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5-hydroxytryptamine receptor 4

Summary

Gene Symbol

Htr4

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

25324

PubChem

25324

Alliance of Genome Resources

RGD:2850

Annotation

Keyword

Alternative splicing
Cell membrane
Disulfide bond
Endosome
G-protein coupled receptor
Glycoprotein
Palmitate
Reference proteome
Transmembrane helix

Proteins

Displaying **all 4** entries
UniProt	Protein Name
Q62758	Serotonin receptor 4
A0A9K3Y826	Serotonin receptor 4
C4WYH1	Serotonin receptor 4
C4WYH2	Serotonin receptor 4

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
mucus secretion	IEA ISO
regulation of appetite	IEA
large intestinal transit	IEA ISO
maintenance of gastrointestinal epithelium	IEA ISO
adenylate cyclase-activating serotonin receptor signaling pathway	IEA ISO ISS

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

gamma-aminobutyric acid signaling pathway

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

signal transduction [inference]

G protein-coupled receptor signaling pathway

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway

adenylate cyclase-activating serotonin receptor signaling pathway

G protein-coupled serotonin receptor signaling pathway

serotonin receptor signaling pathway [inference]

adenylate cyclase-activating serotonin receptor signaling pathway

multicellular organismal process [inference]

system process [inference]

digestive system process [inference]

maintenance of gastrointestinal epithelium

intestinal motility [inference]

large intestinal transit

nervous system process [inference]

cognition

secretion by tissue [inference]

mucus secretion

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

epithelial structure maintenance [inference]

maintenance of gastrointestinal epithelium

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

epithelial structure maintenance [inference]

maintenance of gastrointestinal epithelium

localization [inference]

establishment of localization [inference]

transport [inference]

secretion [inference]

body fluid secretion [inference]

mucus secretion

secretion by tissue [inference]

mucus secretion

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

gamma-aminobutyric acid signaling pathway

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway

adenylate cyclase-activating serotonin receptor signaling pathway

G protein-coupled serotonin receptor signaling pathway

serotonin receptor signaling pathway [inference]

adenylate cyclase-activating serotonin receptor signaling pathway

regulation of cellular component biogenesis [inference]

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

regulation of postsynapse assembly

regulation of cellular component organization [inference]

regulation of synapse organization [inference]

regulation of synapse assembly [inference]

regulation of postsynapse assembly

regulation of postsynapse organization [inference]

regulation of postsynapse assembly

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

regulation of postsynapse assembly

regulation of biological quality [inference]

regulation of appetite

regulation of body fluid levels [inference]

body fluid secretion [inference]

mucus secretion

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
membrane	ISO
postsynapse	IEA ISO
plasma membrane	IBA IEA ISO ISS
endosome	IEA
dendrite	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

bounding membrane of organelle [inference]

endosome membrane

cell junction [inference]

synapse

glutamatergic synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

postsynapse

Displaying **all 3** entries
GO Term	Evidence Code	PMID
serotonin receptor activity	IEA ISO
neurotransmitter receptor activity	IBA
G protein-coupled serotonin receptor activity	IBA IEA IMP ISO ISS	10220570 7796807

GO Hierarchy

molecular function

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

G protein-coupled amine receptor activity [inference]

G protein-coupled serotonin receptor activity

serotonin receptor activity

neurotransmitter receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

5-hydroxytryptamine receptor 4

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
G protein-coupled serotonin receptor signaling pathway
adenylate cyclase-activating adrenergic receptor signaling pathway
chemical synaptic transmission
regulation of appetite

Displaying **all 3** entries
InterPro
5-Hydroxytryptamine 4 receptor
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:8689	anorexia nervosa	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **113** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	3360		HGNC:5299	HUMAN81601
Mus musculus	15562	10090_1:005043	MGI:109246	MOUSE23451
Drosophila melanogaster	41549		FB:FBgn0038063
Drosophila melanogaster	42652		FB:FBgn0038980
Bos taurus	317708			BOVIN33709
Sus scrofa	397431			PIGXX20065
Pan troglodytes	462175			PANTR36513
Danio rerio	559089		ZFIN:ZDB-GENE-091204-249
Macaca mulatta	710046			MACMU39796
Drosophila melanogaster	3885573		FB:FBgn0250910

GlyTouCan

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UniCarb-DR

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements