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proprotein convertase subtilisin/kexin type 1

Summary

Gene Symbol

Pcsk1

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

25204

PubChem

25204

Alliance of Genome Resources

RGD:3272

Annotation

Keyword

Calcium
Cleavage on pair of basic residues
Cytoplasmic vesicle
Disulfide bond
Glycoprotein
Reference proteome
Serine protease
Signal
Zymogen

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P28840	Prohormone convertase 1 Proprotein convertase 1
A6I4E7	Prohormone convertase 1 Proprotein convertase 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 27 in total

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GO Term	Evidence Code	PMID
response to xenobiotic stimulus	IEP	10971617
response to glucose	IEP	17283238
response to chlorate	IEP	17221210
response to organic cyclic compound
protein processing	ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process

amide metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing

insulin processing

peptide biosynthetic process

amide biosynthetic process [inference]

peptide biosynthetic process

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing

insulin processing

peptide biosynthetic process

protein metabolic process [inference]

proteolysis [inference]

protein processing

protein autoprocessing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

insulin processing

protein maturation [inference]

protein processing

protein autoprocessing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

insulin processing

insulin metabolic process [inference]

insulin processing

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process

organic substance biosynthetic process [inference]

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process

hormone metabolic process [inference]

peptide hormone processing

insulin processing

cellular metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

protein autoprocessing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

insulin processing

protein maturation [inference]

protein processing

protein autoprocessing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

insulin processing

insulin metabolic process [inference]

insulin processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

protein autoprocessing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

insulin processing

protein maturation [inference]

protein processing

protein autoprocessing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

insulin processing

insulin metabolic process [inference]

insulin processing

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing

insulin processing

peptide biosynthetic process

protein metabolic process [inference]

proteolysis [inference]

protein processing

protein autoprocessing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

insulin processing

protein maturation [inference]

protein processing

protein autoprocessing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

insulin processing

insulin metabolic process [inference]

insulin processing

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process

organic substance biosynthetic process [inference]

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process

cellular developmental process [inference]

cell differentiation [inference]

neurogenesis

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

pancreas development

gland development [inference]

pituitary gland development

cellular developmental process [inference]

cell differentiation [inference]

neurogenesis

response to stimulus [inference]

response to stress [inference]

response to wounding [inference]

response to axon injury

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to endogenous stimulus [inference]

response to hormone [inference]

response to peptide hormone

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to chemical [inference]

response to xenobiotic stimulus

response to organic substance [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to hormone [inference]

response to peptide hormone

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to carbohydrate [inference]

response to monosaccharide [inference]

response to hexose [inference]

response to glucose

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone

response to organic cyclic compound

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to forskolin

response to lipid [inference]

response to lipopolysaccharide

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to cytokine [inference]

response to interleukin-1

response to calcium ion

response to alcohol [inference]

response to forskolin

response to ketone [inference]

response to forskolin

response to inorganic substance [inference]

response to metal ion [inference]

response to calcium ion

response to chlorate

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone

response to oxygen-containing compound [inference]

response to carbohydrate [inference]

response to monosaccharide [inference]

response to hexose [inference]

response to glucose

response to alcohol [inference]

response to forskolin

response to peptide [inference]

response to peptide hormone

response to ketone [inference]

response to forskolin

response to salt [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

regulation of secretion by cell [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion

regulation of protein transport [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion

regulation of secretion by cell [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

peptide hormone processing

insulin processing

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
extracellular space	ISO
extracellular space	IDA	9389490
extracellular space	IBA
trans-Golgi network	IDA	10906712
membrane	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen

intracellular organelle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

trans-Golgi network

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

dendrite

perikaryon

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle

secretory vesicle [inference]

secretory granule

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle

secretory vesicle [inference]

secretory granule

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle

secretory vesicle [inference]

secretory granule

cell body [inference]

neuronal cell body

neuron projection terminus [inference]

axon terminus

perinuclear region of cytoplasm

presynapse [inference]

axon terminus

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
endopeptidase activity	ISO
endopeptidase activity	IDA	10087454
endopeptidase activity	IMP	9556596
serine-type endopeptidase activity	ISO
serine-type endopeptidase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity [inference]

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

binding [inference]

protein binding [inference]

identical protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Proprotein convertase subtilisin/kexin type

Functional Category

E: Amino acid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
hydrolase activity
peptide hormone processing
proteolysis
serine-type endopeptidase activity
serine-type peptidase activity

Displaying **all 8** entries
InterPro
Galactose-binding-like domain superfamily
Kexin/furin catalytic domain
P domain
Peptidase S8, subtilisin, His-active site
Peptidase S8, subtilisin, Ser-active site
Peptidase S8, subtilisin-related
Peptidase S8/S53 domain superfamily
Peptidase S8/S53 domain

Alliance of Genome Resources

Expression

Displaying **all 8** entries
Location	References
axon terminus	PMID:10906712
perikaryon	PMID:17543468
dendrite	PMID:10906712
neuronal cell body	PMID:10906712 PMID:17543468
extracellular space	PMID:9389490
trans-Golgi network	PMID:10906712
secretory granule	PMID:10806118
perinuclear region of cytoplasm	PMID:9389490

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:4195	hyperglycemia	Alliance of Genome Resources
DOID:9352	type 2 diabetes mellitus	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **104** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Saccharomyces cerevisiae S288C	5045	SGD:S000005182
Saccharomyces cerevisiae S288C	5046	SGD:S000005182
Homo sapiens	5122	Xenbase:XB-GENE-983314	HUMAN80102
Saccharomyces cerevisiae S288C	5125	SGD:S000005182
Saccharomyces cerevisiae S288C	9159	SGD:S000005182
Mus musculus	18548	Xenbase:XB-GENE-983314	MOUSE10990
Saccharomyces cerevisiae S288C	18550	SGD:S000005182
Saccharomyces cerevisiae S288C	18551	SGD:S000005182
Saccharomyces cerevisiae S288C	18552	SGD:S000005182
Saccharomyces cerevisiae S288C	18553	SGD:S000005182

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External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements