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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Tissue alpha-L-fucosidase
Summary
- UniProt ID
- P04066
- Gene Symbol
-
- FUCA1
- Organism
- Homo sapiens (human)
External Links
- GlycoProtDB
- GPDB0011351
- GlyConnect
- GlyGen
- P04066
- PubChem
- P04066
- SwissLipids
- The Human Metabolome Database
- HMDBP00875
- The O-GlcNAc Database
- P04066
- O-GlcNAcAtlas
- P04066
Annotation
- Keyword
-
- 3D-structure
- Disease variant
- Glycoprotein
- Glycosidase
- Lipid metabolism
- Lysosome
- Phosphoprotein
- Reference proteome
- Signal
- Gene Ontology (GO)
| GO Term |
|---|
| fucose metabolic process |
| glycolipid catabolic process |
| glycoside catabolic process |
| glycosaminoglycan catabolic process |
| GO Term |
|---|
| azurophil granule lumen |
| lysosomal lumen |
| extracellular exosome |
| extracellular region |
| cytoplasm |
| lysosome |
| intracellular membrane-bounded organelle |
| GO Term |
|---|
| alpha-L-fucosidase activity |
Sequence
MRAPGMRSRPAGPALLLLLLFLGAAESVRRAQPPRRYTPDWPSLDSRPLPAWFDEAKFGVFIHWGVFSVPAWGSEWFWWHWQGEGRPQYQRFMRDNYPPGFSYADFGPQFTARFFHPEEWADLFQAAGAKYVVLTTKHHEGFTNWPSPVSWNWNSKDVGPHRDLVGELGTALRKRNIRYGLYHSLLEWFHPLYLLDKKNGFKTQHFVSAKTMPELYDLVNSYKPDLIWSDGEWECPDTYWNSTNFLSWLYNDSPVKDEVVVNDRWGQNCSCHHGGYYNCEDKFKPQSLPDHKWEMCTSIDKFSWGYRRDMALSDVTEESEIISELVQTVSLGGNYLLNIGPTKDGLIVPIFQERLLAVGKWLSINGEAIYASKPWRVQWEKNTTSVWYTSKGSAVYAIFLHWPENGVLNLESPITTSTTKITMLGIQGDLKWSTDPDKGLFISLPQLPPSAVPAEFAWTIKLTGVK
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 241 | N-linked (GlcNAc...) asparagine |
|
||
| 268 | N-linked (GlcNAc...) asparagine |
|
||
| 270 |
|
|||
| 382 | N-linked (GlcNAc...) asparagine | |||
| 383 |
|
G75418YA
G77669RF
G28622IK
G40206WX
G04854VP
G94470IW
G92135MA
G34989PA
G45395BF
G20706XG
G14972EH
G43223CG
G58954YZ
G61256FT
G76295SF
G15664MX
G45495MK
G84452RH
G10488MI
G07755XJ
G35253PZ
G72747WU
G01485JJ
G73968GN
G90659AW
G77547TA
G64409MC
G47644PP
G05049YU
G31852PQ
G90575OW
G23719VF
G11314AS
G41247ZX
G50282JC
G02815KT
G74724QE
G92275SC
G49108TO
G82443XX
G36666WX
G70375MX
G78790NZ
G70441OD
G96091TT
G01650EU
G80920RR
G62765YT
G39188ZX
G06110VR
G84349RE
G92050GC
G28681TP
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Neutrophil degranulation | Homo sapiens |
| Reactions specific to the complex N-glycan synthesis pathway | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0040099 | livedoid vasculitis | |
| DOID:0050328 | congenital hypothyroidism | |
| DOID:0050461 | aspartylglucosaminuria | |
| DOID:0050865 | tongue squamous cell carcinoma | |
| DOID:0060249 | scoliosis | |
| DOID:0060823 | syndromic X-linked intellectual disability 94 | |
| DOID:0080199 | colorectal carcinoma | |
| DOID:0080522 | thyroid gland anaplastic carcinoma | |
| DOID:0111135 | congenital generalized lipodystrophy type 1 | |
| DOID:0111136 | congenital generalized lipodystrophy type 2 |
