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fucosyltransferase 5

Summary

Gene Symbol

FUT5

Aliases

FUC-TV
alpha (1,3) fucosyltransferase

Organism

Homo sapiens (human)

External Links

NCBI Gene

2527

GGDB ID

gg005

HGNC

4016

mRNA

NM_002034

map

19p13.3

Protein

NP_002025

OMIM

136835

KEGG Gene ID

hsa:2527

PubChem

2527

Alliance of Genome Resources

HGNC:4016

Annotation

Keyword

Glycoprotein
Glycosyltransferase
Golgi apparatus
Lipid metabolism
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q11128	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT5 Fucosyltransferase 5 Fucosyltransferase V Galactoside 3-L-fucosyltransferase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
oligosaccharide biosynthetic process	TAS
protein N-linked glycosylation	IDA	29593094
protein O-linked glycosylation	IDA	29593094
carbohydrate metabolic process	TAS	1339443
oligosaccharide metabolic process	IDA	1740457 9737988

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

ceramide metabolic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

catabolic process [inference]

small molecule catabolic process [inference]

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fucose catabolic process [inference]

L-fucose catabolic process

organic substance catabolic process [inference]

carbohydrate catabolic process [inference]

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fucose catabolic process [inference]

L-fucose catabolic process

biosynthetic process [inference]

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

cellular metabolic process [inference]

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process

primary metabolic process [inference]

carbohydrate metabolic process

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fucose metabolic process [inference]

fucose catabolic process [inference]

L-fucose catabolic process

L-fucose metabolic process [inference]

L-fucose catabolic process

hexose catabolic process [inference]

fucose catabolic process [inference]

L-fucose catabolic process

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fucose catabolic process [inference]

L-fucose catabolic process

oligosaccharide metabolic process

oligosaccharide biosynthetic process

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

carbohydrate catabolic process [inference]

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fucose catabolic process [inference]

L-fucose catabolic process

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fucose metabolic process [inference]

fucose catabolic process [inference]

L-fucose catabolic process

L-fucose metabolic process [inference]

L-fucose catabolic process

hexose catabolic process [inference]

fucose catabolic process [inference]

L-fucose catabolic process

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fucose catabolic process [inference]

L-fucose catabolic process

small molecule catabolic process [inference]

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fucose catabolic process [inference]

L-fucose catabolic process

glycosylation [inference]

fucosylation

macromolecule glycosylation [inference]

protein glycosylation

organic substance metabolic process [inference]

carbohydrate metabolic process

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fucose metabolic process [inference]

fucose catabolic process [inference]

L-fucose catabolic process

L-fucose metabolic process [inference]

L-fucose catabolic process

hexose catabolic process [inference]

fucose catabolic process [inference]

L-fucose catabolic process

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fucose catabolic process [inference]

L-fucose catabolic process

oligosaccharide metabolic process

oligosaccharide biosynthetic process

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

carbohydrate catabolic process [inference]

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fucose catabolic process [inference]

L-fucose catabolic process

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation

macromolecule glycosylation [inference]

protein glycosylation

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

organic substance catabolic process [inference]

carbohydrate catabolic process [inference]

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fucose catabolic process [inference]

L-fucose catabolic process

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process

Displaying **all 3** entries
GO Term	Evidence Code	PMID
Golgi apparatus	TAS	11698403
Golgi cisterna membrane	IEA
Golgi membrane	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

Golgi cisterna membrane

bounding membrane of organelle [inference]

Golgi membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

Displaying **all 4** entries
GO Term	Evidence Code	PMID
3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity	IDA	14718375 1740457 9737988
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity	IDA	14718375 1740457 17604274 29593094 7721776 9737988
alpha-(1->3)-fucosyltransferase activity	IBA TAS	11698403
fucosyltransferase activity	IDA	17604274 7721776

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

hexosyltransferase activity [inference]

fucosyltransferase activity

3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity

alpha-(1->3)-fucosyltransferase activity

4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity

Gene Ontology information from NCBI Gene and UniProt.

GlycoGene Database (GGDB)

GGDB ID

gg005

Gene Symbol

FUT5

Reactions

Displaying **all 7** entries
Donor	Acceptor	Product	Reference
GDP-Fuc	G32061UE	G20009FG	17604274
GDP-Fuc	G61459JW	G00052MO	16484342
GDP-Fuc	G46055MA		10622713
GDP-Fuc	G84224TW	G57548NB	8780523
GDP-Fuc	G00056MO	G39023AU	8780523
GDP-Fuc	G00065MO	G00054MO	8780523
GDP-Fuc	G00055MO	G00051MO	8780523

Displaying **all 9** entries
Donor	Acceptor	Product	Reference
GDP-Fuc	G84224TW	G57548NB	8780523
GDP-Fuc	G32061UE	G20009FG	17604274
GDP-Fuc	G40696TO	G00048MO	9079712
GDP-Fuc	G03499BP	G08176ZW	9079712
GDP-Fuc	G00056MO	G39023AU	8780523
GDP-Fuc	G46055MA		10622713
GDP-Fuc	G61459JW	G00052MO	16484342 9079712
GDP-Fuc	G00055MO	G00051MO	8780523
GDP-Fuc	G00065MO	G00054MO	8780523

KEGG BRITE Database

Orthology

K07633

Name

galactoside alpha-1,3-fucosyltransferase 5 [EC:2.4.1.65]

References

1740457

Reactions

Displaying entries **1 - 10** of 11 in total

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KEGG Reaction	Enzyme	Acceptor	Product
R06230	2.4.1.- 2.4.1.152 2.4.1.65	G84034JH	G65223RT
R06227	2.4.1.- 2.4.1.152 2.4.1.65	G07075ZE	G03564IA
R06075	2.4.1.- 2.4.1.65	G01767JJ	G96401FK
R06038	2.4.1.- 2.4.1.152 2.4.1.65	G84034JH	G76439VL
R06039	2.4.1.- 2.4.1.152 2.4.1.65	G77285LE	G00851XQ
R06025	2.4.1.- 2.4.1.152 2.4.1.65	G58896AZ	G72002FC
R06224	2.4.1.- 2.4.1.152 2.4.1.65	G52160KJ	G20180GO
R06222	2.4.1.- 2.4.1.152 2.4.1.65	G00851XQ	G52160KJ
R06221	2.4.1.- 2.4.1.152 2.4.1.65	G76439VL	G91560NT
R06095	2.4.1.- 2.4.1.152 2.4.1.65	G13636IT	G89659QV

Rhea

RHEA:14257

a β-D-galactosyl-(1→4)-N-acetyl-β-D-glucosaminyl derivative + GDP-β-L-fucose

a β-D-galactosyl-(1→4)-[α-L-fucosyl-(1→3)]-N-acetyl-β-D-glucosaminyl derivative + H⁺ + GDP

Enzyme

2.4.1.152

PMID

RHEA:23628

a β-D-galactosyl-(1→3)-N-acetyl-β-D-glucosaminyl derivative + GDP-β-L-fucose

a β-D-galactosyl-(1→3)-[α-L-fucosyl-(1→4)]-N-acetyl-β-D-glucosaminyl derivative + H⁺ + GDP

Enzyme

2.4.1.65

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of 15 in total

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DO ID	Disease Name	Source
DOID:0080199	colorectal carcinoma	DisGeNET
DOID:10283	prostate cancer	DisGeNET
DOID:10286	prostate carcinoma	DisGeNET
DOID:10534	stomach cancer	DisGeNET DisGeNET
DOID:1324	lung cancer	DisGeNET
DOID:1325	bronchus cancer	DisGeNET
DOID:1508	candidiasis	Alliance of Genome Resources
DOID:3571	liver cancer	DisGeNET
DOID:3683	lung benign neoplasm	DisGeNET
DOID:3904	bronchus carcinoma	DisGeNET

Ortholog

Displaying entries **11 - 20** of 30 in total

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Species	Gene ID	Orthologous MAtrix
Meleagris gallopavo	100544367	MELGA09441
Gorilla gorilla gorilla	129523557	GORGO15073
Pongo abelii	100432841	PONAB16293
Pongo abelii	100433605	PONAB16293
Pongo abelii	112130139	PONAB16293
Canis lupus familiaris	449024	CANLF07980
Ailuropoda melanoleuca	100468460	AILME01120
Loxodonta africana	100662623	LOXAF02415
Loxodonta africana	100675894	LOXAF02415
Sus scrofa	100513844	PIGXX18729

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

GlycoGene Database (GGDB)

KEGG BRITE Database

International Collaboration

Acknowledgements