

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

mineralocorticoid metabolic process

Displaying **all 4** entries
GO Term	Evidence Code	PMID
nuclear membrane	IDA	11250946
endoplasmic reticulum membrane	IBA IEA ISO
intracellular membrane-bounded organelle	IBA
apical part of cell	IDA	12810566

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

intracellular organelle [inference]

intracellular membrane-bounded organelle

apical part of cell

Displaying entries **6 - 7** of 7 in total

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GO Term	Evidence Code	PMID
cortisol dehydrogenase activity
protein homodimerization activity	ISO

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

steroid dehydrogenase activity [inference]

steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity [inference]

11-beta-hydroxysteroid dehydrogenase (NADP+) activity

7-beta-hydroxysteroid dehydrogenase (NADP+) activity

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity [inference]

11-beta-hydroxysteroid dehydrogenase (NADP+) activity

7-beta-hydroxysteroid dehydrogenase (NADP+) activity

cortisol dehydrogenase activity

binding [inference]

protein binding [inference]

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

lipid binding [inference]

steroid binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NADP binding

organic cyclic compound binding [inference]

steroid binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NADP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

corticosteroid 11-beta-dehydrogenase isozyme 1

Functional Category

I: Lipid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 4** entries
Gene Ontology
11-beta-hydroxysteroid dehydrogenase (NADP+) activity
oxidoreductase activity
steroid binding
steroid catabolic process

Displaying **all 3** entries
InterPro
NAD(P)-binding domain superfamily
Short-chain dehydrogenase/reductase SDR
Short-chain dehydrogenase/reductase, conserved site

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
apical part of cell	PMID:12810566
nuclear membrane	PMID:11250946

Disease

Disease Ontology

Displaying **all 10** entries
DO ID	Disease Name	Source
DOID:0090139	cortisone reductase deficiency	Alliance of Genome Resources
DOID:0090140	cortisone reductase deficiency 2	Alliance of Genome Resources
DOID:10591	pre-eclampsia	Alliance of Genome Resources
DOID:10763	hypertension	Alliance of Genome Resources
DOID:10825	essential hypertension	Alliance of Genome Resources
DOID:1168	familial hyperlipidemia	Alliance of Genome Resources
DOID:1824	status epilepticus	Alliance of Genome Resources
DOID:3393	coronary artery disease	Alliance of Genome Resources
DOID:9352	type 2 diabetes mellitus	Alliance of Genome Resources
DOID:9970	obesity	Alliance of Genome Resources

Ortholog

Displaying entries **91 - 100** of **108** in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Balaenoptera musculus	118902100		BALMU24589
Arvicola amphibius	119827826	1047088_0:00459c
Microtus oregoni	121435825	111838_0:004b41
Dipodomys spectabilis	122109584	105255_0:001719
Panthera leo	122212187		PANLE31034
Ursus americanus	123785812		URSAM11468
Marmota monax	124097664	9995_0:001941
Sciurus carolinensis	124962037	30640_0:003be4
Perognathus longimembris pacificus	125359897	214514_0:00291b
Myodes glareolus	125403778	447135_0:001723

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Annotation

OrthoDB (Group)

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Acknowledgements