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alpha-L-fucosidase 1

Summary

Gene Symbol

FUCA1

Aliases

a-L-fucosidase 1
tissue fucosidase
α-L-fucosidase 1

Organism

Homo sapiens (human)

External Links

NCBI Gene

2517

HGNC

4006

KEGG Gene ID

hsa:2517

PubChem

2517

Alliance of Genome Resources

HGNC:4006

Annotation

Keyword

3D-structure
Disease variant
Glycoprotein
Glycosidase
Lipid metabolism
Lysosome
Phosphoprotein
Reference proteome
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
P04066	Alpha-L-fucosidase I Alpha-L-fucoside fucohydrolase 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
glycosaminoglycan catabolic process	NAS	11698403
glycoside catabolic process	IBA IDA	19666478
glycolipid catabolic process	ISS
fucose metabolic process	IBA IDA	19666478

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process

catabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

glycolipid catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

glycolipid catabolic process

carbohydrate derivative catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process

glycolipid catabolic process

glycosyl compound catabolic process [inference]

glycoside catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process

cellular metabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

glycolipid catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

glycolipid catabolic process

membrane lipid catabolic process [inference]

glycolipid catabolic process

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

glycolipid catabolic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fucose metabolic process

lipid metabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

glycolipid catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

glycolipid catabolic process

membrane lipid catabolic process [inference]

glycolipid catabolic process

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

glycolipid catabolic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycolipid catabolic process

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fucose metabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fucose metabolic process

lipid metabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

glycolipid catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

glycolipid catabolic process

membrane lipid catabolic process [inference]

glycolipid catabolic process

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

glycolipid catabolic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycolipid catabolic process

macromolecule metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan catabolic process

macromolecule catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process

carbohydrate derivative metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan catabolic process

carbohydrate derivative catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process

glycolipid catabolic process

glycosyl compound catabolic process [inference]

glycoside catabolic process

glycosyl compound metabolic process [inference]

glycoside metabolic process [inference]

glycoside catabolic process

glycosyl compound catabolic process [inference]

glycoside catabolic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycolipid catabolic process

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

glycolipid catabolic process

carbohydrate derivative catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process

glycolipid catabolic process

glycosyl compound catabolic process [inference]

glycoside catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

glycolipid catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

glycolipid catabolic process

membrane lipid catabolic process [inference]

glycolipid catabolic process

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

glycolipid catabolic process

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
intracellular membrane-bounded organelle	IDA
extracellular region	TAS
cytoplasm	TAS	4074382
lysosomal lumen	TAS
extracellular exosome	HDA	19056867 23533145

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

azurophil granule lumen

intracellular organelle lumen [inference]

vacuolar lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

azurophil granule lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle

vacuole [inference]

lytic vacuole [inference]

lysosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle

vacuole [inference]

lytic vacuole [inference]

lysosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 2** entries
GO Term	Evidence Code	PMID
alpha-L-fucosidase activity	IBA IDA TAS	11698403 19666478
protein binding	IPI	32296183

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing O-glycosyl compounds [inference]

fucosidase activity [inference]

alpha-L-fucosidase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000179163

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K01206

Name

alpha-L-fucosidase [EC:3.2.1.51]

References

Rhea

RHEA:12288

H₂O + an α-L-fucoside

L-fucose + an alcohol

Enzyme

3.2.1.51

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of 77 in total

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DO ID	Disease Name	Source
DOID:0040099	livedoid vasculitis	DisGeNET
DOID:0050328	congenital hypothyroidism	DisGeNET
DOID:0050461	aspartylglucosaminuria	DisGeNET
DOID:0050865	tongue squamous cell carcinoma	DisGeNET
DOID:0060249	scoliosis	DisGeNET
DOID:0060823	syndromic X-linked intellectual disability 94	DisGeNET
DOID:0080199	colorectal carcinoma	DisGeNET
DOID:0080522	thyroid gland anaplastic carcinoma	DisGeNET
DOID:0111135	congenital generalized lipodystrophy type 1	DisGeNET
DOID:0111136	congenital generalized lipodystrophy type 2	DisGeNET

The Human Phenotype Ontology

Displaying entries **1 - 10** of 82 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000158	Macroglossia
HP:0000164	Abnormality of the dentition
HP:0000179	Thick lower lip vermilion
HP:0000240	Abnormality of skull size
HP:0000248	Brachycephaly
HP:0000280	Coarse facial features
HP:0000316	Hypertelorism
HP:0000365	Hearing impairment
HP:0000369	Low-set ears

Displaying **all 2** entries
Disease ID	Disease Name
OMIM:230000	fucosidosis
ORPHA:349	fucosidosis

PubChem Disease

GHR Health Conditions

Fucosidosis

MedGen Diseases

Fucosidosis

OMIM Phenotypes

FUCOSIDOSIS

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

Displaying entries **1 - 10** of 75 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	189173	WB:WBGene00012225
Drosophila melanogaster	3772574	FB:FBgn0285958
Danio rerio	335494	ZFIN:ZDB-GENE-030131-7434	DANRE15363
Danio rerio	445165	ZFIN:ZDB-GENE-040801-78	DANRE15233
Astyanax mexicanus	103023687		ASTMX00855
Ictalurus punctatus	108257267		ICTPU19290
Electrophorus electricus	113575085		ELEEL15211
Esox lucius	105009640		ESOLU27552
Salmo salar	106570718		SALSA74826
Salmo trutta	115187227		SALTR52044

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

International Collaboration

Acknowledgements